Results 11 to 20 of about 50,966 (210)
Clinics in Dermatology, 1989 Cyclosporine A (CsA) is a neutral lipophilic compound that was first isolated in the 1970s from the fungal species Tolypocladium inflatum gams. CsA is a cyclic polypeptide that consists of 11 amino acids and that has a molecular weight of 1202 daltons.1 It was found to have potent immunosuppressive properties and was initially used in the late 1970s to
Gupta, Aditya K. +7 more
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Proline Isomerization: From the Chemistry and Biology to Therapeutic Opportunities
Biology, 2023 Proline isomerization, the process of interconversion between the cis- and trans-forms of proline, is an important and unique post-translational modification that can affect protein folding and conformations, and ultimately regulate protein functions and
Deepti Gurung +5 more
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A case of long-term tolerance after kidney transplantation
Медицинская иммунология, 2022 We present a case of long-term organ functioning (ca.10 years) after allografting of a cadaveric kidney without usage of immunosuppressing drugs. In 2005, a patient suffering from a hypertensive form of chronic glomerulonephritis, have received an ...
A. A. Korzhenevsky, N. P. Korzhenevskaya
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Successful treatment of a rare variant of mesangioproliferative glomerulonephritis with IgM deposits with Cyclosporin A [PDF]
Терапевтический архив, 2020 We present a case with a rare variant of glomerulonephritis, IgM nephropathy, which occurs mainly with nephrotic syndrome. The clinical features of this variant of kidney damage are characterized; the pathogenetic and the transformation of this form of ...
Daria V. Gurova +4 more
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Cyclosporin inhibits hyperalgesia and edema in arthritic rats: role of the central nervous system [PDF]
Brazilian Journal of Medical and Biological Research, 1997 Since arthritis induced by Mycobacterium products (adjuvant) in rats is considered to be immunologically driven, the objective of the present study was to determine if the immunosuppressor drug cyclosporin could affect hindpaw edema and joint ...
J.N. Francischi +2 more
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Dermatologica Sinica, 2017 Background: Psoriasis is a chronic inflammatory disease that affects the skin, joints, and cardiovascular system. Although a potential association of end-stage renal disease (ESRD) with psoriasis has been demonstrated in patients, the potential for the ...
Sebastian Yu +4 more
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Binding of Different Cyclosporin Variants to Micelles Evidenced by NMR and MD Simulations
Membranes, 2023 Peptides play a critical role in the life of organisms, performing completely different functions. The biological activity of some peptides, such as cyclosporins, can be determined by the degree of membrane permeability.
Polina P. Kobchikova +2 more
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Biomolecules, 2023 Interferon-induced transmembrane proteins (IFITMs) block the fusion of diverse enveloped viruses, likely through increasing the cell membrane’s rigidity.
David Prikryl +5 more
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Indian Dermatology Online Journal, 2021 Background: Stevens-Johnson syndrome and toxic epidermal necrolysis are severe, life-threatening mucocutaneous drug reactions with a high morbidity and mortality that require immediate medical care.
Manisha Balai +5 more
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Lung India, 2014 Pulmonary alveolar proteinosis (PAP) is an orphan disease characterized by the accumulation of excess of surfactant within alveoli and bronchioles. The primary form of PAP (P-PAP; also referred to as idiopathic or autoimmune) is the most common form.
Ashfaq Hasan, Raja Ram, TLN Swamy
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