Results 81 to 90 of about 102,207 (305)

Cyclosporine is a potential curative treatment option for advanced thymoma

open access: yesExperimental Hematology & Oncology, 2017
Background Thymectomy can effectively cure most thymoma patients; however, patients with advanced thymoma typically require chemotherapy, which is associated with limited efficacy in this context.
Yusuke Isshiki   +3 more
doaj   +1 more source

腎臟移植病人不同calcineurin抑制劑對sirolimus藥動學之影響

open access: yes, 2009
Study Objective. To compare the effects of different calcineurin inhibitors on sirolimus pharmacokinetics during chronic staggered administration in kidney transplant recipients. Design. Randomized, open- label, parallel-group trial Setting.
林慧玲;蔡孟昆;陳瑞龍;孫紹文;黃金鼎;胡瑞恆;陳國鋅;李伯皇   +1 more
core  

Cyclosporine-A induced cytotoxicity within HepG2 cells by inhibiting PXR mediated CYP3A4/CYP3A5/MRP2 pathway

open access: yes
Cyclosporine-A (CsA) is currently used to treat immune rejection after organ transplantation as a commonly used immunosuppressant. Liver injury is one of the most common adverse effects of CsA, whose precise mechanism has not been fully elucidated ...
Fan Zhou (196667)   +7 more
core   +1 more source

Successful Co‐Administration of Secukinumab and Dupilumab in a Patient With Psoriasis and Paradoxical Atopic Dermatitis

open access: yesJEADV Clinical Practice, EarlyView.
ABSTRACT Paradoxical atopic dermatitis (AD) can arise during biologic therapy for psoriasis due to an immune‐axis imbalance. We describe a 47‐year‐old man who developed severe AD while receiving secukinumab, which was successfully managed with the addition of dupilumab, allowing long‐term control of both diseases.
So Yun Park   +6 more
wiley   +1 more source

Ciclosporina: riscos em idade pediátrica.

open access: yesActa Médica Portuguesa, 2010
Cyclosporine has been found to be effective and safe in many inflammatory skin disorders such as psoriasis and atopic dermatitis (AD), in adults and in children. Its use in paediatrics is still under scope.
João Antunes   +2 more
doaj   +1 more source

The Clearance of Cyclosporine by Hemodialysis [PDF]

open access: yes, 1984
: The pharmacokinetics of cyclosporine were studied in five liver transplant patients when they were on and off hemodialysis. There was no significant difference in the blood clearance of cyclosporine between these two periods.
PTACHCINSKI, RICHARD J   +17 more
core   +1 more source

When Treatment Meets Natural History: Understanding Early Dermatitis‐Related Adverse Events in Systemic Atopic Dermatitis Trials

open access: yesJEADV Clinical Practice, EarlyView.
ABSTRACT Biologics and Janus kinase (JAK) inhibitors have transformed the management of atopic dermatitis (AD), yet some patients experience early worsening of disease activity during treatment initiation. In clinical trials, these events are typically recorded as treatment‐emergent adverse events (TEAEs), most commonly coded as “atopic dermatitis”. We
Diego Ruiz Dasilva   +17 more
wiley   +1 more source

Relation of magnesium level to cyclosporine and metabolic complications in renal transplant recipients

open access: yesSaudi Journal of Kidney Diseases and Transplantation, 2009
Cyclosporine is the main immunosuppressive drug used for renal transplant reci-pients in order to prevent transplant rejection. Although the drug has increased the survival of patients and grafted organ, it has some side effects independent of its effect
Ahmadi Farrokhlagha   +2 more
doaj  

Pharmacokinetic Disposition Difference Between Cyclosporine and Voclosporin Drives Their Distinct Efficacy and Safety Profiles in Clinical Studies

open access: yesClinical Pharmacology: Advances and Applications, 2020
Yan Li,1 Maria Palmisano,1 Duxin Sun,2 Simon Zhou1 1Translational Development and Clinical Pharmacology, Celgene Corporation, Summit, NJ 07920, USA; 2Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109,
Li Y, Palmisano M, Sun D, Zhou S
doaj  

Health claims database study of cyclosporine ophthalmic emulsion treatment patterns in dry eye patients

open access: yes, 2013
Karl G Stonecipher,1 Jenny Chia,2 Ahunna Onyenwenyi,2 Linda Villanueva,2 David A Hollander2 1TLC Laser Eye Centers, Greensboro, NC, 2Allergan, Inc., Irvine, CA, USA Background: Dry eye is a multifactorial, symptomatic disease associated with ocular ...
Hollander DA   +4 more
core  

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