Results 101 to 110 of about 204,688 (384)

A prospective randomized trial of FK506-based immunosuppression after renal transplantation [PDF]

, 1995
A group of 204 adult patients was entered into a prospective, randomized trial comparing FK506/pred-nisone with FK506/azathioprine/prednisone after renal transplantation between August 1, 1991 and October 11,1992.
Demetris, AJ, Fung, JJ, Hakala, TR, Irish, W, Jordan, ML, McCauley, J, Mitchell, S, Randhawa, P, Scantlebury, VP, Shapiro, R, Simmons, RL, Starzl, TE, Vivas, C   +12 more
core   +1 more source

Theoretical Analysis of d‐Serine and d‐Asparagine as Biomarkers for Glomerular Filtration Rate

Chemistry &Biodiversity, EarlyView.
ABSTRACT Chronic kidney disease (CKD) is a major global health issue, requiring accurate and noninvasive renal function assessment. Glomerular filtration rate (GFR) is the standard measure, but current methods, including inulin clearance and creatinine‐based estimation, have limitations in accuracy, invasiveness, and practicality.
Ryo Tanaka, Yoichi Kakuta, Norio Nonomura, Tomonori Kimura   +3 more
wiley   +1 more source

Relation of magnesium level to cyclosporine and metabolic complications in renal transplant recipients

Saudi Journal of Kidney Diseases and Transplantation, 2009
Cyclosporine is the main immunosuppressive drug used for renal transplant reci-pients in order to prevent transplant rejection. Although the drug has increased the survival of patients and grafted organ, it has some side effects independent of its effect
Ahmadi Farrokhlagha, Naseri Rozita, Lessan-Pezeshki Mahbob   +2 more
doaj  

Microbiome‐Informed Dosing: Exploring Gut Microbial Communities Impact on Mycophenolate Enterohepatic Circulation and Therapeutic Target Achievement

Clinical Pharmacology &Therapeutics, EarlyView.
Pharmacomicrobiomics is an emerging field due to important microbiome effects on pharmacokinetics and clinical outcomes. However, the application of this knowledge remains limited. Mycophenolic acid (MPA) is the primary active metabolite of the immunosuppressant, mycophenolate mofetil (MMF).
Abdelrahman Saqr, Shen Cheng, Mahmoud Al‐Kofahi, Christopher Staley, Pamala A. Jacobson   +4 more
wiley   +1 more source

Blood Protein Binding of Cyclosporine in Transplant Patients [PDF]

, 1987
The objective of this study was to compare the binding of cyclosporine to blood proteins between four healthy subjects and five liver and eight renal transplant patients.
Garrett, LeMaire, Niederberger, Ptachcinski, Rosano, Saudie, Solubilization techniques, Somer, Trung, Vallner   +9 more
core   +1 more source

Advancing Predictions of Oral Drug Absorption, CYP3A4 Induction, and Transporter‐Mediated Interactions Using a Human Primary Intestinal 3D Model (EpiIntestinal™)

Clinical Pharmacology &Therapeutics, EarlyView.
Accurate prediction of oral drug absorption in humans is essential for early drug development; however, physiologically relevant human models are lacking. This study aims to comprehensively assess the EpiIntestinal™, a human primary intestinal 3D model, for its ability to predict oral absorption (Fa), intestinal availability (Fg), CYP3A4 induction, and
Paresh P. Chothe, Andrea Whitcher‐Johnstone, Aniruddha Karve, Diane Ramsden, Niresh Hariparsad   +4 more
wiley   +1 more source

Cyclosporine is a potential curative treatment option for advanced thymoma

Experimental Hematology & Oncology, 2017
Background Thymectomy can effectively cure most thymoma patients; however, patients with advanced thymoma typically require chemotherapy, which is associated with limited efficacy in this context.
Yusuke Isshiki, Hiroaki Tanaka, Yoshio Suzuki, Yukihiro Yoshida   +3 more
doaj   +1 more source

Results of an International, Randomized Trial Comparing Glucose Metabolism Disorders and Outcome with Cyclosporine Versus Tacrolimus

American Journal of Transplantation, 2007
DIRECT (Diabetes Incidence after Renal Transplantation: Neoral C2 Monitoring Versus Tacrolimus) was a 6‐month, open‐label, randomized, multicenter study which used American Diabetes Association/World Health Organization criteria to define glucose ...
F. Vincenti, S. Friman, E. Scheuermann, L. Rostaing, T. Jenssen, J. Campistol, K. Uchida, M. Pescovitz, P. Marchetti, M. Tuncer, F. Citterio, A. Więcek, S. Chadban, M. El-Shahawy, K. Budde, N. Goto   +15 more
semanticscholar   +1 more source

Clinical impact of follow‐up endomyocardial biopsy in myocarditis during or after immune‐suppressive therapy

ESC Heart Failure, EarlyView.
Results and clinical implication of repeat endomyocardial biopsy (EMB). Abstract Aims While the diagnostic role of endomyocardial biopsy (EMB) in myocarditis is unquestioned, little is known about its indications and clinical value during long‐term follow‐up.
Anna Baritussio, Andrea Silvio Giordani, Stefania Rizzo, Cristina Vicenzetto, Monica De Gaspari, Elisa Carturan, Giuseppe Toscano, Federico Scognamiglio, Giuseppe Tarantini, Sabino Iliceto, Cristina Basso, Renzo Marcolongo, Alida Linda Patrizia Caforio   +12 more
wiley   +1 more source

Ciclosporina: riscos em idade pediátrica.

Acta Médica Portuguesa, 2010
Cyclosporine has been found to be effective and safe in many inflammatory skin disorders such as psoriasis and atopic dermatitis (AD), in adults and in children. Its use in paediatrics is still under scope.
João Antunes, Catarina Gouveia, Maria João Brito   +2 more
doaj   +1 more source