Results 11 to 20 of about 2,768 (247)

Cyclosporine A [PDF]

Clinics in Dermatology, 1989
Cyclosporine A (CsA) is a neutral lipophilic compound that was first isolated in the 1970s from the fungal species Tolypocladium inflatum gams. CsA is a cyclic polypeptide that consists of 11 amino acids and that has a molecular weight of 1202 daltons.1 It was found to have potent immunosuppressive properties and was initially used in the late 1970s to
Gupta, Aditya K., Ellis, Charles N., Goldfarb, Michael T., Cooper, Kevin D., Rocher, Leslie, Brown, Marc D., Baadsgaard, Ole, Voorhees, John J.   +7 more
openaire   +3 more sources

Peptidyl-prolyl cis-trans isomerases (immunophilins) and their roles in parasite biochemistry, host-parasite interaction and antiparasitic drug action. [PDF]

, 2006
Immunophilin is the collective name given to the cyclophilin and FK506-binding protein (FKBP) families. As the name suggests, these include the major binding proteins of certain immunosuppressive drugs: cyclophilins for the cyclic peptide cyclosporin A ...
Adams, Aliberti, Alphey, Angus Bell, Antony P. Page, Argaet, Banerjee, Banumathy, Belfiore, Bell, Bell, Bell, Berriman, Blumenthal, Blumenthal, Borel, Bozdech, Braun, Bua, Carlton, Chakraborty, Chakraborty, Chappell, Chappell, Cianciotto, Cohen, Colgan, Dao-Thi, Denkers, Dobson, Dolinski, Dornan, Dornan, Dutta, Fischer, Florens, Galat, Galat, Gavigan, Gavigan, Gilleard, Golding, Hacker, Hall, High, Hirtzlin, Hong, Hope, Kamath, Kay, Ke, Khattab, Kiang, Klinkert, Klinkert, Knobloch, Kumar, Kumar, Kumar, Le Roch, Lightowlers, Lorberg, Ma, Ma, Ma, Matsuda, McLauchlan, Mikol, Monaghan, Monaghan, Moro, Osman, Ostoa-Saloma, Oz, Page, Page, Page, Page, Page, Page, Page, Paul Monaghan, Pelle, Pereira, Peterson, Picken, Pratt, Rascher, Reddy, Riggs, Rossi, Shirane, Silverman, Taylor, Tuo, Valle, Wang, Weiwad, Williams, Yarovinsky, Yu, Zorio   +101 more
core   +1 more source

The patient's path to AD: a study of patients adherence to therapy

Медицинский совет, 2020
Introduction. Atopic dermatitis (AD) is one of the most common skin diseases. The prevalence of atopic dermatitis among children is up to 20%, among adults - 2-8%. According to the form, there are mild, moderate and severe AD.
L. S. Kruglova, N. V. Griazeva
doaj   +1 more source

V101L of human formyl peptide receptor 1 (FPR1) increases receptor affinity and augments the antagonism mediated by cyclosporins

Biochemical Journal, 2013
Genetic variation plays a major role in drug response variability. CsA (cyclosporin A), a widely used immunosuppressive agent, is a specific antagonist for FPR1 (formyl peptide receptor 1), which is an important G-protein-coupled chemoattractant receptor
Cai-hong Zhou, Yan Zhou, Jia Wang, Yang Feng, Haonan Wang, Jing-lun Xue, Yani Chen, R. Ye, Ming-Wei Wang   +8 more
semanticscholar   +1 more source

A Review on Macrophage Activation Syndrome

Journal of Pure and Applied Microbiology, 2019
MAS, which is currently grouped under secondary or acquired haemophagocytic lymphohistiocytosis (sHLH), is a rare and fatal disorder that results from excess activation of T-cells and macrophages.
Preeti Sharma, Shailza Shreshtha, Pradeep Kumar, Rachna Sharma, T.K. Mahapatra   +4 more
doaj   +1 more source

Competitive interaction of cyclosporins with the Vinca alkaloid-binding site of P-glycoprotein in multidrug-resistant cells.

Journal of Biological Chemistry, 1990
The mechanism of reversal of resistance to Vinca alkaloids by cyclosporins is unclear. We investigated the molecular mechanism of reversal of Vinca alkaloid resistance by cyclosporin A (CsA) and its nonimmunosuppressive analog O-acetyl C9(1) CsA (SDZ 33 ...
I. Tamai, A. Safa
semanticscholar   +1 more source

Modification of cytotoxic drug resistance by non-immuno-suppressive cyclosporins.

British Journal of Cancer, 1988
We have examined the ability of a series of non- or minimally-immunosuppressive analogues of cyclosporin A to modify cytotoxic drug resistance in vitro.
P. Twentyman
semanticscholar   +1 more source

Eukaryotic initiation factor 5A dephosphorylation is required for translational arrest in stationary phase cells [PDF]

, 2013
The protein known as eIF5A (eukaryotic initiation factor 5A) has an elusive role in translation. It has a unique and essential hypusine modification at a conserved lysine residue in most eukaryotes.
Castilho, Beatriz A., Chung, Janete, Rocha, Antonio A., Schenkman, Sergio, Tonelli, Renata R.   +4 more
core   +1 more source

Type 1 diabetes in India: Overall insights

Indian Journal of Endocrinology and Metabolism, 2015
Type 1 diabetes mellitus (T1DM) is also on increase like type 2 diabetes, even though not in the same proportion, but still with a trend of 3-5% increase/year. India has three new cases of T1DM/100,000 children of 0-14 years.
Ashok Kumar Das
doaj   +1 more source

Alterações microvasculares retinianas de aparecimento tardio e persistente após transplante de medula: seguimento de 3 anos [PDF]

, 2002
Purpose: To describe a case of persistent retinopathy after bone marrow transplantation in the absence of radiation therapy. Methods: Case Report.
Belfort, Rubens Junior, Farah, Michel Eid, Jorge, Rodrigo, Muccioli, Cristina, Pereira, Mauricio B.   +4 more
core   +2 more sources