Results 31 to 40 of about 50,966 (210)

Intravital Multimodal Imaging of Human Cortical Organoid Transplantation in a Mouse Model of Chronic Stroke

Advanced Science, EarlyView.
A multimodal intravital imaging platform enables longitudinal tracking of human cortical organoids transplanted into chronic stroke lesions. By combining surgical microscopy, MRI, bioluminescence imaging, and two‐photon fluorescence microscopy, the platform captures graft placement, viability dynamics, and cellular‐scale morphology in vivo, offering a ...
Jinghui Wang, Guanda Qiao, Honglin Tan, Colleen Russel, Baixuan Yang, Mengyang Jacky Li, Kexin Wang, Jiadi Xu, Chengyan Chu, Miroslaw Janowski, Tian‐Ming Fu, Piotr Walczak, Yajie Liang   +12 more
wiley   +1 more source

What to do when traditional rescue therapies fail in acute severe ulcerative colitis [PDF]

Intestinal Research
Acute severe ulcerative colitis (ASUC) is a medical emergency that affects approximately 25% of patients with ulcerative colitis at some point in time in their lives. Outcomes of ASUC are highly variable.
Christopher F. D. Li Wai Suen, Matthew C. Choy, Peter De Cruz   +2 more
doaj   +1 more source

SEVERE FORM OF ATOPIC DERMATITIS AS A THERAPEUTIC CHALLENGE

Slovenska pediatrija, 2022
Atopic dermatitis (AD) is the most common chronic inflammatory skin disease of childhood. The disease is characterized by recurrent eczematoid itchy skin lesions caused by a combination of genetic predisposition and environmental factors (1-2).
Janja Golobič, Gašper Markelj
doaj   +1 more source

Engineering Immunoregenerative Therapy via an Immunomodulatory Binary Pharmacology Hydrogel Depot for Prolonged Allograft Survival

Advanced Science, EarlyView.
An immunomodulatory hydrogel (iGEL) forms spontaneously upon subcutaneous injection, acting as a tissue‐adhesive depot. It releases anti‐rejection and regenerative agents in response to inflammation, suppressing T‐cell activity, promoting vascular repair, and restoring allograft function without systemic immunosuppression.
Ning Wang, Ruiqi Sun, Yang Fu, Zhonghan Wu, Xinyu Tong, Hong Tang, Wentao Zhao, Zhi Liang, Jintao Zheng, Yanan Guan, Ke Zhou, Penghong Song, Shusen Zheng, Hangxiang Wang, Haiyang Xie   +14 more
wiley   +1 more source

Identification of a Nonribosomal Peptide Analog With Activity Against Multiple Gram‐Positive Bacteria via a Synthetic Bioinformatic Natural Product Discovery Approach

Advanced Science, EarlyView.
The genome of Rhodococcus erythropolis D‐1 was analyzed by bioinformatic tools to mine a novel nonribosomal peptide synthetase (NRPS) gene cluster. A nonribosomal peptide analog ZURJC5 associated with the NRPS was chemically synthesized. Through structure‐activity relationship studies, ZURJC28 was ultimately obtained and showed antibacterial activity ...
Keyi Chen, Jiayi Liang, Yujia Wu, Jianan Xu, Yi Liu, Wenguang Wang, Xinhang Jiang, Benjie Gao, Yueyue Wang, Hui Jiang   +9 more
wiley   +1 more source

Calcineurin‐Dependent Stress Adaptation Enables Caspofungin Heteroresistance Leading to Stable Resistance in Candida Glabrata

Advanced Science, EarlyView.
Caspofungin heteroresistance is prevalent in clinical Candida glabrata isolates and depends on calcineurin‐mediated stress adaptation. This transient phenotype serves as a reservoir for resistance evolution, enabling the emergence of stable resistant descendants under prolonged drug pressure.
Yanyu Su, Yi Li, Meng Xiao, Dan Guo, David S. Perlin, Erika Shor, Yingchun Xu, Yingxing Li   +7 more
wiley   +1 more source

Cyclosporin, Tacrolimus, Mycophenolic Acid, and Dexamethasone Suppress Peripheral Blood Mononuclear Cell Proliferation and Inhibit Interferon-Gamma, IL-10 and IL-13 Production In Vitro

Turkish Journal of Immunology
Objective: The primary goals of immunosuppressive therapy are to prevent graft rejection and to improve graft and patient survival. Long-term maintenance therapy after kidney transplantation includes cyclosporine A (CsA), tacrolimus (FK506), mycophenolic
Abdel-Rahman Youssef
doaj   +1 more source

Lethal and Sublethal Toxicity Assessment of Cyclosporin C (a Fungal Toxin) against Plutella xylostella (L.)

Toxins, 2022
Secondary metabolites/toxins produced by Purpeocillium lilacinum (Hypocreales; Phiocordycipitaceae), a well-known insect pathogen, can be used for the management of different insect pests.
Jianhui Wu, Xiaochen Zhang, Muhammad Hamid Bashir, Shaukat Ali   +3 more
doaj   +1 more source

Therapies for Chronic Spontaneous Urticaria: Present and Future Developments

Pharmaceuticals
Chronic spontaneous urticaria (CSU) is a complex dermatological condition characterized by recurrent wheals and/or angioedema lasting for more than six weeks, significantly impairing patients’ quality of life.
Riccardo Asero, Paolo Calzari, Silvia Vaienti, Massimo Cugno   +3 more
doaj   +1 more source

Application of Size and Maturation Functions to Population Pharmacokinetic Modeling of Pediatric Patients

Pharmaceutics, 2019
Traditionally, dosage for pediatric patients has been optimized using simple weight-scaled methods, but these methods do not always meet the requirements of children.
Hyun-moon Back, Jong Bong Lee, Nayoung Han, Sungwoo Goo, Eben Jung, Junyeong Kim, Byungjeong Song, Sook Hee An, Jung Tae Kim, Sandy Jeong Rhie, Yoon Sun Ree, Jung-woo Chae, JaeWoo Kim, Hwi-yeol Yun   +13 more
doaj   +1 more source