Results 91 to 100 of about 142,539 (313)

Induction of cytochrome P450 2C9 and P‐glycoprotein activity by antiseizure medications: A systematic review and network meta‐analysis

Epileptic Disorders, EarlyView.
Abstract Objectives Antiseizure medications (ASMs) can induce the activity of drug‐metabolizing enzymes and drug transporters, including cytochrome P450 (CYP)2C9 and P‐glycoprotein (P‐gp). Our objective was to comparatively assess the effects of ASMs on exposure to clinical CYP2C9 and P‐gp substrates.
Hagar Cohen, Nahawand Bahash, Tomer Ben‐Shushan, Ilan Matok, Sara Eyal   +4 more
wiley   +1 more source

Safety and efficacy of sirolimus combined with cyclosporine in primary membranous nephropathy: a randomized controlled trial

BMC Medicine
Background Calcineurin inhibitors, such as cyclosporine, are primary treatments for membranous nephropathy (MN). Optimizing this regimen is crucial to reduce nephrotoxicity and enhance immunological remission.
Fang Wang, Chao Yang, Yue Shu, Cai-xia Lin, Yao Yao, Yue Li, Yi-miao Zhang, Xin Wang, Li-qiang Meng, Xu-yang Cheng, Gang Liu, Ming-hui Zhao, Zhao Cui   +12 more
doaj   +1 more source

A Comprehensive Review on Nutrition, Phytochemistry, Pharmacology and Food Application Perspectives of Bioactive Rich Superfruits

Future Postharvest and Food, EarlyView.
The review critically evaluated and compared the selected superfruit phytochemistry, their bioactive composition and the key health benefits majorly emphasizing the antioxidant potential. It has highlighted the translational challenges in formulating functional foods by addressing the issues related to delivery system, bioavailability mechanism and the
Sharath Kumar Nagaraja, Javid Iqbal Mir, Mahendra Kumar Verma, Aamir Hussain Dar   +3 more
wiley   +1 more source

Comparison of the cyclosporine variants A and D by NMR spectroscopy

Учёные записки Казанского университета: Серия Естественные науки, 2019
A natural variant of cyclosporine A, cyclosporine D, has been studied using high-resolution NMR spectroscopy in a non-polar solution (chloroform). A complete assignment of the 1H and 13C NMR signals has been made.
P.P. Kobchikova, Yu.O. Zgadzay, S.V. Efimov, V.V. Klochkov   +3 more
doaj   +1 more source

Cyclosporine nephrotoxicity

Cleveland Clinic Journal of Medicine, 1989
Cyclosporine is a potent and useful immunosuppressive agent used primarily in conjunction with solid organ transplantation. The most serious adverse reaction that limits its use is nephrotoxicity due to effects on the renal vasculature, glomeruli, and tubular function. These effects result in a variety of clinical syndromes.
openaire   +2 more sources

Propofol‐induced hypertriglyceridemia in critically ill trauma patients requiring nutrition therapy: A descriptive cohort study

Journal of Parenteral and Enteral Nutrition, EarlyView.
Abstract Background This study aimed to assess the incidence and identify risk factors associated with the development of propofol‐induced hypertriglyceridemia in critically ill trauma patients who required nutrition therapy. Methods Adult patients (aged >17 years) admitted to the trauma intensive care unit who received propofol for >24 h and had a ...
Emma S. Lemke, Jonathon K. Walker, Julie E. Farrar, Saskya Byerly, Dina M. Filiberto, Roland N. Dickerson   +5 more
wiley   +1 more source

Assessment of the efficiency of cyclosporine use in psoriasis [PDF]

Саратовский научно-медицинский журнал, 2017
The article presents a review of randomized studies involving patients with severe psoriasis, which showed that after 10-12 weeks of monotherapy with cyclosporine there was a decline of the Index of prevalence and severity of psoriasis (PASI).
Kruglova L.S., Ponich E.S., Osina A.V., Gryazeva N.V.   +3 more
doaj  

Pregnancy after liver transplantation under tacrolimus [PDF]

, 1997
Background. The maternal and fetal risk of pregnancy after organ transplantation under tacrolimus has not been reported. This was prospectively studied in 27 pregnancies by 21 female liver recipients who were treated with tacrolimus before and throughout
Armenti, Ashok Jain, Bourget, Bourget, Bumgardner, Davison, Fung, Grenier, Guignard, Hamill, J. Carlton Gartner, Jackie Lever, Jain, John J. Fung, Klintmalm, Laifer, Lubchenco, McCauley, Metha, Penn, Radomski, Radomski, Raman Venkataramanan, Satlin, Scantlebury, Shaheen, Starzl, Starzl, The, The European, Thomas E. Starzl, Todo, Venkataramanan, Vijay Warty, Vijayan Balan, Warty, Winkler   +36 more
core   +1 more source

Long‐term outcomes of children with ulcerative colitis after acute severe colitis: A GETAID pédiatrique multicenter study

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Acute severe colitis (ASC) is a frequent and severe complication of ulcerative colitis (UC) with a high risk of colectomy. Effects of immunosuppressants and anti–tumor necrosis factor (anti‐TNF) agents on the risk of colectomy remain debated. We wished to study the evolution of French pediatric‐onset UC patients after ASC.
Manon Cochet, Agathe Beauvais, Frank Ruemmele, Raphael Enaud, Thierry Lamireau, Rémi Duclaux‐Loras, Claire Dupont, Stéphanie Willot, Laure Bridoux‐Henno, Georges Dimitrov, Julie Lemale, Vincent Guinard‐Samuel, Valérie Bertrand, Anne Breton, Christine Martinez Vinson, Stéphanie Coopman, Delphine Ley, Bénédicte Pigneur, and the Groupe d'Etudes Thérapeutiques des Affections Inflammatoires du tube Digestif (GETAID) pédiatrique   +18 more
wiley   +1 more source

Surgical Reconstruction in Pyoderma Gangrenosum, a Retrospective Study of Five Patients

JEADV Clinical Practice, EarlyView.
ABSTRACT Pyoderma Gangrenosum (PG) is a neutrophilic dermatosis characterized by chronic painful ulcerations most commonly on the lower extremities. Current treatment options for PG are largely nonsurgical and include the use of systemic and topical immunomodulators and wound care.
Max E. Oscherwitz, Alysia B. Kohrs, Jacob C. Maus, Matthew L. Hrin, Maria C. Mariencheck, Joseph L. Jorizzo, Kyle E. Robinson, Joseph A. Molnar, Lindsay C. Strowd   +8 more
wiley   +1 more source