Results 81 to 90 of about 142,539 (313)
Drug Critical Limits for Urgent Physician Notification
Clinical Pharmacology &Therapeutics, EarlyView.Critical limits represent quantitative decision thresholds for drugs that require immediate clinician notification and potential life‐saving intervention. United States hospitals lack a national standard for drug critical limits. We collected critical limits from 417 US hospitals across all 50 states and Washington, D.C.; of these, 411 maintained drug ...
Elina Kuang +3 more
wiley +1 more source
Saudi Journal of Kidney Diseases and Transplantation, 2009 Cyclosporine is the main immunosuppressive drug used for renal transplant reci-pients in order to prevent transplant rejection. Although the drug has increased the survival of patients and grafted organ, it has some side effects independent of its effect
Ahmadi Farrokhlagha +2 more
doaj
Dermatologica Sinica, 2017 Background: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening reactions, mainly to drug, characterized by epidermal necrosis and mucous membrane ulceration.
Yu-Tsung Chen +4 more
doaj +1 more source
A Review of Virtual Twins in Physiologically‐Based Pharmacokinetic Modeling and Simulation
Clinical Pharmacology &Therapeutics, EarlyView.The novel application of Virtual Twins (VT) in PBPK (VT‐PBPK) presents the opportunity to advance precision dosing and accelerate the shift from one‐size‐fits‐all to targeted, individualized treatments. This review aims to: (1) critically evaluate existing research on the use of VTs in PBPK, (2) develop a conceptual definition of VT‐PBPK, (3) describe ...
Emily Mannix +4 more
wiley +1 more source
Clinical Pharmacology: Advances and Applications, 2020 Yan Li,1 Maria Palmisano,1 Duxin Sun,2 Simon Zhou1 1Translational Development and Clinical Pharmacology, Celgene Corporation, Summit, NJ 07920, USA; 2Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109,
Li Y, Palmisano M, Sun D, Zhou S
doaj
Histopathological Study of Cyclosporine Pulmonary Toxicity in Rats
Journal of Toxicology, 2016 Cyclosporine is considered one of the common worldwide immunosuppressive drugs that are used for allograft rejection prevention. However, articles that address adverse effects of cyclosporine use on the vital organs such as lung are still few. This study
Said Said Elshama +2 more
doaj +1 more source
Cyclosporine is a potential curative treatment option for advanced thymoma
Experimental Hematology & Oncology, 2017 Background Thymectomy can effectively cure most thymoma patients; however, patients with advanced thymoma typically require chemotherapy, which is associated with limited efficacy in this context.
Yusuke Isshiki +3 more
doaj +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Traditional dosing strategies often rely on a “one‐size‐fits‐all” paradigm, assuming an “average” patient with typical demographic and pharmacological characteristics. In reality, this often overlooks existing between‐patient variability and can lead to suboptimal drug exposure or toxicity. This issue is especially pronounced in pediatric patients, who
Zachary L. Taylor +12 more
wiley +1 more source
Ciclosporina: riscos em idade pediátrica.
Acta Médica Portuguesa, 2010 Cyclosporine has been found to be effective and safe in many inflammatory skin disorders such as psoriasis and atopic dermatitis (AD), in adults and in children. Its use in paediatrics is still under scope.
João Antunes +2 more
doaj +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Coproporphyrin I (CPI) is an established endogenous biomarker for detecting drug–drug interactions (DDIs) involving the hepatic uptake transporter Organic Anion Transporting Polypeptide 1B1 (OATP1B1, gene SLCO1B1). While CPI has been extensively studied in healthy volunteers using controlled pre‐ and post‐OATP1B1‐inhibitor sampling, its applicability ...
Leila Potzel +9 more
wiley +1 more source