Results 101 to 110 of about 5,995 (180)

Gene-Environment Interaction in Parkinson's Disease: Coffee, ADORA2A, and CYP1A2 [PDF]

, 2016
Background and purposeDrinking caffeinated coffee has been reported to provide protection against Parkinson's disease (PD). Caffeine is an adenosine A2A receptor (encoded by the gene ADORA2A) antagonist that increases dopaminergic neurotransmission and ...
Lassen, Christina F, Chuang, Yu-Hsuan, Lill, Christina M, Hansen, Johnni, Bertram, Lars, Sinsheimer, Janet S, Lee, Pei-Chen, Greene, Naomi, Ritz, Beate   +8 more
core   +1 more source

Practical Considerations for the Design, Conduct, and Reporting of Clinical Pharmacokinetic Drug–Drug Interaction Studies in Drug Development

The Journal of Clinical Pharmacology, Volume 66, Issue 11, November 2026.
Abstract Clinical pharmacokinetic drug–drug interaction (PK‐DDI) studies are frequently required in drug development when metabolizing enzymes and transporters determine pharmacokinetics. Drugs can be victims, perpetrators, or victims and perpetrators, of PK‐DDIs, so the clinical consequences of these interactions, particularly the risks of severe ...
Thomas M. Polasek, John O. Miners
wiley   +1 more source

Curcumin in the Treatment of Various Diseases: Mechanism of Action, Bioavailability, Therapeutic Effects, and Current Clinical Trials

MedComm, Volume 7, Issue 11, November 2026.
Curcumin, a naturally occurring polyphenol, exhibits significant anti‐inflammatory and antioxidant capabilities. This review elucidates the specific molecular mechanisms by which curcumin exerts therapeutic effects on various diseases, including neurological disorders, cardiovascular diseases, cancers, inflammatory disorders, and autoimmune diseases ...
Lin Wang, Qifei Pan, Wenjuan Long, Xinyao Li, Jianqin Mao, Sitong Zhou, Zihui Wang, Xuelian Zou, Yuqing She, Mingqin Shi, Yang Zhou, Jiarong Du, Zhongyang Hu, Xiaoman Lv, Yishu Chen, Dongdong Qin   +15 more
wiley   +1 more source

Prediction of Pharmacokinetic Drug–Drug Interactions Involving Anlotinib as a Victim by Using Physiologically Based Pharmacokinetic Modeling

Drug Design, Development and Therapy
Fengjiao Bu,1,2,* Yong-Soon Cho,3,4,* Qingfeng He,1 Xiaowen Wang,1 Saurav Howlader,3,4 Dong-Hyun Kim,3,4 Mingshe Zhu,5 Jae Gook Shin,3,4 Xiaoqiang Xiang1,6 1Department of Clinical Pharmacy and Pharmacy Administration, School of Pharmacy, Fudan ...
Bu F, Cho YS, He Q, Wang X, Howlader S, Kim DH, Zhu M, Shin JG, Xiang X   +8 more
doaj  

Novel Carbazole–Acylthiourea Derivatives: Synthesis, Antimicrobial, Antioxidant, Hemocompatibility, Cytotoxicity, and ADME‐Tox Profiling

ChemistryOpen, Volume 15, Issue 11, November 2026.
We synthesized four novel carprofen‐derived carbazole–acylthiourea propanamides with selective antimicrobial activity against Staphylococcus aureus, Enterococcus faecalis, and Candida albicans. Compound 1a provides combined antioxidant and antihemolytic protection.
Carmen Limban, Ioana Cristina Marinaş, Mariana Carmen Chifiriuc, Miron Teodor Căproiu, Florea Dumitraşcu, Erzsébet‐Eleonóra Kapronczai, Irina Zarafu, Diana Camelia Nuţă, Petre Ioniţă, Speranţa Avram, Cătălina Mareş, Andra Maria Păun, Bogdan Mihai Cristea, Carmellina Daniela Bădiceanu, Ilinca Margareta Vlad, Maria Coandă, Delia Laura Popescu, Coralia Bleotu   +17 more
wiley   +1 more source

In Vitro and In Vivo Effects of Resveratrol on Rat Hepatic CYP1A2

Pharmaceuticals
Background/Objectives: Although several studies have been reported on the modulation of Cytochrome P450 by resveratrol, inconsistencies in the results obtained require further investigation. Here, we report the results of in vivo and in vitro experiments
Sandra Luz Hernández-Ojeda, Raquel López-Arellano, Carla O. Contreras-Ochoa, Daniel Hernandez-Patlan, Rafael Camacho-Carranza, Antonio Romo-Mancillas, Giovanny Aguilera-Durán, Carlos A. Hernández-Gallardo, Ricardo I. Cárdenas-Ávila, Tzipe S. Govezensky, Elvia A. Morales-Hipólito, Javier J. Espinosa-Aguirre   +11 more
doaj   +1 more source

Genetic susceptibility to Tardive Dyskinesia in chronic schizophrenia subjects: I. Association of CYP1A2 gene polymorphism

, 2005
Understanding the pharmacogenetic basis of developing iatrogenic disorders such as Tardive Dyskinesia (TD) has significant clinical implications. CYP1A2, an inducible gene of the cytochrome P450 family of genes, has been suggested to contribute to the ...
Shriharsh, V., Lerer, B., Tiwari, A. K., Rao, A. R., Bhatia, T., Deshpande, S. N., Mukit, S. R., Nimagaonkar, V. L., Thelma, B. K.   +8 more
core   +1 more source

Clozapine‐Associated Neutropenia With COVID‐19 Infection and the Role of Filgrastim

Progress in Neurology and Psychiatry, Volume 30, Issue 4, November 2026.
ABSTRACT Clozapine is the gold standard, evidence‐based treatment of choice for treatment‐resistant schizophrenia. However, clozapine can induce serious, life‐threatening adverse effects, including neutropenia and agranulocytosis. There is accumulating evidence to suggest that rechallenging with clozapine should be considered in most patients with ...
Devender Singh Yadav
wiley   +1 more source

CYP1A2 genotype-dependent effects of smoking on mirtazapine serum concentrations

Introduction: Psychopharmacotherapy with mirtazapine is commonplace. Lower serum concentrations of mirtazapine were reported in smokers due to CYP1A2 induction.
Unterecker, S., Domschke, Katharina, Stonawski, S., Weber, Heike, Menke, A., Erhardt-Lehmann, A., Walther, Sebastian, Unterecker, Stefan, Menke, Andreas, Weber, H., Scherf-Clavel, M., Kluepfel, C., Hommers, Leif, Hommers, L., Kittel-Schneider, S., Walther, S., Erhardt-Lehmann, Angelika, Weiß, Carolin, Stonawski, Saskia, Domschke, K., Deckert, J., Klüpfel, Catherina, Weiss, C., Deckert, Jürgen, Scherf-Clavel, Maike, Kittel-Schneider, Sarah   +25 more
core   +1 more source

Interaction between CYP1A2-T2467DELT polymorphism and smoking in adenocarcinoma and squamous cell carcinoma of the lung

, 2007
This study aimed to identify new genetic characteristics contributing to individual susceptibility to smoke-induced lung cancer. Despite functional evidence of a possible role of cytochrome P450 1A2 (CYP1A2) in lung cancer susceptibility, no studies have
CLONFERO, ERMINIO, BEN FRAJ R, Pavanello S., PAVANELLO, SOFIA, Pulliero A., El Aziz Hayouni A., Mastrangelo G., Ben Fraj R., MASTRANGELO, GIUSEPPE, B'CHIR F, Clonfero E., B'chir F., SAGUEM S, Saguem S., PULLIERO A, EL HAZIZ HAYOUNI A, Fatma B’chir, Radhia Ben Fraj, Erminio Clonfero, Giuseppe Mastrangelo, Abed El Aziz Hayouni, Sofia Pavanello, Alessandra Pulliero, Saâd Saguem   +23 more
core   +1 more source