Results 11 to 20 of about 10,795 (199)

Drug repurposing screens reveal cell-type-specific entry pathways and FDA-approved drugs active against SARS-Cov-2

Cell Reports, 2021
Summary: There is an urgent need for antivirals to treat the newly emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). To identify new candidates, we screen a repurposing library of ∼3,000 drugs.
Mark Dittmar, Jae Seung Lee, Kanupriya Whig, Elisha Segrist, Minghua Li, Brinda Kamalia, Lauren Castellana, Kasirajan Ayyanathan, Fabian L. Cardenas-Diaz, Edward E. Morrisey, Rachel Truitt, Wenli Yang, Kellie Jurado, Kirandeep Samby, Holly Ramage, David C. Schultz, Sara Cherry   +16 more
doaj   +1 more source

Development of a predictive nomogram for switching immunosuppressive drugs in pediatric liver transplant recipients

Frontiers in Pediatrics, 2023
BackgroundTacrolimus (TAC) is the preferred calcineurin inhibitor (CNI) for pediatric liver transplant recipients. However, some recipients may not achieve the desired therapeutic window concentration of TAC, leading to poor prognosis.
Guangxiang Gu, Guangxiang Gu, Tao Zhou, Zhipeng Zong, Jianjun Zhang   +4 more
doaj   +1 more source

Primary livedoid vasculopathy with livedo reticularis: a report of a case successfully treated with cyclosporine and dapsone

Journal of the Egyptian Women’s Dermatologic Society, 2021
Livedoid vasculopathies are a group of heterogeneous disorders featuring cutaneous ischemia. Common pathological features include perivascular fibrinoid deposition with absence of evident features of vasculitis.
Galal El Enany, Noha Nagui, Hanan Nada, Marwa M Fawzy, Iman Sany, Ahmed Nada, Heba A. Abdel Kader, Omar El Ghanam   +7 more
doaj   +1 more source

The genome of tolypocladium inflatum: evolution, organization, and expression of the cyclosporin biosynthetic gene cluster. [PDF]

PLoS Genetics, 2013
The ascomycete fungus Tolypocladium inflatum, a pathogen of beetle larvae, is best known as the producer of the immunosuppressant drug cyclosporin. The draft genome of T.
Kathryn E Bushley, Rajani Raja, Pankaj Jaiswal, Jason S Cumbie, Mariko Nonogaki, Alexander E Boyd, C Alisha Owensby, Brian J Knaus, Justin Elser, Daniel Miller, Yanming Di, Kerry L McPhail, Joseph W Spatafora   +12 more
doaj   +1 more source

Severe Vulvar and Perianal Crohn’s Disease: A Case Report and Review of the Literature

Case Reports in Dermatology, 2022
Association of vulvar Crohn’s disease (CD) with pyoderma gangrenosum (PG) has been described, yet due to its low prevalence, data on therapeutic management of this association are still limited.
Guillaume Le Cosquer, Alexis Barranca, Louise Lapotre, Eline Casassa, Benoit Chaput, Jonathan Ciron, Louis Buscail, Carle Paul, Cyrielle Gilletta   +8 more
doaj   +1 more source

Pembrolizumab-Induced Toxic Epidermal Necrolysis

Case Reports in Oncology, 2022
Immunotherapy has nowadays become part of the mainstay of treatment for several cancers. In this report, we present a case of toxic epidermal necrolysis (TEN) occurring as a relatively rare complication of pembrolizumab, which is a humanized monoclonal ...
Luca Borg, Malcolm Buhagiar, Elisa La Ferla, David Pisani, Janabel Said, Michael J. Boffa   +5 more
doaj   +1 more source

Rhupus Syndrome Presenting as Interstitial Lung Disease: A Case Report [PDF]

Journal of Clinical and Diagnostic Research, 2021
Systemic Lupus Erythematosus (SLE) and Rheumatoid Arthritis (RA) are characterised by two distinct immunopathological activities, the T-helper 2 cells play a vital role in pathogenesis of SLE while T-helper 1 cells play an important role in RA.
Vishal Venugopal, Srujan Sriram Yelamanchi, Vrinda Vijayakumari, VR Mohan Rao   +3 more
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A case of rhabdomyolysis after atorvastatin therapy of a liver transplant recipient receiving immunosuppressive therapy with cyclosporine

Трансплантология (Москва), 2021
Rationale. To date, liver transplantation is the most effective method of treating end-stage liver failure, and therefore this treatment has become widespread throughout the world.
A. V. Shabunin, S. P. Loginov, P. A. Drozdov, I. V. Nesterenko, D. A. Makeev, O. S. Zhuravel, L. R. Karapetyan   +6 more
doaj   +1 more source

Mechanisms of Action of the Host-Targeting Agent Cyclosporin A and Direct-Acting Antiviral Agents against Hepatitis C Virus

Viruses, 2023
Several direct-acting antivirals (DAAs) are available, providing interferon-free strategies for a hepatitis C cure. In contrast to DAAs, host-targeting agents (HTAs) interfere with host cellular factors that are essential in the viral replication cycle ...
Dandan Liu, Tanya P. Ndongwe, Juan Ji, Andrew D. Huber, Eleftherios Michailidis, Charles M. Rice, Robert Ralston, Philip R. Tedbury, Stefan G. Sarafianos   +8 more
doaj   +1 more source

Proline Isomerization: From the Chemistry and Biology to Therapeutic Opportunities

Biology, 2023
Proline isomerization, the process of interconversion between the cis- and trans-forms of proline, is an important and unique post-translational modification that can affect protein folding and conformations, and ultimately regulate protein functions and
Deepti Gurung, Jacob A Danielson, Afsara Tasnim, Jian-Ting Zhang, Yue Zou, Jing-Yuan Liu   +5 more
doaj   +1 more source