Results 111 to 120 of about 5,995 (180)

Drug–Drug Interactions of Cenobamate With Medications: Dose‐Dependent Induction/Inhibition and Clinical Implications

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 11, November 2026.
ABSTRACT Cenobamate causes dose‐dependent cytochrome P450 (CYP)2B6 and CYP3A4 induction and CYP2C19 inhibition, raising concern over multi‐pathway drug–drug interactions (DDIs) in patients with epilepsy treated with cardiovascular co‐medications. We developed a physiologically based pharmacokinetic (PBPK) model for cenobamate and verified it using ...
Hiroyuki Ichida, Takaharu Nakao, Takanori Mori, Reina Makino, Marika Nakagawa, Kazuhiro Yoneda, Yoshiyuki Yamaura, Masanori Kuribayashi   +7 more
wiley   +1 more source

CYP1A2 and CYP2D6 gene polymorphisms in schizophrenic patients with neuroleptic drug-induced side effects

, 2016
Polymorphic variants of CYP1A2 and CYP2D6 genes of the cytochrome P450 system were studied in patients with schizophrenia with drug-induced motor disorders and hyperprolactinemia against the background of long-term neuroleptic therapy.
Semke, A. V., Voronina, E. N., Pozhidaev, I. V., Osmanova, D. Z., Ivanov, M. V., Fedorenko, O. Yu., Bokhan, N. A., Vyalova, N. M., Filipenko, M. L., Ivanova, S. A.   +9 more
core   +2 more sources

Antimicrobial Activity and In Silico ADME Properties of Tyrosol and Their Derivatives Compounds

ChemistrySelect, Volume 11, Issue 41, 3 November 2026.
In the present study, tyrosol derivatives were obtained with the aim of improving their antimicrobial activity. Derivative 2 exhibited good antimicrobial activity, with an MIC of 3.9 µg/mL. Derivative 3, meanwhile, showed moderate activity and is novel in the literature. ABSTRACT According to the World Health Organization (WHO), bacterial resistance is
Kathia Raquel Murillo Padilla, Rayanne Priscila Vieira da Conceição, José Edson de Sousa Siqueira, Luana Cardoso de Oliveira, Mayra Suelen da Silva Pinheiro, Patrícia Santana Barbosa Marinho, Andrey Moacir do Rosario Marinho   +6 more
wiley   +1 more source

Genetic Polymorphism of Cytochrome P450-1A2 (CYP1A2) and N-Acetyltransferase-2 (NAT2) Among Emiratis [PDF]

, 2017
Brief introduction: There are limited studies on CYP1A2 and NAT2 polymorphisms among Emiratis. Aims: This study aims to determine CYP1A2 and NAT2 alleles and genotypes and correlate these genotypes with caffeine metabolism phenotypes among Emiratis ...
Al-Ahmad, Mohammed Majed
core   +1 more source

Combating Campylobacter Resistance in Moroccan Poultry Using Essential Oil–Ciprofloxacin Combination

Veterinary Medicine and Science, Volume 12, Issue 6, November 2026.
With an estimated prevalence of 15.52% in Moroccan poultry, Campylobacter species pose a significant food safety concern. We investigated whether essential oils (EOs) could restore the efficacy of ciprofloxacin against multidrug‐resistant (MDR) strains.
Zineb Soubai, Nadia Ziyate, Rim Rais, Hamza Elhrech, Oumayma Aguerd, Abdelhakim Bouyahya, Taoufiq Benali, Mohamed Akhazzane, Hiba Mahir, Siham Fellahi, Waleed Al Abdulmonem, Imane El Houssni, Benaissa Attarassi, Nabila Auajjar   +13 more
wiley   +1 more source

Gene-environment interaction in Parkinson’s disease: Coffee, ADORA2A, and CYP1A2

, 2022
[[abstract]]Background and purpose: Drinking caffeinated coffee has been reported to provide protection against Parkinson's disease (PD). Caffeine is an adenosine A2A receptor (encoded by the gene ADORA2A) antagonist that increases dopaminergic ...
Ritz, Beate, Chuang, Yu-Hsuan, Lill, Christina M, Bertram, Lars, Sinsheimer, Janet S, Lassen, Christina F, Greene, Naomi, Lee, Pei-Chen, Hansen, Johnni   +8 more
core  

Liver Organoids: From Disease Modelling to Regenerative Medicine

Cell Proliferation, Volume 59, Issue 11, November 2026.
Liver organoids provide a versatile platform for disease modelling and drug discovery, leveraging stem cells and engineering techniques. They bridge research and clinical applications, offering significant potential for advancing precision medicine and regenerative therapies for liver diseases.
Tiepeng Wang, Xiaotian Qu, Jinhong Si, Junkang Meng, Ting Zhang, Shuliang Niu   +5 more
wiley   +1 more source

Effects of monocyte chemoattractant protein‐1, macrophage inflammatory protein‐1α, and interferon‐α2a on P450 enzymes in human hepatocytes in vitro

Pharmacology Research & Perspectives, 2019
Some immunomodulatory agents stimulate the release of cytokines capable of suppressing P450 enzymes and potentially affecting pharmacokinetics of coadministered medications. Cytokines released in response to an immunomodulator in the blood ex vivo can be
Maciej Czerwiński, Krystal Gilligan, Kevin Westland, Brian W. Ogilvie   +3 more
doaj   +1 more source

Phase 1 Evaluation of the Pharmacokinetics of Sevasemten (EDG‐5506) for Potential Food Effect and Drug–Drug Interaction With a CYP3A4 Moderate Inhibitor

Clinical and Translational Science, Volume 19, Issue 11, November 2026.
ABSTRACT Sevasemten (EDG‐5506) is an investigational, small molecule, in development for the treatment of Becker and Duchenne muscular dystrophy. In vitro data suggest sevasemten is a substrate for cytochrome P450 (CYP)3A4. Here, we investigate whether the pharmacokinetics (PK) of sevasemten are affected when co‐administered with a moderate CYP3A4 ...
Molly Madden, Roxana Donisa Dreghici, Jeffrey A. Silverman   +2 more
wiley   +1 more source

Influence of Intravenous Norepinephrine Administration on Melatonin Plasma Concentration in Awake and Anaesthetised Healthy Adult Volunteers

Journal of Pineal Research, Volume 78, Issue 6, November 2026.
ABSTRACT Melatonin (MEL) is an endogenous hormone that regulates circadian rhythm, immune function and oxidative stress responses. Norepinephrine (NE), an endogenous catecholamine, increases blood pressure through the sympathetic nervous system and is commonly administered intraoperatively or in the clinically ill patient for hemodynamic support ...
Marko MIrza Sahinovic, Ilonka Nadia de Keijzer, Manon Stern, Karin Marianne Vermeulen, Michel Maria Roger Fernand Struys, Anthony Ray Absalom, Johannes Pieter van den Berg, Jaap Jan Vos   +7 more
wiley   +1 more source