Results 11 to 20 of about 79,325 (265)

Cyclosporine A [PDF]

Clinics in Dermatology, 1989
Cyclosporine A (CsA) is a neutral lipophilic compound that was first isolated in the 1970s from the fungal species Tolypocladium inflatum gams. CsA is a cyclic polypeptide that consists of 11 amino acids and that has a molecular weight of 1202 daltons.1 It was found to have potent immunosuppressive properties and was initially used in the late 1970s to
Gupta, Aditya K., Ellis, Charles N., Goldfarb, Michael T., Cooper, Kevin D., Rocher, Leslie, Brown, Marc D., Baadsgaard, Ole, Voorhees, John J.   +7 more
openaire   +3 more sources

A shared mucosal gut microbiota signature in primary sclerosing cholangitis before and after liver transplantation

Hepatology, EarlyView., 2022
In this study of the gut mucosal microbiota in primary sclerosing cholangitis (PSC), we found consistent microbiota features associated with PSC and recurrent PSC, PSC with inflammatory bowel disease and a persistent gut dysbiosis after liver transplantation Abstract Background and Aims Several characteristic features of the fecal microbiota have been ...
Mikal Jacob Hole, Kristin Kaasen Jørgensen, Kristian Holm, Peder R. Braadland, Malin Holm Meyer‐Myklestad, Asle Wilhelm Medhus, Dag Henrik Reikvam, Alexandra Götz, Krzysztof Grzyb, Kirsten Muri Boberg, Tom Hemming Karlsen, Martin Kummen, Johannes R. Hov   +12 more
wiley   +1 more source

Factors associated with cardiovascular events after simultaneous liver–kidney transplant from the US Multicenter Simultaneous Liver–Kidney Transplant Consortium

Hepatology Communications, EarlyView., 2022
Abstract Cardiovascular disease is a leading complication after both liver and kidney transplantation. Factors associated with and rates of cardiovascular events (CVEs) after simultaneous liver–kidney transplant (SLKT) are unknown. This was a retrospective cohort study of adult SLKT recipients between 2002 and 2017 at six centers in six United Network ...
Jennifer Jo, Gonzalo Crespo, Dyanna Gregory, Jasmine Sinha, Jiaheng Xie, Min Zhang, John Magee, Pranab Barman, Yuval A. Patel, Aaron Schluger, Kara Walters, Scott Biggins, Natalia Filipek, Giuseppe Cullaro, Randi Wong, Jennifer C. Lai, Gabriel J. Perreault, Elizabeth C. Verna, Pratima Sharma, Lisa B. VanWagner   +19 more
wiley   +1 more source

Vasospasm is a significant factor in cyclosporine-induced neurotoxicity: Case report

BMC Neurology, 2010
Background The aetiology of central nervous system lesions observed in cerebral cyclosporine neurotoxicity remains controversial. Case presentation We report a 48-year-old woman with a non-severe aplastic anaemia who presented with stroke-like episodes ...
Span Lambert FR, Postma Alida A, Lodder Jan, Braakman Hilde MH, Mess Werner H   +4 more
doaj   +1 more source

Clinical nephrotoxicity induced by cyclosporin A combined with hormone therapy for nephrotic syndrome

Pakistan Journal of Pharmaceutical Sciences, 2021
This study aims to explore the nephrotoxicity due to use of combination of cyclosporine A and hormone in the treatment of nephrotic syndrome. From January 2018 to November 2019, 100 patients with primary nephrotic syndrome were divided into experimental
Xiaoli Liu, Guiying Li, Xin Liu, Yansong Huang, Zhijie Xun, Qian Song, Ruixia Wang, Congmin Wang   +7 more
doaj   +1 more source

Cyclosporine: A Review [PDF]

Journal of Transplantation, 2012
The discovery and use of cyclosporine since its inception into clinical use in the late 1970s has played a major role in the advancement of transplant medicine. While it has improved rates of acute rejection and early graft survival, data on long-term survival of renal allografts is less convincing.
Dustin Tedesco, Lukas Haragsim
openaire   +3 more sources

Cyclosporine protects from intestinal epithelial injury by modulating butyrate uptake via upregulation of membrane monocarboxylate transporter 1 levels

Biochemistry and Biophysics Reports, 2020
Background and aims: A relationship between treatment outcomes and intestinal microbiota in patients with inflammatory bowel diseases has been demonstrated. Cyclosporine treatment leads to rapid improvement in severe ulcerative colitis.
Shinji Ota, Hirotake Sakuraba, Hiroto Hiraga, Shukuko Yoshida, Miwa Satake, Yui Akemoto, Nahoko Tanaka, Rina Watanabe, Maeda Takato, Yasuhisa Murai, Kayo Ueno, Takenori Niioka, Makoto Hayakari, Yoh Ishiguro, Shinsaku Fukuda   +14 more
doaj   +1 more source

Dramatic Deep and Durable Remission of Acute Fulminant Ulcerative Colitis Achieved with Cyclosporine in a Patient Who Failed the Induction Intravenous Phase of Cyclosporine

Case Reports in Gastroenterology, 2021
Medical rescue therapy for patients with severe steroid-refractory ulcerative colitis (UC) consists of intravenous (IV) cyclosporine or infliximab and remains limited.
Alicia Philippou, Anam Rizvi, Adam Steinlauf   +2 more
doaj   +1 more source

Oral administration of ginseng ameliorates cyclosporine-induced pancreatic injury in an experimental mouse model. [PDF]

PLoS ONE, 2013
BACKGROUND: This study was performed to investigate whether ginseng has a protective effect in an experimental mouse model of cyclosporine-induced pancreatic injury.
Sun Woo Lim, Kyoung Chan Doh, Long Jin, Shang Guo Piao, Seong Beom Heo, Yu Fen Zheng, Soo Kyung Bae, Byung Ha Chung, Chul Woo Yang   +8 more
doaj   +1 more source

Changes in the blood cyclosporine level after switching from voriconazole to isavuconazole in a patient with aplastic anemia: insights from physiologically based pharmacokinetic model simulation and the Adverse Event Reporting System database study

Frontiers in Microbiology
IntroductionIsavuconazole, a broad-spectrum triazole approved by the United States Food and Drug Administration (FDA) in 2015, moderately inhibits cytochrome P450 3A4.
Chihiro Shiraishi, Chihiro Shiraishi, Hideo Kato, Hideo Kato, Kazuko Ino, Takuya Iwamoto, Takuya Iwamoto   +6 more
doaj   +1 more source