Turkderm Turkish Archives of Dermatology and Venereology, 2022 Cyclosporine is an immunosuppressive agent used in the treatment of psoriasis. It shows its action through calcineurin inhibition and T-lymphocytes.
Nahide Onsun
doaj +3 more sources
Safety and efficacy of sirolimus combined with cyclosporine in primary membranous nephropathy: a randomized controlled trial [PDF]
BMC MedicineBackground Calcineurin inhibitors, such as cyclosporine, are primary treatments for membranous nephropathy (MN). Optimizing this regimen is crucial to reduce nephrotoxicity and enhance immunological remission.
Fang Wang +12 more
doaj +2 more sources
A comparative analysis of drug-induced kidney injury adverse reactions between cyclosporine and tacrolimus based on the FAERS database [PDF]
BMC ImmunologyBackground This study utilizes the FDA Adverse Event Reporting System (FAERS) database to compare the adverse reaction signals of cyclosporine and tacrolimus, two widely used immunosuppressants, in relation to drug-induced kidney injury. The findings aim
Min Xu, Shanggang Xu, Xueliang Yi
doaj +2 more sources
Clinical efficacy of 0.05% cyclosporine nano-emulsion in the treatment of dry eye syndrome associated with meibomian gland dysfunction [PDF]
International Journal of Ophthalmology, 2022 AIM: To evaluate the clinical efficacy of topical 0.05% cyclosporine nano-emulsion in the treatment of dry eye syndrome (DES) with meibomian gland dysfunction (MGD).
Yeon Ji Jo, Ji Eun Lee, Jong Soo Lee
doaj +1 more source
Crosstalk between Shh and TGF-β signaling in cyclosporine-enhanced cell proliferation in human gingival fibroblasts. [PDF]
PLoS ONE, 2013 BACKGROUND: Immunosuppressant cyclosporine-A induces gingival hyperplasia, which is characterized by increased fibroblast proliferation and overproduction of extracellular matrix components and regulated by transforming growth factor-beta (TGF-β).
Yi Chung, Earl Fu
doaj +1 more source
Cyclosporine Affects the Main Virulence Factors of Cryptococcus neoformans In Vitro
Journal of Fungi, 2023 This study aimed to investigate the effects of cyclosporine on the morphology, cell wall structure, and secretion characteristics of Cryptococcus neoformans.
Iara Bastos de Andrade +9 more
doaj +1 more source
Clinics in Dermatology, 1989 Cyclosporine A (CsA) is a neutral lipophilic compound that was first isolated in the 1970s from the fungal species Tolypocladium inflatum gams. CsA is a cyclic polypeptide that consists of 11 amino acids and that has a molecular weight of 1202 daltons.1 It was found to have potent immunosuppressive properties and was initially used in the late 1970s to
Gupta, Aditya K. +7 more
openaire +3 more sources
Problems in pharmaceutical compounding of eye-drops with cyclosporine A [PDF]
Farmacja Polska, 2019 Cyclosporine A is very effective in treatment of many ophthalmic pathologies like immunological and inflammatory diseases of the cornea, conjunctive or uvea. It is also used to prevent corneal graft rejection and to treat dry eye syndrome.
Eliza Katarzyna Wolska +2 more
doaj +1 more source
Involvement of oxidative species in cyclosporine-mediated cholestasis
Frontiers in Pharmacology, 2022 Cyclosporine is an established medication for the prevention of transplant rejection. However, adverse consequences such as nephrotoxicity, hepatotoxicity, and cholestasis have been associated with prolonged usage. In cyclosporine-induced obstructive and
Bernard Nsengimana +4 more
doaj +1 more source