Results 51 to 60 of about 3,930 (204)

Pleural Fluid Mesothelin as an Adjunct to the Diagnosis of Pleural Malignant Mesothelioma [PDF]

, 2014
Rationale:. The diagnosis of pleural malignant mesothelioma (MM) by effusion cytology may be difficult and is currently controversial. Effusion mesothelin levels are increased in patients with MM but the clinical role of this test is uncertain ...
Creaney, Jenette, Dick, Ian M., Musk, A. W(Bill), Olsen, Nola, Robinson, Bruce W., Segal, Amanda, Skates, Steven J.   +6 more
core   +2 more sources

A retrospective study for prognostic significance of type II diabetes mellitus and hemoglobin A1c levels in non-small cell lung cancer patients treated with pembrolizumab [PDF]

, 2022
Background: Diabetes mellitus (DM) is common and recognized as a risk factor for developing non-small cell lung cancer (NSCLC) while the prognostic evaluation is still controversial. As immunotherapy is widely used in clinical practice, its efficacy and
Abed, Afaf, Chang, Qing, Chu, Tianqing, Gelsomino, Francesco, Kim, Yeon Wook, Lei, Yuqiong, Li, Jiaqi, Qian, Jialin, Qiang, Huiping, Shen, Yinchen, Stella, Giulia Maria, Zhong, Runbo   +11 more
core   +2 more sources

Cytopathologic Features of Metastatic Malignant Mesothelioma With SMARCB1 (INI‐1) Deficient Diagnosed by Ultrasound‐Guided Fine‐Needle Aspiration: A Case Report

Diagnostic Cytopathology, Volume 54, Issue 4, Page E87-E92, April 2026.
ABSTRACT Malignant mesothelioma (MM) is a rare yet aggressive neoplasm that arises from mesothelial cells lining the thoracic and abdominal cavities, the pericardium, and the tunica testis. Characterized by rapid progression, high invasiveness, and a poor prognosis, MM poses significant clinical challenges. SMARCB1, also referred to as INI‐1, hSNF5, or
Jun Yang, Juandi Liu, Jing Jin, Deng Pan, Lei Shao   +4 more
wiley   +1 more source

Development of an enzyme-linked immunosorbent assay for the detection of human calretinin in plasma and serum of mesothelioma patients [PDF]

, 2010
Background Calretinin is one of the well-established immunohistochemical markers in the diagnostics of malignant mesothelioma (MM). Its utility as a diagnostic tool in human blood, however, is scarcely investigated.
Irina Raiko, Ingrid Sander, Daniel G Weber, Monika Raulf-Heimsoth, Adrian Gillissen, Jens Kollmeier, Arnaud Scherpereel, Thomas Brüning, Georg Johnen, L Greillier, A Scherpereel, J Creaney, EK Park, DG Weber, K Shiomi, JM Porcel, JH Rogers, B Schwaller, JC Gander, T Henzi, V Gotzos, C Doglioni, JE King, B Schwaller, CE Comin, NG Ordonez, GS Schierle, B Schwaller, L Winsky, L Zimmermann, B Schwaller, T Wiethege, A Larsen, DG Weber   +33 more
core   +1 more source

Case of Gastric Signet Ring Cell Carcinoma With Pulmonary Lymphangitic Carcinomatosis as the Initial Manifestation Diagnosed by Computed Tomography‐Guided Percutaneous Lung Biopsy

Respirology Case Reports, Volume 14, Issue 4, April 2026.
We report a case of gastric signet ring cell carcinoma with pulmonary lymphangitic carcinomatosis as the initial manifestation without gastrointestinal symptoms confirmed by CT‐guided percutaneous lung biopsy, with the aim of providing insights into diagnostic methods and differential diagnosis of similar cases.
Ping Li, Aimeinu Abulaizi, Asimuguli Shayilang, Xiaoxiao Lu   +3 more
wiley   +1 more source

Acute Intestinal Obstruction Caused by Dual‐Component Metastasis From Combined Small Cell Lung Cancer: A Rare Case and Literature Review

Clinical Case Reports, Volume 14, Issue 3, March 2026.
ABSTRACT This case report describes a 75‐year‐old male patient who was admitted due to acute intestinal obstruction. The patient had a history of small cell lung cancer. Emergency surgery pathology confirmed the presence of primary composite small cell lung cancer with rare independent dual component metastasis: The colonic lesion was metastatic poorly
Wei Jiang, Xiaohui Zhou, Xizhang Zhu
wiley   +1 more source

Clinical meaning of age-related expression of fecal cytokeratin 19 in colorectal malignancy [PDF]

, 2009
Background Colorectal cancer (CRC) is one of the leading causes of malignant death worldwide. Because young age of onset is often considered a poor prognostic factor for CRC, it is important to identify the poor outcomes of CRC in a younger population ...
Sun Hsiao-Lun, Lin Chih-Ming, Lee Chia-Long, Pan Shiann, Chen Shu-Hung, Chien Chih-Cheng, Yang Shung-Haur, Chang Chun-Chao, Huang Chi-Cheng, Wu Yih-Yiing, Yang Ruey-Neng, Huang Chi-Jung   +11 more
core   +2 more sources

An Extracellular Vesicle Protein‐Based Machine Learning Framework for Early Detection of Oesophageal Squamous Cell Carcinoma: A Multicentre, Prospective Study

Journal of Extracellular Vesicles, Volume 15, Issue 3, March 2026.
ABSTRACT Early detection of oesophageal squamous cell carcinoma (ESCC) is critical for improving survival, yet current screening is hampered by the lack of effective, non‐invasive methods. Here, we developed and prospectively validated an extracellular vesicle (EV) protein‐based blood test for the preclinical detection of ESCC.
Yu Wang, Shan Xing, Ya‐Xian Wu, Ning Xue, Pei‐Min Chen, Run‐Xian Jin, Yi‐Wei Xu, Ming‐Fang Ji, Yu‐Hui Peng, Yuan‐Tao Liu, Li‐Na Chen, Meng Wu, Zi‐Ying Jiang, Shang‐Hang Xie, Yi‐Ling Luo, Biao Zhang, Xin‐Yuan Ou, Qi Huang, Bo‐Yu Tian, Li Ling, Su‐Mei Cao, Wan‐Li Liu, Mu‐Sheng Zeng, Qian Zhong   +23 more
wiley   +1 more source

Clinical Significance of Serum Assay of CYFRA21-1 in Primary Lung Cancer.

Haigan, 1995
原発性肺癌における新しい腫瘍マーカーであるサイトケラチン19フラグメント (CYFRA21-1) の臨床的意義を検討するため原発性肺癌患者52例と他の肺疾患患者38例, 健常者22例について血清CYFRA21-1を測定し, 他の腫瘍マ-カー (CEA, SCC, NSE) と比較検討した.cut-off値を3.5ng/mlとすると原発性肺癌における陽性率は65%, 他の肺疾患における偽陽性率は8%であった.組織型別では, 扁平上皮癌で88.9%と最も高い陽性率を示し, 腺癌でも61.5%の陽性率を示した.免疫組織学的検討では扁平上皮癌において細胞質内で均一に強陽性に染色された.臨床病期別検討では, 1期50%, II期50%, IIIA期40%, IIIB期71%, IV期72 ...
Takahiko Horiguchi, Souichi Tachikawa, Eiji Munekata, Noriyuki Takeuchi, Kouichi Hirabuki, Mamoru Shiga, Masahiro Sugiyama, Rieko Kondou, Junichi Miyazaki, Misuzu Handa   +9 more
openaire   +2 more sources

Early Cancer Detection: What's Going on and What's Next

MedComm, Volume 7, Issue 3, March 2026.
Multicancer early detection (MCED) platforms have emerged as a promising strategy for the safe and effective early detection of multiple cancer types, with the potential to reduce metastatic burden and improve clinical outcomes, particularly for aggressive malignancies that lack effective population‐level screening.
Emma Di Carlo
wiley   +1 more source