Results 131 to 140 of about 5,995 (180)
Phenotyping determination of cyp1a2 enzyme activity using caffeine in sheep [PDF]
Eurasian Journal of Veterinary SciencesAim: The aims of this study were to determine the validity of the plasma metabolic ratios (MR) to investigate the CYP1A2 activity in practice and to compare in vivo CYP1A2 enzyme activity using caffeine (CF) as a probe in Morkaraman (MK), Akkaraman (AK ...
Kamil Uney, Bünyamin Tras
doaj
Cancer Letters, 2005 Colorectal cancer (CRC) is believed to be related to the intake of processed meat and the formed heterocyclic aromatic amines (HCA) herein, which are metabolically activated by the enzymes cytochrome P4501A2 (CYP1A2) and N-acetyltransferase 2 (NAT2).
Moonen, H. +3 more
exaly +5 more sources
Role of CYP1A2 in caffeine pharmacokinetics and metabolism: studies using mice deficient in CYP1A2
Pharmacogenetics, 1996 We investigated the involvement of CYP1A2 in the pharmacokinetics and metabolism of caffeine using mice lacking its expression (CYP1A2 -/-). The half-life of caffeine elimination from blood was seven times longer in the CYP1A2 -/- than wild-type mice. The clearance was concomitantly eight times slower.
Buters, J.T.M. +5 more
openaire +4 more sources
CpG methylation of the mouse CYP1A2 promoter
Toxicology Letters, 2004 Cytochrome P450 1A2 (CYP1A2) is a xenobiotic metabolizing enzyme that is tissue-specifically regulated in the mammalian liver by arylhydrocarbon receptor (AhR)-dependent and -independent pathways. In this study, CpG methylation of the CYP1A2 promoter was analyzed in mouse tissues and liver-derived cells. Compared to lung and kidney, the CYP1A2 promoter
Bowhan, Jin +5 more
openaire +3 more sources
CYP1A2 genotype and rheumatoid arthritis in Koreans
Rheumatology International, 2009 Cytochrome P540 (CYP) 1A2 plays a role in the production of reactive oxygen species (ROS), which have been implicated in the development of rheumatoid arthritis (RA). The objective of this study was to investigate the association between a common polymorphism in the CYP1A2 gene with risk and severity of RA in a Korean population.
Cornelis, Marilyn C. +3 more
openaire +6 more sources
Clozapine Pharmacokinetics and Pharmacodynamics Studied With CYP1A2-Null Mice
Journal of Psychopharmacology, 2000 The aim of this study was to use the CYP1A2-null mouse to investigate the in-vivo contribution of CYP1A2 to clozapine pharmacokinetics and pharmacodynamics.
Katherine J. Aitchison +2 more
exaly +5 more sources