Results 41 to 50 of about 15,168 (224)

Magneto-electric Nanoparticles to Enable Field-controlled High-Specificity Drug Delivery to Eradicate Ovarian Cancer Cells [PDF]

, 2013
The nanotechnology capable of high-specificity targeted delivery of anti-neoplastic drugs would be a significant breakthrough in Cancer in general and Ovarian Cancer in particular. We addressed this challenge through a new physical concept that exploited
Atluri, Venkata, Guduru, Rakesh, Khizroev, Sakhrat, Liang, Ping, Nair, Madhavan, Runowicz, Carolyn   +5 more
core   +1 more source

Index cases of intracranial aneurysms in autosomal dominant polycystic kidney disease: longitudinal experience from a single renal transplantation centre

ANZ Journal of Surgery, EarlyView.
Abstract Background The prevalence of intracranial aneurysms (ICAs) is higher in patients with autosomal dominant polycystic kidney disease (ADPKD) than in the general population. This extrarenal manifestation carries significant mortality and morbidity risks.
Joel Ern Zher Chan, Kate S. Olakkengil, Shantanu Bhattacharjya, Santosh Antony Olakkengil   +3 more
wiley   +1 more source

Network analysis of circular permutations in multidomain proteins reveals functional linkages for uncharacterized proteins. [PDF]

, 2014
Various studies have implicated different multidomain proteins in cancer. However, there has been little or no detailed study on the role of circular multidomain proteins in the general problem of cancer or on specific cancer types.
Adjeroh, Donald, Jiang, Bing-Hua, Jiang, Yue, Lin, Jie   +3 more
core   +3 more sources

Progression and topographic subtypes of Terrien marginal degeneration

Acta Ophthalmologica, EarlyView.
Abstract Purpose To report long‐term outcomes and to search for immunological and genetic risk factors in Terrien marginal degeneration (TMD). Methods Retrospective, in part prospective, hospital‐based longitudinal follow‐up study of 32 eyes of 16 Finnish patients from 2012 to 2023. Median follow‐up was 7.3 years (range, 0.3–15.2).
Minna Ruutila, Pauliina Repo, Annamari T. Immonen, Joni A. Turunen, Marja‐Liisa Lokki, A. Inkeri Lokki, Jukka Moilanen, Kari Krootila, Tero T. Kivelä   +8 more
wiley   +1 more source

Congenital aniridia: European COST action ANIRIDIA‐NET guidelines for diagnosis, management and care

Acta Ophthalmologica, EarlyView.
Abstract Congenital aniridia is a rare ocular disorder affecting the majority of eye structures and can be associated with systemic manifestations. The main visible phenotypic characteristic is the partial or complete absence of the iris; however, foveal hypoplasia is a more frequent and reliable clinical sign. Other ocular comorbidities are associated
Davide Romano, Vito Romano, Alejandra Daruich, Giulio Ferrari, Matthieu Robert, Francesco Semeraro, Neil Lagali, Dominique Bremond‐Gignac, the ANIRIDIA‐NET Clinical Guidelines Working Group, Miriam Barbany, Claus Cursiefen, Stefano Ferrari, Francisco Figueiredo, Christina Grupcheva, Jesper Hjortdal, Elke Kreps, Erlend Landsend, Laura Mauring, Hilde Pedersen, Nora Szentmáry, Bogumil Wowra, the Aniridia‐Europa and Geniris Working Group, Sophie Valleix, Juan Álvarez de Toledo, James Lauderdale, Tor Paaske Utheim, Paolo Rama   +26 more
wiley   +1 more source

Systemic Biologics Have Similar Safety to Vedolizumab in Inflammatory Bowel Disease Patients Following Liver Transplantation

Alimentary Pharmacology &Therapeutics, EarlyView.
In liver transplant recipients with coexistent inflammatory bowel disease, incidence of infectious events observed between those exposed to ‘gut‐specific’ and ‘systemic’ biologics were similar. Biologic choice should not be influenced by concerns regarding their co‐prescription with transplant immunosuppression.
Simone Chin, Danny Con, Patrick Hilley, Crispin Corte, Ken Liu, Adam Testro, Peter De Cruz, Matthew C. Choy, Ashish Srinivasan   +8 more
wiley   +1 more source

Patient survey in immune thrombocytopenia (ITP): Identifying unmet needs related to treatment and disease control in patients living in the United States

British Journal of Haematology, EarlyView.
Key aspects of this survey focused on treatment approach, controlling immune thrombocytopenia (ITP), health‐related quality of life (HRQOL) and patient support. Although most patients were receiving and adhering to ITP treatment, there was a lack of sustained efficacy, fuelling a need for better and more effective treatment options.
Nichola Cooper, Caroline Kruse, Sharon Deneen Morgan, Julie Laurent, Marleni Arvelo‐Saillant, Jean‐Pascal Roussy, Matias Cordoba, Imene Gouia, Lisa‐Anne Schmitt, Erin Reineke, Terry Gernsheimer   +10 more
wiley   +1 more source

Polyomanephropathie nach Nierentransplantation [PDF]

, 2018
Zusammenfassung: Die Polyomanephropathie (BKV-Nephropathie) ist eine bekannte Komplikation nach Organtransplantation. Sie tritt interessanterweise nur nach Nierentransplantation auf und führt zu einer Funktionsverschlechterung bis hin zum ...
Steiger, J.U.
core  

Identification and characterization of the binding sites of P-glycoprotein for multidrug resistance-related drugs and modulators [PDF]

, 2004
A major problem in cancer treatment is the development of resistance to multiple chemotherapeutic agents in tumor cells. A major mechanism of this multidrug resistance (MDR) is overexpression of the MDR1 product P-glycoprotein, known to bind to and ...
Safa, Ahmad R.
core   +1 more source

Increased ATP production and P‐glycoprotein activity underlie the marked changes in blood–brain barrier transport of drugs in a mouse model of amyotrophic lateral sclerosis

British Journal of Pharmacology, EarlyView.
Background and purpose Patients with amyotrophic lateral sclerosis (ALS) are prescribed many medications for symptomatic relief. However, how potential alterations to the blood–brain barrier (BBB) affect the brain exposure of drugs in ALS remains under‐investigated. Experimental approach We used high‐dimensional proteomic analysis, cellular metabolism,
Yijun Pan, Alanna G. Spiteri, Pranav Runwal, Jiaqi Sun, Dana S. Hutchinson, Yoshiteru Kagawa, Bradley J. Turner, Cheng Huang, Anup D. Shah, Ralf B. Schittenhelm, Joseph A. Nicolazzo   +10 more
wiley   +1 more source