Results 11 to 20 of about 14,435 (202)
Breaking into nature's secret medicine cabinet: lichens – a biochemical goldmine ready for discovery [PDF]
New Phytologist, Volume 246, Issue 2, Page 437-449, April 2025.Summary Secondary metabolites are a crucial source of bioactive compounds playing a key role in the development of new pharmaceuticals. Recently, biosynthetic research has benefited significantly from progress on various fronts, including reduced sequencing costs, improved genome/metabolome mining strategies, and expanding tools/databases to compare ...
Garima Singh +3 more
wiley +2 more sources
Epilepsia Open, EarlyView., 2022 Abstract The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force initiated the TASK3 working group to create common data elements (CDEs) for various aspects of preclinical epilepsy research studies, which could help improve the standardization of experimental designs.
Eleonora Aronica +6 more
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Characterizing the folding core of the cyclophilin A - cyclosporin A complex I: hydrogen exchange data and rigidity analysis [PDF]
Biophys J. 108, 1739-1746 (2015), 2014 The determination of a 'folding core' can help to provide insight into the structure, flexibility, mobility and dynamics, and hence, ultimately, function of a protein - a central concern of structural biology. Changes in the folding core upon ligand binding are of particular interest because they may be relevant to drug-induced functional changes ...
arxiv +2 more sources
TURKDERM, 2022 Cyclosporine is an immunosuppressive agent used in the treatment of psoriasis. It shows its action through calcineurin inhibition and T-lymphocytes. With its rapid effect, it can be used as an induction therapy in plaque, pustular and erythrodermic psoriasis. Its most common side effects are elevated serum creatinin values and arterial hypertension. In
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Journal of Transplantation, 2012 The discovery and use of cyclosporine since its inception into clinical use in the late 1970s has played a major role in the advancement of transplant medicine. While it has improved rates of acute rejection and early graft survival, data on long-term survival of renal allografts is less convincing.
Lukas Haragsim, Dustin Tedesco
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The Journal of Dermatology, Volume 50, Issue 1, Page 3-11, January 2023., 2023 Abstract The Japanese Society for Psoriasis Research (JSPR) has been conducting annual epidemiological surveys of patients with pustular psoriasis in Japan since 2017. This study aimed to conduct a recent epidemiological analysis of patients with pustular psoriasis who were enrolled in the JSPR from 2017 to 2020.
Koji Kamiya, Mamitaro Ohtsuki
wiley +1 more source
The Journal of Dermatology, Volume 50, Issue 1, Page 12-25, January 2023., 2023 Abstract The Japanese Society for Psoriasis Research (JSPR) conducted annual epidemiological surveys of patients with psoriatic arthritis (PsA). This study aimed to analyze a recent epidemiological survey of enrolled PsA patients in the JSPR from 2017 to 2020.
Koji Kamiya, Mamitaro Ohtsuki
wiley +1 more source
Cross-reactivities of cyclosporin G (NVa2 cyclosporin) and metabolites in cyclosporin A immunoassays [PDF]
Clinical Chemistry, 1993 Abstract Immunoassays of cyclosporin A (CsA) have been routinely used to measure CsG. We investigated the cross-reactivities of CsG and its metabolites, as well as the proportion CsG constitutes in relation to total drug measured, for six CsG metabolites (GM1, GM9, GM4N, GM1c, GM1c9, GM19) in the following CsA assays: Sandimmune ...
Loralie J. Langman +2 more
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The patient's path to AD: a study of patients adherence to therapy
Медицинский совет, 2020 Introduction. Atopic dermatitis (AD) is one of the most common skin diseases. The prevalence of atopic dermatitis among children is up to 20%, among adults - 2-8%. According to the form, there are mild, moderate and severe AD.
L. S. Kruglova, N. V. Griazeva
doaj +1 more source
Integration of Omics Data and Systems Biology Modeling: Effect of Cyclosporine A on the Nrf2 Pathway in Human Renal Kidneys Cells [PDF]
BMC Systems Biology, 2014, 8:76, 2013 In a recent paper, Wilmes et al. demonstrated a qualitative integration of omics data streams to gain a mechanistic understanding of cyclosporine A toxicity. One of their major conclusions was that cyclosporine A strongly activates the nuclear factor (erythroid-derived 2)-like 2 pathway (Nrf2) in renal proximal tubular epithelial cells exposed in vitro.
arxiv +1 more source