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Cyclosporine nephrotoxicity

Transplantation Proceedings, 2004
The introduction of cyclosporine (CSA) into organ transplantation was a landmark achievement leading to a substantial improvement of the early transplant results. It was particularly the reduction in early severe acute rejections that accounted for this improvement.
J M, Grinyó, J M, Cruzado
  +7 more sources

Cyclosporin A

Journal of the American Academy of Dermatology, 1986
Cyclosporin A is a new immunosuppressive agent that selectively affects T helper cells without suppressing the bone marrow. Cyclosporin A has been used primarily to prevent rejection in organ transplantation and acute graft-versus-host disease. Studies suggest that it may be of benefit in psoriasis, pemphigus vulgaris, bullous pemphigoid, Behçet's ...
E H, Page, D M, Wexler, L C, Guenther
openaire   +2 more sources

Experience with cyclosporine

Transplantation Proceedings, 2004
The concentration at 2 hours after drug intake (C2) is proposed to optimise clinical outcomes in organ transplantation and for adjustment of the regimen of cyclosporine. A population based pharmacokinetic study was undertaken during the first 30 days post-liver transplantation.
M, Billing-Grima, P, Wolf
openaire   +4 more sources

Cyclosporine immunosuppression

American Journal of Health-System Pharmacy, 1984
The chemistry, pharmacokinetics, mechanism of action, clinical efficacy in organ transplants, adverse effects, and dosage and administration of cyclosporine, a new immunosuppressant, are reviewed. Advice on counseling patients who take the drug is also included. Cyclosporine is a cyclic undecapeptide with a high molecular weight.
D M, Canafax, N L, Ascher
openaire   +2 more sources

Cyclosporine and Myopathy

Annals of Internal Medicine, 1987
Excerpt To the editor: Graves disease with ophthalmopathy was diagnosed in a 37-year-old woman. Treatment consisted of propranolol, 20 mg three times a day, propylthiouracil, 100 mg three times a d...
Noppen, Marc   +4 more
openaire   +2 more sources

Cyclosporine in dermatology

Journal of the American Academy of Dermatology, 1989
Cyclosporine is a potent immunosuppressive agent with no appreciable effect on the bone marrow and a selective inhibitory effect on helper T cells. Oral cyclosporine was first used to prevent organ rejection but also has been reported to be effective in other disorders. In cutaneous diseases that respond to oral cyclosporine helper T cells appear to be
A K, Gupta   +7 more
openaire   +2 more sources

The cyclosporins

Folia Microbiologica, 1995
This review presents the progress and some aspects achieved during recent years with cyclosporin sources, chemistry, biological activities, side effects, biosynthesis and metabolism. Although incomplete the results indicate future research trends and some white spots to be studied in the near future to afford unique insights into cell biology and to ...
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Cyclosporine and Prostaglandins

Annals of Internal Medicine, 1985
Excerpt To the editor: Cyclosporine and its nephrotoxicity have recently been reviewed in your journal (1). Subsequently, Dr.
D, Adu   +4 more
openaire   +2 more sources

Infection and Cyclosporine

Clinical Infectious Diseases, 1989
Cyclosporine is a potent immunosuppressive agent that selectively impairs T cell function. The steady growth of its importance makes knowledge of its activity and effects clinically relevant. The intrinsic antibiotic activity of cyclosporine is limited; although it inhibits certain viruses, fungi, protozoa, and helminths, in practical terms these ...
J H, Kim, J R, Perfect
openaire   +2 more sources

Cyclosporine A in psoriasis

Clinics in Dermatology, 1991
Abstract Cyclosporine A (CyA) is a potent immunosuppressive agent with a selective and reversible inhibitory effect on T-cell functions, especially interleukin-2 production. The drug is not myelotoxic, mutagenic, or teratogenic and is extremely effective in preventing rejection of grafted organs.
openaire   +2 more sources

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