Results 61 to 70 of about 21,238,241 (185)

Evaluation of serum CEA, CYFRA21-1 and CA125 for the early detection of colorectal cancer using longitudinal preclinical samples [PDF]

, 2015
Blood-borne biomarkers for early detection of colorectal cancer (CRC) could markedly increase screening uptake. The aim of this study was to evaluate serum carcinoembryonic antigen (CEA), CYFRA21-1 and CA125 for the early detection of CRC in an ...
J F Timms, I Jacobs, A Ryan, Jacobs, I, S Apostolidou, E-o Fourkala, Gunu, R, W Alderton, Timms, JF, Alderton, W, D S Thomas, R Gunu, U Menon, Thomas, DS, Fourkala, EO, Ryan, A, A Gentry-maharaj, Apostolidou, S, Gentry-Maharaj, A, Menon, U   +19 more
core   +1 more source

Acute Intestinal Obstruction Caused by Dual‐Component Metastasis From Combined Small Cell Lung Cancer: A Rare Case and Literature Review

Clinical Case Reports, Volume 14, Issue 3, March 2026.
ABSTRACT This case report describes a 75‐year‐old male patient who was admitted due to acute intestinal obstruction. The patient had a history of small cell lung cancer. Emergency surgery pathology confirmed the presence of primary composite small cell lung cancer with rare independent dual component metastasis: The colonic lesion was metastatic poorly
Wei Jiang, Xiaohui Zhou, Xizhang Zhu
wiley   +1 more source

DataSheet1_Highly sensitive detection of CYFRA21-1 with a SERS sensing platform based on the MBs enrichment strategy and antibody-DNA-mediated CHA amplification.docx

, 2023
Laryngeal carcinoma (LC) is the second most common malignant tumor of the head and neck. Due to its insidious nature, most patients have developed to the middle and late stages by the time they are diagnosed, missing the best treatment period.
Xiaotao Bao, Guang Li, Xiaoyan Liu (158152), Guang Li (109360), Shiyi Wang (6066389), Xiaoyan Liu, Shiyi Wang, Xiaotao Bao (16810215)   +7 more
core   +1 more source

Clinical Significance of Serum Cytokeratin 19 Fragment in the Prediction of Chemotherapy Efficacy and Prognosis in Patients with Advanced Non-small Cell Lung Cancer

Chinese Journal of Lung Cancer, 2010
Background and objective RECIST (Response Evaluation Criteria in Solid Tumors) criteria could not be used to detect viable tumor tissue and is not an accurate tool for evaluation of objective response (OR) in non-small cell lung cancer (NSCLC) patients ...
Chong'an XU, Jiali LIU, Lili XING, Shu LIU   +3 more
doaj  

An Extracellular Vesicle Protein‐Based Machine Learning Framework for Early Detection of Oesophageal Squamous Cell Carcinoma: A Multicentre, Prospective Study

Journal of Extracellular Vesicles, Volume 15, Issue 3, March 2026.
ABSTRACT Early detection of oesophageal squamous cell carcinoma (ESCC) is critical for improving survival, yet current screening is hampered by the lack of effective, non‐invasive methods. Here, we developed and prospectively validated an extracellular vesicle (EV) protein‐based blood test for the preclinical detection of ESCC.
Yu Wang, Shan Xing, Ya‐Xian Wu, Ning Xue, Pei‐Min Chen, Run‐Xian Jin, Yi‐Wei Xu, Ming‐Fang Ji, Yu‐Hui Peng, Yuan‐Tao Liu, Li‐Na Chen, Meng Wu, Zi‐Ying Jiang, Shang‐Hang Xie, Yi‐Ling Luo, Biao Zhang, Xin‐Yuan Ou, Qi Huang, Bo‐Yu Tian, Li Ling, Su‐Mei Cao, Wan‐Li Liu, Mu‐Sheng Zeng, Qian Zhong   +23 more
wiley   +1 more source

Clinical Significance of Serum Assay of CYFRA21-1 in Primary Lung Cancer.

Haigan, 1995
原発性肺癌における新しい腫瘍マーカーであるサイトケラチン19フラグメント (CYFRA21-1) の臨床的意義を検討するため原発性肺癌患者52例と他の肺疾患患者38例, 健常者22例について血清CYFRA21-1を測定し, 他の腫瘍マ-カー (CEA, SCC, NSE) と比較検討した.cut-off値を3.5ng/mlとすると原発性肺癌における陽性率は65%, 他の肺疾患における偽陽性率は8%であった.組織型別では, 扁平上皮癌で88.9%と最も高い陽性率を示し, 腺癌でも61.5%の陽性率を示した.免疫組織学的検討では扁平上皮癌において細胞質内で均一に強陽性に染色された.臨床病期別検討では, 1期50%, II期50%, IIIA期40%, IIIB期71%, IV期72 ...
Horiguchi, Takahiko, Tachikawa, Souichi, Munekata, Eiji, Takeuchi, Noriyuki, Hirabuki, Kouichi, Shiga, Mamoru, Sugiyama, Masahiro, Kondou, Rieko, Miyazaki, Junichi, Handa, Misuzu   +9 more
openaire   +2 more sources

Early Cancer Detection: What's Going on and What's Next

MedComm, Volume 7, Issue 3, March 2026.
Multicancer early detection (MCED) platforms have emerged as a promising strategy for the safe and effective early detection of multiple cancer types, with the potential to reduce metastatic burden and improve clinical outcomes, particularly for aggressive malignancies that lack effective population‐level screening.
Emma Di Carlo
wiley   +1 more source

Review of Existing Approaches and Potential Role of Pharmacometrics in the Interpretation of Prognostic Circulating Serum Biomarkers in Advanced NSCLC

Clinical and Translational Science, Volume 19, Issue 3, March 2026.
ABSTRACT Circulating serum biomarkers have prognostic value in patients with advanced NSCLC, yet their potential still remains underappreciated at present. This review discusses classical approaches of biomarker data analysis, highlighting gaps, and summarizing current methodologies to evaluate the relationship between serum biomarkers and clinical ...
Francis Williams Ojara, Yomna M. Nassar, Kimberly Geiger, Madele van Dyk, Stefan Holdenrieder, Markus Joerger, Charlotte Kloft   +6 more
wiley   +1 more source

Digital Biomarkers for Precision Early Detection of Lung Cancer: Integrating AI‐Driven Multi‐Omics Into Clinical Pathways

Cancer Medicine, Volume 15, Issue 2, February 2026.
ABSTRACT Background Lung cancer remains the leading cause of cancer‐related mortality worldwide, highlighting the urgent need for earlier detection within real‐world screening and patient management pathways. Recent advances in multi‐omics technologies have created new opportunities for identifying biomarkers associated with early‐stage lung cancer ...
Fan Bu, Zhi‐Qiang Ling
wiley   +1 more source

The important role of circulating CYFRA21-1 in metastasis diagnosis and prognostic value compared with carcinoembryonic antigen and neuron-specific enolase in lung cancer patients

, 2017
Background The roles of carcinoembryonic antigen (CEA), cytokeratin 19 fragments (CYFRA21-1) and neuron-specific enolase (NSE) in metastases occurrence and poor diagnosis in specific histological classifications of lung cancer need ...
Zhao, Shuang, Li, Yalun, Zhou, Ping, Lei Li (29537), Yanwen Wang (140487), Dan Liu (108669), Jing, Yuting, Yuting Jing (3714622), Li, Weimin, He Yu (3714625), Li Zhang (8200), Yihan Zhu (1333899), Zhang, Li, Zhu, Yihan, Yu, He, Zhixin Qiu (533367), Weimin Li (131040), Pu, Dan, Qiu, Zhixin, Liu, Dan, Dan Pu (3714616), Yanqi He (3714628), Wang, Yanwen, Yalun Li (3714619), He, Yanqi, Shuang Zhao (484057), Li, Lei, Ping Zhou (144535)   +27 more
core   +1 more source