Results 91 to 100 of about 204,688 (384)

Mild psoriasis as a suitable model for proof‐of‐mechanism in a phase 1B setting: Results from a double‐blind placebo‐controlled trial with guselkumab

British Journal of Clinical Pharmacology, EarlyView.
Aims Early clinical development of novel psoriasis therapies is hampered by a decreasing number of moderate‐to‐severe psoriasis patients eligible for participation in trials since efficacious treatments, such as biologics, have become widely available.
Jannik Rousel, Menthe E. Bergmans, Lisa J. Bruijnincx, Sissi Lin, Tessa Niemeyer‐van der Kolk, Roman Bohoslavsky, Yalçin Yavuz, Naomi B. Klarenbeek, Joke A. Bouwstra, Robert Rissmann, Martijn B. A. van Doorn, the Next‐Generation ImmunoDermatology Consortium (NGID)   +11 more
wiley   +1 more source

Efficacy of cyclosporine for the treatment of Stevens-Johnson syndrome and toxic epidermal necrolysis: Systemic review and meta-analysis

Dermatologica Sinica, 2017
Background: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening reactions, mainly to drug, characterized by epidermal necrosis and mucous membrane ulceration.
Yu-Tsung Chen, Che-Yuan Hsu, Yu-Ning Chien, Woan-Ruoh Lee, Yu-Chen Huang   +4 more
doaj   +1 more source

Steps in immunosuppression for renal transplantation [PDF]

, 1983
The authors provide a historical survey of the immunosuppressive agents that have been used to prevent allograft rejection.
Hakala, TR, Rosenthal, JT, Starzl, TE
core  

Mechanisms of hypertension during and after orthotopic liver transplantation in children [PDF]

, 1989
The aim of this study was to assess the hormonal alterations that may mediate the systemic hypertension that develops in patients during the perioperative period of orthotopic liver transplantation.
Akerstedt, Andrews, Ann Thompson, Arroyo, Bantle, Bantle, Baxter, Baylis, Bellet, Bernardi, Better, Bland, Bomzon, Bonjour, Borland, Busuttil, Cappuccio, Carlos Esquivel, Chrymko, Clement de Clety, Curtis, D. Ryan Cook, Demetrius Ellis, Epstein, Eskay, Filep, Floras, Gaillard, Gardner, Gartner, Gentile, Gerr, Glantz, Graystone, Henriksen, Hiatt, Januszewicz, Kimura, Kohno, Lau, Ledsome, Leslie, Loughran, Lustig, Mason, Minuk, Moss, Murrey, Nakai, Nicholls, Oaks, Ogawa, Palestine, Papadakis, Powell-Jackson, Ring-Larsen, Ring-Larsen, Rosanto, Salazar, Schacter, Seino, Shapiro, Skorecki, Starzl, Stephen Lawless, Task Force on Blood Pressure Control in Children, Thomas Starzl, Thompson, Vacanti, Voorhees, Weidle, Weidmann, Williams   +72 more
core   +1 more source

A Phase III Study of Belatacept Versus Cyclosporine in Kidney Transplants from Extended Criteria Donors (BENEFIT‐EXT Study)

American Journal of Transplantation, 2010
Recipients of extended criteria donor (ECD) kidneys are at increased risk for graft dysfunction/loss, and may benefit from immunosuppression that avoids calcineurin inhibitor (CNI) nephrotoxicity.
A. Durrbach, J. O. Pestana, T. Pearson, F. Vincenti, V. Garcia, J. Campistol, M. Rial, S. Florman, A. Block, G. Russo, J. Xing, P. Garg, J. Grinyo   +12 more
semanticscholar   +1 more source

Innovative transdermal drug delivery systems: Benefits, challenges, and emerging application

BMEMat, EarlyView.
The graphical abstract illustrates the diverse nanostructures employed in transdermal drug delivery systems, highlighting their unique mechanisms to penetrate the intricate layers of skin. It provides a detailed representation of the skin's complex anatomy, emphasizing the challenges posed by its barrier properties.
Syed Waqas Ali Shah, Xingxing Li, Hao Yuan, Huiling Shen, Shaohao Quan, Guifang Pan, Muhammad Ishfaq, Abid Ullah Shah, Hanhan Xie, Jundong Shao   +9 more
wiley   +1 more source

Pharmacokinetic Disposition Difference Between Cyclosporine and Voclosporin Drives Their Distinct Efficacy and Safety Profiles in Clinical Studies

Clinical Pharmacology: Advances and Applications, 2020
Yan Li,1 Maria Palmisano,1 Duxin Sun,2 Simon Zhou1 1Translational Development and Clinical Pharmacology, Celgene Corporation, Summit, NJ 07920, USA; 2Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109,
Li Y, Palmisano M, Sun D, Zhou S
doaj  

Voclosporin‐induced gingival enlargement: A case report

Clinical Advances in Periodontics, EarlyView.
Abstract Background Drug‐influenced gingival enlargement (DIGE) is a recognized adverse effect of certain medications, particularly immunosuppressants like cyclosporin and tacrolimus. However, there have been no documented cases of DIGE associated with voclosporin, a newer calcineurin inhibitor used primarily to treat lupus nephritis.
Francesca Racca, Jessica M. Greco, Dimitris N. Tatakis   +2 more
wiley   +1 more source

Comparison of Doppler ultrasonographic indices before and after cyclosporine A peak serum level in stable kidney transplanted recipients

فصلنامه دانشگاه علوم پزشکی جهرم, 2015
Comparison of Doppler ultrasonographic indices before and after cyclosporine A peak serum level in stable kidney transplanted recipients Abstract: Background: Doppler ultrasonography is the best tool for assessment of transplanted kidneys’ vascular ...
zohreh makki, sarir nazemi, Ahmad Enhesari, Jalal Azmandian, saeid Mardpur   +4 more
doaj  

Long-term responses and outcomes following immunosuppressive therapy in large granular lymphocyte leukemia-associated pure red cell aplasia: a Nationwide Cohort Study in Japan for the PRCA Collaborative Study Group

Haematologica, 2008
Large granular lymphocyte leukemia-associated pure red cell aplasia accounts for a significant portion of secondary pure red cell aplasia cases. However, because of its rarity, long-term responses and relapse rates after immunosuppressive therapy are ...
Naohito Fujishima, Ken-ichi Sawada, Makoto Hirokawa, Kazuo Oshimi, Koichi Sugimoto, Akira Matsuda, Masanao Teramura, Masamitsu Karasawa, Ayako Arai, Yuji Yonemura, Shinji Nakao, Akio Urabe, Mitsuhiro Omine, Keiya Ozawa   +13 more
doaj   +1 more source