Results 81 to 90 of about 3,781 (190)

Heterogeneity Landscape of Circulating Tumor Cells in Clinical Utility

Advanced Therapeutics, Volume 8, Issue 10, October 2025.
This study reports the heterogeneity spectrum of circulating tumor cells. The factors involved in the spectrum promote CTCs to overcome barriers in the metastatic cascade but impact the clinical outcome of cancer patients. In summary, the heterogeneities in association with CTCs ultimately reduce patient survival and facilitate increasing mortality of ...
Md Kowsar Alam, Lu Yanjun, Bee Luan Khoo, Tongxu Si, Heng Zou, Mengsu Yang   +5 more
wiley   +1 more source

血清CYFRA21-1、NSE联合检测对肺癌诊断的临床意义

Zhongguo shiyan zhenduanxue, 2008
目的探讨血清CYFRA21-1与NSE联合检测对肺癌的诊断价值。方法应用电化学发光免疫分析技术测定77例肺癌患者、22例肺部良性疾病患者和120例健康对照组血清CYFRA21-1、NSE的水平。结果肺癌患者血清CYFRA21-1、NSE水平明显高于肺部良性疾病组和健康对照组 ...
李兴华, 付艳, 赵云芳
doaj  

Prognostic Role of Serum Cytokeratin-19 Fragment (CYFRA 21-1) in Patients with Hepatocellular Carcinoma [PDF]

, 2020
Keratin 19 (K19) is a cancer stem cell marker expressed by a subpopulation of hepatocellular carcinoma (HCC), associated with tumor aggressiveness. We evaluated the prognostic value of serum K19 fragment (CYFRA 21-1), in comparison or in combination with
Abate, Maria Lorena, Bugianesi, Elisabetta, Carucci, Patrizia, Caviglia, Gian Paolo, Ciruolo, Michela, Gaia, Silvia, Olivero, Antonella, Ribaldone, Davide Giuseppe, Risso, Alessandra, Rolle, Emanuela, Rosso, Chiara, Saracco, Giorgio Maria, Tandoi, Francesco   +12 more
core   +1 more source

Prediction of Lung Cancer Metastasis Risk Based on Single‐Cell Metabolic Profiling of Circulating Tumor Cells

Advanced Science, Volume 12, Issue 39, October 20, 2025.
A self‐developed CTC sorting and capture platform enabled single‐cell metabolomics of patient/animal CTCs, revealing brain/bone metastasis‐specific metabolic signatures. A classification model developed from these signatures predicted lung cancer metastasis risk, outperforming traditional markers and total CTC counts (AUCs:89 brain = 0.74; bone = 0.92).
Yang Xu, Xuesen Hu, Yuan Yuan, Wenwen Liu, Jian Wang, Chunhui Yang, Xianzhe Shi, Wangshu Qin, Liliang Wen, Manqing Lin, Yinuo Jin, Wei Wang, Chunxiu Hu, Guowang Xu, Qi Wang   +14 more
wiley   +1 more source

Ocular Metastasis in Elderly Male Bladder Cancer Patients: Potential Risk Factors

American Journal of Men's Health, 2020
Bladder cancer is a common type of tumor among elderly male population; it causes intraocular metastasis (IOM). The study investigated the differences between elderly male bladder cancer patients with and without IOM, and identified risk factors for IOM.
Qian-Hui Xu, Qing Yuan, Yu-Qing Zhang, Biao Li, You-Lan Min, Qian-Min Ge, Rong-Bin Liang, Yi Shao   +7 more
doaj   +1 more source

细胞角蛋白19片段抗原21-1含量化学发光微粒子定量免疫检测方法的建立 [PDF]

, 2018
目的建立细胞角蛋白19片段抗原21-1(cytokeratin 19 fragment 21-1,CYFRA21-1,简称CY21-1)含量的化学发光微粒子免疫检测方法(chemiluminescent microparticle immunoassay,CMIA)。方法原核表达制备重组CY21-1(r CY21-1),用其免疫BALB/c小鼠后,收集小鼠脾脏细胞,常规杂交瘤技术与Sp2/0进行融合,制备CY21-1单抗。间接ELISA法筛选可稳定分泌CY21-1抗体的杂交瘤细胞,分别标记微性磁珠 ...
刘江武, 王英雪, 翁祖星, 葛胜祥, 郭小怡, 陈毅歆   +5 more
core   +1 more source

Loss of Skeletal Muscle Mass Is Associated With Reduced Cytotoxic T Cell Abundance and Poor Survival in Advanced Lung Cancer

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 5, October 2025.
ABSTRACT Background Body composition alterations such as skeletal muscle (SM) loss in cancer patients are associated with poor survival. In turn, immune cell‐driven pathways have been linked to muscle wasting. We aimed to investigate the relationship between body composition, tumour‐infiltrating lymphocytes and survival in patients with advanced lung ...
Xin Nie, Yan Sun, David P. J. van Dijk, Min Deng, Ralph Brecheisen, Zhaoqi Wang, Qingxin Xia, Steven M. W. Olde Damink, Sander S. Rensen   +8 more
wiley   +1 more source

评价CYFRA21-1、NSE和CEA对非小细胞肺癌的诊断价值

Zhongguo shiyan zhenduanxue, 2009
目的评价血清CYFRA21-1、NSE和CEA对非小细胞肺癌（NSCLC）辅助诊断的价值。方法检测178例NSCLC患者,98例良性肺疾病（BLD）患者和166例健康人血清中CYFRA21-1、NSE和CEA的浓度,CEA采用微粒子酶联免疫化学发光法,NSE和CYFRA21-1采用电化学发光法。结果三项血清肿瘤标志物（TM）在NSCLC中水平显著高于健康人和BLD患者。以健康人为对照组,特异性95%时,cut off值分别为CYFRA21-1 2.23μg/L,CEA 3.98μg/L,NSE20 ...
程黎明, 邓玲艳, 管青
doaj  

Plasma next generation sequencing and droplet digital-qPCR-based quantification of circulating cell-free RNA for noninvasive early detection of cancer [PDF]

, 2020
Early detection of cancer holds high promise for reducing cancer-related mortality. Detection of circulating tumor-specific nucleic acids holds promise, but sensitivity and specificity issues remain with current technology.
Hegedüs, B., Klein, Christoph A., Metzenmacher, M., Váraljai, R.   +3 more
core   +1 more source

Role of Serum Tumor Markers in Prognosis of Operable Non-small Cell Lung Cancer Patients

Zhongliu Fangzhi Yanjiu, 2018
Objective To evaluate the prognostic value of CEA, CA125, CA199, NSE, CYFRA21-1 and SCC-Ag as serum tumor markers on the diagnosis of operable non-small cell lung cancer(NSCLC) after radical operation.
LI Shaolei, MA Yuanyuan, XIONG Ying, ZHANG Shanyuan, HUANG Miao, YANG Yue   +5 more
doaj   +1 more source