Results 141 to 150 of about 5,995 (180)

Caffeine Intake and CYP1A2 Variants Associated With High Caffeine Intake Protect Non-Smokers From Hypertension

Human Molecular Genetics, 2012
The 15q24.1 locus, including CYP1A2, is associated with blood pressure (BP). The CYP1A2 rs762551 C allele is associated with lower CYP1A2 enzyme activity. CYP1A2 metabolizes caffeine and is induced by smoking. The association of caffeine consumption with
Marc Maillard, Idris Guessous, Clara Benzi Schmid   +2 more
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Effects of CYP1A2 Gene Polymorphisms on Antipyrine CYP1A2-Dependent Metabolism

Bulletin of Experimental Biology and Medicine, 2011
The distribution of two CYP1A2 gene polymorphisms, CYP1A2*F and CYP1A2*D, was studied in a group of 38 men. Antipyrine elimination test was carried out and urinary cotinine was measured. The contribution of these CYP1A2 gene polymorphisms, age, and tobacco smoking to accumulation of three main antipyrine metabolites in the urine was evaluated by ...
Yu I, Chernyak, V B, Itskovich, S I, Kolesnikov   +2 more
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Search for an association between the human CYP1A2 genotype and CYP1A2 metabolic phenotype

Pharmacogenetics and Genomics, 2006
The genotype responsible for more than 60-fold interindividual differences in human hepatic CYP1A2 constitutive expression is not understood. Resequencing the human CYP1A1_CYP1A2 locus (39.6 kb) in five major geographically isolated subgroups recently led to the identification of 85 single nucleotide polymorphisms (SNPs), 57 of which were double-hit ...
Zhengwen, Jiang, Nadine, Dragin, Lucia F, Jorge-Nebert, Martha V, Martin, F Peter, Guengerich, Eleni, Aklillu, Magnus, Ingelman-Sundberg, George J, Hammons, Beverly D, Lyn-Cook, Fred F, Kadlubar, Shannon N, Saldana, Michael, Sorter, Alexander A, Vinks, Nassr, Nassr, Oliver, von Richter, Li, Jin, Daniel W, Nebert   +16 more
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Induction of CYP1A2 by heavy coffee consumption is associated with the CYP1A2 −163C>A polymorphism

European Journal of Clinical Pharmacology, 2010
To investigate the association of CYP1A2 genetic polymorphisms with the inducing effect of heavy coffee consumption on CYP1A2 activity in Serbian and Swedish populations, and to determine the frequency of the CYP1A2 genetic polymorphisms in Serbs.Using PCR-RFLP and the tag-array minisequencing method, 126 Serbian healthy volunteers were genotyped for ...
Djordjevic, Natasa, Ghotbi R., Jankovic, Slobodan, Aklillu E.   +3 more
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An Evaluation of the Dose‐Dependent Inhibition of CYP1A2 by Rofecoxib Using Theophylline as a CYP1A2 Probe

The Journal of Clinical Pharmacology, 2003
This study was undertaken to determine whether rofecoxib can interfere with CYP1A2 activity in humans using theophylline as a probe substrate. Single oral doses of theophylline were administered to each of three panels of 12 healthy subjects receiving daily doses of rofecoxib for 7 days to examine the effect of rofecoxib administration on the ...
Kenneth, Bachmann, Donald, White, Luis, Jauregui, Jules I, Schwartz, Nancy G B, Agrawal, Ralph, Mazenko, Patrick J, Larson, Arturo G, Porras   +7 more
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Nonresponse to Clozapine and Ultrarapid CYP1A2 Activity

Journal of Clinical Psychopharmacology, 2004
Clozapine (CLO), an atypical antipsychotic, depends mainly on cytochrome P450 1A2 (CYP1A2) for its metabolic clearance. Four patients treated with CLO, who were smokers, were nonresponders and had low plasma levels while receiving usual doses.
Eap, C.B., Bender, S., Jaquenoud Sirot, E., Cucchia, G., Jonzier-Perey, M., Baumann, P., Allorge, D., Broly, F.   +7 more
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Metabolic Activation of Perampanel Mediated by CYP1A2

Chemical Research in Toxicology, 2022
Perampanel (PRP), a noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropanoic acid (AMPA) receptor antagonist with high selectivity, has been used as a new adjuvant for the treatment of fractional seizures with or without primary generalized tonic-clonic seizures and secondary generalized seizures in epilepsy patients over the age of 12.
Zifang Ding, Xu Wang, Ning Zhang, Chen Sun, Guode Zhao, Ying Peng, Jiang Zheng   +6 more
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Role of CYP1A2 in Hepatic Sequestration of Dioxin: Studies Using CYP1A2 Knock-Out Mice

Biochemical and Biophysical Research Communications, 1997
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD, dioxin), most potent of the polyhalogenated aromatic hydrocarbons, has been studied in a variety of genetically normal species. Transgenic mice lacking a cytochrome P450 1A2 gene were used to study the influence of the CYP1A2 gene on the hepatic sequestration and distribution of TCDD, 4-PeCDF (2,3,4,7,8 ...
J J, Diliberto, D, Burgin, L S, Birnbaum
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Role of CYP1A2 in the Hepatotoxicity of Acetaminophen: Investigations UsingCyp1a2Null Mice

Toxicology and Applied Pharmacology, 1998
Acetaminophen (APAP) is known to cause centrilobular hepatic necrosis under overdose conditions. This is thought to be mediated via the P450-generated reactive intermediate N-acetyl-p-benzoquinone imine (NAPQI). Initially, NAPQI is detoxified by conjugation with glutathione (GSH), but once GSH is depleted, NAPQI reacts more extensively with hepatic ...
R P, Tonge, E J, Kelly, S A, Bruschi, T, Kalhorn, D L, Eaton, D W, Nebert, S D, Nelson   +6 more
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2,3,7,8-Tetrachlorodibenzo-p-dioxin-Mediated Oxidative Stress in CYP1A2 Knockout (CYP1A2−/−) Mice

Biochemical and Biophysical Research Communications, 1999
The objective of the study was to compare alterations in indicators of oxidative stress following 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure in cytochrome P4501A2 (CYP1A2) knockout mice and their parental lineage strains (C57BL/6N and 129/Sv).
B P, Slezak, J J, Diliberto, L S, Birnbaum   +2 more
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