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Clinics in Dermatology, 1989 Cyclosporine A (CsA) is a neutral lipophilic compound that was first isolated in the 1970s from the fungal species Tolypocladium inflatum gams. CsA is a cyclic polypeptide that consists of 11 amino acids and that has a molecular weight of 1202 daltons.1 It was found to have potent immunosuppressive properties and was initially used in the late 1970s to
Gupta, Aditya K. +7 more
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TURKDERM, 2022 Cyclosporine is an immunosuppressive agent used in the treatment of psoriasis. It shows its action through calcineurin inhibition and T-lymphocytes. With its rapid effect, it can be used as an induction therapy in plaque, pustular and erythrodermic psoriasis. Its most common side effects are elevated serum creatinin values and arterial hypertension. In
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Journal of Transplantation, 2012 The discovery and use of cyclosporine since its inception into clinical use in the late 1970s has played a major role in the advancement of transplant medicine. While it has improved rates of acute rejection and early graft survival, data on long-term survival of renal allografts is less convincing.
Lukas Haragsim, Dustin Tedesco
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Cross-reactivities of cyclosporin G (NVa2 cyclosporin) and metabolites in cyclosporin A immunoassays [PDF]
Clinical Chemistry, 1993 Abstract Immunoassays of cyclosporin A (CsA) have been routinely used to measure CsG. We investigated the cross-reactivities of CsG and its metabolites, as well as the proportion CsG constitutes in relation to total drug measured, for six CsG metabolites (GM1, GM9, GM4N, GM1c, GM1c9, GM19) in the following CsA assays: Sandimmune ...
Loralie J. Langman +2 more
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Is Cyclosporine Ototoxic? [PDF]
Frontiers in Neurology, 2020 Cyclosporine was discovered in 1970, it was isolated from the fungus Tolypocladium inflatum in Switzerland (1). Soon after, an immunosuppressive property was suggested, and by 1978, it was used for the first time in human kidney transplantation to treat organ rejection post-transplant (2).
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Solubilization of cyclosporin A [PDF]
AAPS PharmSciTech, 2001 This study investigated the solubilization of cyclosporin A (CsA), a neutral undecapeptide, by cosolvency, micellization, and complexation. Cosolvents (ethanol, propylene glycol, polyethylene glycol, tetrahydrofurfuryl alcohol polyethyleneglycol ether, and glycerin), surfactants (polyoxyethylene sorbitan monooleate [(Tween 80)], polyoxyethylene ...
Yingqing Ran +3 more
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Cyclosporine A inhibits Ca2+-dependent stimulation of the Na+/H+ antiport in human T cells. [PDF]
, 1986 P M Rosoff, Geronimo Terres
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Bromocriptine and low dose cyclosporine in the treatment of experimental autoimmune uveitis in the rat. [PDF]
, 1987 Alan G. Palestine +4 more
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Pneumocystis carinii Pneumonia in Renal-Transplant Recipients Treated with Cyclosporine and Steroids [PDF]
, 1984 A. M. Hardy +4 more
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