Results 151 to 160 of about 5,995 (180)
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Frequency of CYP1A2 Polymorphism in Beagle Dogs
Drug Metabolism Letters, 2007A single nucleotide polymorphism in the dog CYP1A2 gene causes these animals to be CYP1A2 deficient (i.e., lack functional CYP1A2 enzyme activity). Genotyping a colony of 79 dogs revealed 77% wild-type, 19% heterozygous, and 4% homozygous mutant animals. These genetic frequencies are significantly different from those previously reported and illustrate
Valerie J, Whiterock +4 more
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2015
This chapter discusses the genetics, metabolic actions, substrates, inducers, and inhibitors of cytochrome P450 ...
Danielle Roussel +2 more
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This chapter discusses the genetics, metabolic actions, substrates, inducers, and inhibitors of cytochrome P450 ...
Danielle Roussel +2 more
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Enoxacin is an inducer of CYP1A2 in rat liver
Biochemical Pharmacology, 1995The induction of cytochrome P450 by enoxacin, ciprofloxacin, and ofloxacin was investigated in female Wistar rats. Animals were treated orally with daily doses ranging from 10 to 400 mg enoxacin per kg body wt, 400 mg ciprofloxacin, or 400 mg ofloxacin per kg body wt for up to 7 days.
T G, Schulz +5 more
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Celecoxib is a CYP1A2 inhibitor in vitro but not in vivo
European Journal of Clinical Pharmacology, 2008We recently discovered that rofecoxib is a potent mechanism-based inhibitor of CYP1A2. The effect of the widely used cyclo-oxygenase-2 selective non-steroidal anti-inflammatory drug celecoxib on CYP1A2 activity has not been reported.The effect of celecoxib on CYP1A2 activity (phenacetin O-deethylation) was first studied in vitro using human liver ...
Marjo J, Karjalainen +2 more
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Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2005
The functional significance of genetic polymorphisms on tobacco smoke-induced CYP1A2 activity was examined. The influence of three polymorphisms of the cytochrome P450 1A2 gene (CYP1A2) (-3860 G-->A (allele *1C), -2467 T-->delT (allele *1D), -163C-->A (allele *1F)), located in the 5'-noncoding promoter region of the gene, on CYP1A2 activity (measured ...
PAVANELLO, Sofia +4 more
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The functional significance of genetic polymorphisms on tobacco smoke-induced CYP1A2 activity was examined. The influence of three polymorphisms of the cytochrome P450 1A2 gene (CYP1A2) (-3860 G-->A (allele *1C), -2467 T-->delT (allele *1D), -163C-->A (allele *1F)), located in the 5'-noncoding promoter region of the gene, on CYP1A2 activity (measured ...
PAVANELLO, Sofia +4 more
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Detailed modelling of caffeine metabolism and examination of the CYP1A2 gene
Pharmacogenetics, 1999The cytochrome P450 CYP1A2 is important in the metabolism of both drugs and procarcinogens such as heterocyclic amines. We aimed to clarify the existence of a phenotypic polymorphism and explore the molecular basis of such a polymorphism. Ninety-two non-smoking individuals underwent caffeine phenotyping. The distribution of the 1,7-dimethylxanthine + 1,
M R, Welfare +3 more
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Cytochrome P450 enzyme 1A2 (CYP1A2) plays a primary role in the biotransformation of numerous drugs. However, genetic variations could significantly affect therapeutic outcomes and predispose certain breeds to adverse drug reactions. Recently, a study revealed that CYP1A2 would be duplicated in some breeds of dogs.
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Olanzapine metabolism by CYP1A2/CYP2D6 and hyperglycaemia
Acta Neuropsychiatrica, 2004The relationship between olanzapine metabolism by CYP1A2/CYP2D6 and hyperglycaemia was investigated. The higher blood olanzapine concentration may be effected by the abnormal metabolism, but not always caused by hyperglycaemia.
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Inducibility of CYP1A2 by Omeprazole in Vivo Related to the Genetic Polymorphism of CYP1A2
British Journal of Clinical Pharmacology, 2002Yan Shu, Xiao-Ping Chen, Hong-Hao Zhou
exaly