Results 11 to 20 of about 86,527 (148)
Characterizing the folding core of the cyclophilin A - cyclosporin A complex I: hydrogen exchange data and rigidity analysis [PDF]
Biophys J. 108, 1739-1746 (2015), 2014 The determination of a 'folding core' can help to provide insight into the structure, flexibility, mobility and dynamics, and hence, ultimately, function of a protein - a central concern of structural biology. Changes in the folding core upon ligand binding are of particular interest because they may be relevant to drug-induced functional changes ...
arxiv +2 more sources
Integration of Omics Data and Systems Biology Modeling: Effect of Cyclosporine A on the Nrf2 Pathway in Human Renal Kidneys Cells [PDF]
BMC Systems Biology, 2014, 8:76, 2013 In a recent paper, Wilmes et al. demonstrated a qualitative integration of omics data streams to gain a mechanistic understanding of cyclosporine A toxicity. One of their major conclusions was that cyclosporine A strongly activates the nuclear factor (erythroid-derived 2)-like 2 pathway (Nrf2) in renal proximal tubular epithelial cells exposed in vitro.
arxiv +1 more source
Time-dependent Clearance of Cyclosporine in Adult Renal Transplant Recipients: A Population Pharmacokinetic Perspective [PDF]
arXiv, 2021 Aim The pharmacokinetic (PK) properties of cyclosporine (CsA) in renal transplant recipients are patient- and time-dependent. Knowledge of this time-related variability is necessary to maintain or achieve CsA target exposure. Here, we aimed to identify factors explaining variabilities in CsA PK properties and characterise time-dependent clearance (CL/F)
arxiv
Perfect Echo HMQC: Sensitivity and Resolution Enhancement by Broadband Homonuclear Decoupling [PDF]
, 2013 Homonuclear 1H-1H J-modulation leads to J-multiplets in F1 dimension of 2D 1H-13C HMQC spectra. This hampers unambiguous signal assignment for overcrowded 13C spectra. Broadband homonuclear decoupling has been achieved in the indirect t1 evolution period by incorporating blocks of perfect echo.
arxiv +1 more source
TOXIC EFFECTS OF CYCLOSPORINE ON THE ENDOCRINE PANCREAS OF WISTAR RATS
, 1986 Hans-Jürgen Hahn +5 more
openalex +1 more source
Results of a national interlaboratory quality assessment of cyclosporine assays. [PDF]
, 1988 Giuseppe Zucchelli +4 more
openalex +1 more source
Cyclosporine Treatment of Fulminant Colitis
, 1989 Jeffrey S. Hyams, William R. Treem
openalex +1 more source