Results 51 to 60 of about 10,795 (199)

Long-Term Efficacy and Safety of 0.1% Cyclosporine A Cationic Emulsion in Advanced Dry Eye Disease: A 24-Month Retrospective Study

Pharmaceuticals
Background: To evaluate the effectiveness of 0.1% cyclosporine A (CsA) cationic emulsion in managing advanced dry eye disease (DED), based on clinical parameters: Ocular Surface Disease Index (OSDI), best-corrected visual acuity (BCVA), Tear Break-Up ...
Monika Sarnat-Kucharczyk, Martyna Nowak, Ewa Mrukwa-Kominek   +2 more
doaj   +1 more source

Application of Size and Maturation Functions to Population Pharmacokinetic Modeling of Pediatric Patients

Pharmaceutics, 2019
Traditionally, dosage for pediatric patients has been optimized using simple weight-scaled methods, but these methods do not always meet the requirements of children.
Hyun-moon Back, Jong Bong Lee, Nayoung Han, Sungwoo Goo, Eben Jung, Junyeong Kim, Byungjeong Song, Sook Hee An, Jung Tae Kim, Sandy Jeong Rhie, Yoon Sun Ree, Jung-woo Chae, JaeWoo Kim, Hwi-yeol Yun   +13 more
doaj   +1 more source

Next Generation Hosts for Protein Recognition, Assembly and More

Chemistry – A European Journal, EarlyView.
The original design of synthetic receptors for proteins was based on macrocycles with a hydrophobic core and a polar/charged periphery. This design, geared towards protein recognition, facilitates receptor self‐assembly. Macrocycle oligomerization, in turn, contributes to protein assembly as evidenced in many cocrystal structures.
Peter B. Crowley
wiley   +1 more source

Pharmacokinetics of cyclosporin: a microemulsion in children with idiopathic nephrotic syndrome

Clinics, 2012
OBJECTIVE: We present a prospective study of a microemulsion of cyclosporin to treat idiopathic nephrotic syndrome in ten children with normal renal function who presented cyclosporin trough levels between 50 and 150 ng/ml and achieved complete remission
Luciana dos Santos Henriques, Fabíola de Marcos Matos, Maria Helena Vaisbich   +2 more
doaj   +1 more source

Case Report: Successful Treatment of Steroid-Refractory Immune Checkpoint Inhibitor-Related Pure Red Cell Aplasia With Cyclosporin

Frontiers in Oncology, 2020
Anemia associated with Immune checkpoint inhibitor (ICI) is usually hemolytic and regenerative. Cases of non-regenerative pure red cell aplasia are rare, and typically improve upon drug discontinuation and after corticotherapy. We herein report a case of
Alexandre Gérard, Serena Romani, Elise Van-Obberghen, Audrey Fresse, Marine Muzzone, Nadège Parassol, Annick Boscagli, Fanny Rocher, Delphine Borchiellini, Milou-Daniel Drici   +9 more
doaj   +1 more source

Metal‐dependent regulated cell death: Molecular architecture and translational frontiers

iMeta, EarlyView.
Intracellular metal dyshomeostasis orchestrates distinct regulated cell death programs, including iron‐driven ferroptosis, copper‐mediated cuproptosis, calcicoptosis, newly designated zincoptosis, mnoptosis, and coptosis. This review systematically delineates their molecular architectures—spanning from Sorafenib‐induced lipid peroxidation and ...
Haoliang Hu, Zhe Chen, Yaqi Li, Jiayi Peng, Jiangang Cao, Hong Zhou, Mengqi Wang, Yuejia Du, Hailin Wu, Huiqin Zhao, Shifang Huang, Dianmei Yu, Meiqing Liu, Olga V. Shevchenko, Natalia Yu. Matveeva, Yiyuan Yang, Kerui Huang, Deguan Lv, Junxia Min, Linxi Chen, Fudi Wang   +20 more
wiley   +1 more source

Gingival Hyperplasia Associated with Cyclosporine and Amlodipine Administration in a Child with Nephrotic Syndrome and Regression after Therapy Correction: Clinical Case

Вопросы современной педиатрии
Background. Gingival hyperplasia is a pathological diffuse or local outgrowth of fibrous tissue in the gums and paradontium. Excessive growth of gum tissue can cause periodontal inflammation and results in tooth loss, speech and chewing issues, aesthetic
Alina B. Strok, Maria N. Kostyleva, Anna V. Kostina   +2 more
doaj   +1 more source

Papular dermatitis: response to cyclosporin

, 2000
BACKGROUND/AIM: Papular dermatitis is a persistent pruritic papular dermatitis, often refractory to treatment. The objective was to examine the effectiveness of cyclosporin for the treatment of this condition.
Hendi, A, Kerdel, Fa, Alvarez, E, Elgart, G W   +3 more
core   +1 more source

Peptide‐based antibacterial nanoplatforms: Design principles, stimuli‐regulated behaviors, and applications

Responsive Materials, EarlyView.
Peptide‐based antibacterial nanoplatforms, encompassing self‐assembled peptides and peptide‐engineered inorganic, polymeric, and lipid nanocarriers, are systematically reviewed. The article highlights design principles and stimuli‐responsive regulation for improving peptide stability, delivery efficiency, and antibacterial performance.
Peng Tan, Chenlong Zhou, Shuaikang Yang, Zhenduo Chen, Guanghui Zhao, Qi Tang, Haoyu Yan, Feng Li, Xi Ma   +8 more
wiley   +1 more source

The effect of cyclosporin and lipopolysaccharide on fibroblasts: Implications for cyclosporin-induced gingival overgrowth

, 1992
Drug-induced gingival overgrowth is an adverse side effect associated principally with 3 different types of drugs; specifically the antiepileptic phenytoin, the calcium channel antagonist nifedipine, and the immunosuppressant cyclosporin.
Seymour G.J., Barber M.T., Savage N.W.
core   +1 more source