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Establishment of a novel and highly permissive cell line for the efficient replication of cyprinid herpesvirus 2 (CyHV-2)

Veterinary Microbiology, 2015
Haematopoietic necrosis of gibel carp (Carassius auratus gibelio) is caused by cyprinid herpesvirus 2 (CyHV-2) and has caused huge economic losses in aquaculture worldwide. Currently the isolation and propagation of CyHV-2 in vitro is very difficult due to the lack of permissive cell lines.
Nan Jiang, Scott E Lapatra, Ling Jin
exaly   +3 more sources

Importation of CyHV-2-infected goldfish into the Netherlands

Diseases of Aquatic Organisms, 2017
Cyprinid herpesvirus 2 (CyHV-2) is known as the causative agent of herpesviral haematopoietic necrosis in goldfish Carassius auratus auratus. However, the virus has also been detected in Prussian carp C. gibelio and crucian carp C. carassius from European and Asian countries. To prevent spread of the causative virus to other areas, investigation of the
Ito, Takafumi   +2 more
openaire   +2 more sources

Diagnostic case report: Disease outbreak induced by CyHV-2 in goldfish in China

Aquaculture, 2020
Abstract A lethal disease of goldfish (Carassius auratus) afflicted ornamental fish farms in Beijing in 2018, causing severe financial losses. Morbidity and mortality are restricted to goldfish and occurred in spring and autumn, when water temperature was between 15 and 28 °C.
Na Jiang   +8 more
openaire   +1 more source

CyHV-2 ORF104 activates the p38 MAPK pathway

Fish & Shellfish Immunology, 2015
Cyprinid herpesvirus 2 (CyHV-2) is the pathogen responsible for herpesviral hematopoietic necrosis disease, which causes huge losses on aquaculture. So far the studies of CyHV-2 mainly focus on the identification and detection of this virus, but little is known about the role of specific CyHV-2 genes in the infection process.
Mi, Du   +7 more
openaire   +2 more sources

Akt inhibitors prevent CyHV-2 infection in vitro

Fish and Shellfish Immunology
Cyprinid herpesvirus 2 (CyHV-2) is a double-stranded DNA virus that infects goldfish (Carassius auratus) and crucian carp (C. carassius), resulting in substantial mortality rates and significant epidemiological implications. To gain deeper insights into CyHV-2-host interactions and identify potential therapeutic targets, quantitative proteomics ...
Liqun Lu
exaly   +3 more sources

Susceptibility of Japanese Cyprininae fish species to cyprinid herpesvirus 2 (CyHV-2)

Veterinary Microbiology, 2014
Cyprinid herpesvirus 2 (CyHV-2) is known as the causative agent of herpesviral haematopoietic necrosis (HVHN) of goldfish (Carassius auratus). Recently, the virus has also been detected from Prussian carp (C. gibelio) and crucian carp (C. carassius) from European and Asian countries.
Takafumi, Ito, Yukio, Maeno
openaire   +2 more sources

Recombinant baculovirus BacCarassius-D4ORFs has potential as a live vector vaccine against CyHV-2

Fish & Shellfish Immunology, 2019
Cyprinid herpesvirus II (CyHV-2) is highly contagious and pathogenic to Carassius auratus gibelio (gibel carp), causing enormous economic losses in aquaculture in Yancheng city, Jiangsu province, China; however, to date, there is no effective way to protect C. auratus gibelio from CyHV-2 infection.
Kun Li   +13 more
openaire   +2 more sources

Herpesviral haematopoietic necrosis virus (CyHV‐2) infection: case studies from commercial goldfish farms

Journal of Fish Diseases, 2009
AbstractHerpesviral haematopoietic necrosis is a disease of goldfish, Carassius auratus, caused by Cyprinid herpesvirus‐2 (CyHV‐2) infection. Quantitative PCR was carried out on tissue homogenates from healthy goldfish fingerlings, broodfish, eggs and fry directly sampled from commercial farms, from moribund fish submitted to our laboratory for disease
Goodwin, A.E.   +3 more
openaire   +3 more sources

Reactivation of cyprinid herpesvirus 2 (CyHV-2) in asymptomatic surviving goldfish Carassius auratus (L.) under immunosuppression

Fish & Shellfish Immunology, 2020
Cyprinid herpesvirus 2 (CyHV-2) is a highly contagious pathogen of goldfish (Carassius auratus) and Prussian carp (Carassius auratus gibelio) causing herpesviral hematopoietic necrosis. Our previous study revealed that CyHV-2 can persistently infect the kidney and spleen of goldfish that recovered from a primary infection.
Chang, Wei   +5 more
openaire   +2 more sources

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