Results 71 to 80 of about 10,795 (199)

First-pass metabolism of cyclosporin by the gut [PDF]

, 1991
Cyclosporin is thought to be exclusively metabolised in the liver. We instilled cyclosporin into the small bowel of 2 patients during the anhepatic phase of liver transplantation; cyclosporin metabolites were readily detected in portal venous blood.
Awni, W. M., Awni, Walid M., Kolars, Joseph C., Merion, Robert M., Watkins, Paul B., Watkins, Paul   +5 more
core   +1 more source

Australian clinical practice guideline: diagnosis and treatment of idiopathic multicentric Castleman disease

Internal Medicine Journal, EarlyView.
Abstract Idiopathic multicentric Castleman disease (iMCD) is a rare condition. The pathogenesis is incompletely understood; however, interleukin‐6 (IL‐6) is a major mediator. The clinical presentation is heterogeneous, from mild constitutional symptoms to severe multi‐organ failure.
Dipti Talaulikar, Jun Yen Ng, Adam Bryant, Annmarie Bosco, Hugh C. Caterson, Pratyush Giri, Pravin Hissaria, Simon J. Harrison, Stephen Lade, Connull Leslie, Jacinta Perram, H. Miles Prince, Dejan Radeski, Maureen Rischmueller, Craig Wallington‐Gates, Nicholas Weber, Alberta Hoi   +16 more
wiley   +1 more source

Effect of Terbinafine on the Pharmacokinetics of Cyclosporin in Humans

, 1994
Cyclosporin is largely metabolized by hepatic cytochrome P450 enzymes, and azole drugs that inhibit cytochrome P450 may precipitate cyclosporin toxicity. The allylamine terbinafine binds to a small subfraction of hepatic cytochrome P450 in type I fashion,
Kendall, Francis, Johnston, Atholl, Hill, Stephanie A, Thomas, Robert C, Finlay, Andrew Y, Smith, Stephen G, Long, C Colin   +6 more
core   +1 more source

Cortical blindness during cyclosporin treatment

, 1994
A 40-year-old man developed cortical blindness during cyclosporin treatment shortly after an allogeneic bone marrow transplantation for chronic myeloid leukaemia.
Vlasveld, L. T., Dellemijn, P. L.I., Joosse, M. V., Van Den Bent, M. J.; id_orcid, Cornelissen, J. J.   +4 more
core   +1 more source

Risk Factors and Management of Gingival Enlargement: A Systematic Review and Meta‐Analysis

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Objective To identify risk factors/indicators of gingival enlargement (GE) and to summarise evidence for its management. Methods A systematic review was undertaken following PRISMA guidelines and divided into PECOTS and PICOTS questions, related to risk factors/indicators and treatment studies, respectively.
Luigi Nibali, Emily Ming‐Chieh Lu, Helvis E. S. Paz, Jing Kang, Nagihan Bostanci, Georgios N. Belibasakis   +5 more
wiley   +1 more source

Reversible denaturation of cyclosporin synthetase by urea

, 1996
The reversible denaturation of the multifunctional polypeptide, cyclosporin synthetase, by urea was analyzed. It is possible to discriminate between at least two stages of enzyme denaturation.
Lawen, Alfons, Joachim Dittmann, Dittmann, Joachim, Kleinkauf, Horst, François Vaillant, Vaillant, François, Horst Kleinkauf, Alfons Lawen   +7 more
core   +1 more source

Management of Non‐Plaque‐Induced Gingival Conditions: A Systematic Review—Part 2: Inflammatory and Immune Conditions; Neoplasms; and Gingival Pigmentation

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Aims This systematic review assesses current evidence on the management of non‐plaque (dental biofilm)‐induced gingival diseases and conditions (NPIGDs), including (i) inflammatory and immune conditions, (ii) neoplasms and (iii) gingival pigmentations.
Maria Clotilde Carra, Cecile Wasielewski, Bruno Špiljak, Maja Sabalić‐Schoener, Sebastien Jungo, Ivan Alajbeg   +5 more
wiley   +1 more source

Successful cyclosporin and ustekinumab combination therapy in a patient with severe steroid-refractory ulcerative colitis

Therapeutic Advances in Gastroenterology, 2020
The therapeutic management of patients with severe steroid-refractory ulcerative colitis still represents a critical clinical challenge. In this setting, cyclosporin is an effective and rapidly acting induction treatment that is applied in combination ...
Ingo Ganzleben, Carol Geppert, Lourdes Osaba, Simon Hirschmann, Andreas Nägel, Christian Glück, Arthur Hoffman, Timo Rath, Daniel Nagore, Markus F. Neurath, Raja Atreya   +10 more
doaj   +1 more source

Systemic Therapy for Paediatric Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis: A Systematic Review of Current Evidence and Limitations

Journal of Paediatrics and Child Health, EarlyView.
ABSTRACT Aim The role of systemic therapy in paediatric Stevens–Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) remains undefined. Management is primarily guided by observational data and variable practice patterns. This systematic review aims to integrate recent evidence and evaluate clinical outcomes associated with systemic therapies in ...
Samantha Ting, Kangjie Reuel Chua, Li‐Chuen Wong, Gloria Fong   +3 more
wiley   +1 more source

Role of the cyclosporin-sensitive transcription factor NFAT1 in the allergic response

Memorias do Instituto Oswaldo Cruz, 1997
Proteins belonging to the NFAT (nuclear factor of activated T cells) family of transcription factors are expressed in most immune cell types, and play a central role in the transcription of cytokine genes, such as IL-2, IL-4, IL-5, IL-13, IFN-gamma, TNF ...
João PB Viola, Anjana Rao
doaj   +1 more source