Results 81 to 90 of about 5,995 (180)

Inhibition of baicalin on metabolism of phenacetin, a probe of CYP1A2, in human liver microsomes and in rats.

PLoS ONE, 2014
Baicalin has been used as mainly bioactive constituent of about 100 kinds of traditional Chinese medicines in Chinese pharmacopoeia. The effect of baicalin on cytochrome P450 should be paid more attention because baicalin was used widely. The aim of this
Na Gao, Bing Qi, Fang-jun Liu, Yan Fang, Jun Zhou, Lin-jing Jia, Hai-ling Qiao   +6 more
doaj   +1 more source

Integrating Pharmacogenomic Testing Within the 4Ms Framework for Management of Behavioral Symptoms in Advanced Vascular Dementia: A Case Study

Journal of the American Geriatrics Society, EarlyView.
Pharmacogenomic‐guided managment of behavioral symptoms within the 4Ms framework.
Gianna Franco, Collins Njoku, Mary L. Wagner, Fred A. Kobylarz   +3 more
wiley   +1 more source

CYP1A2 – alelos comunes e inductores

, 2019
CYP1A2 introduce la característica de actividad enzimática variable. Ciertas sustancias (p. ej., tabaco, medicamentos, ciertos alimentos) pueden incrementar la actividad enzimática.
Mercedes Guaia Memita Guaia
core   +1 more source

Industry Perspective on Current Guidelines, Challenges, and Future Directions for ADME Characterization of Payloads for Antibody‐Drug Conjugates

Pharmacology Research &Perspectives, Volume 14, Issue 6, December 2026.
ABSTRACT A total of 15 antibody‐drug conjugates (ADC)s have been approved by USFDA till December 2025 with the use of nine cytotoxic payload molecules. Small molecule payloads can undergo enzymatic or nonenzymatic biotransformation, distribution, protein or red blood cell binding, transporter mediated disposition and urinary and/or biliary‐fecal ...
Vijay More, Kiran Deshpande, Chaitali Passey, Gaurav Bajaj, Jeff Barrett, Manish Gupta   +5 more
wiley   +1 more source

POLYMORPHISMS OF THE CYP1A1, CYP1A2, CYP19, AND SULT1A1 GENES ARE NOT ASSOCIATED WITH INFERTILITY IN WOMEN WITH GENITAL ENDOMETRIOSIS

Фундаментальная и клиническая медицина, 2018
Aim. To estimate whether CYP1A1, CYP1A2, CYP19, SULT1A1 gene polymorphisms are associated with genital endometriosis in infertile women. Materials and Methods.
LARISA N. Danilova, VITALIY O. Chervov, NATALIA V. Artymuk, LYUDMILA A. Gordeeva   +3 more
doaj  

Evaluation of the relationship between cytochrome P450 (CYP) 1A2 gene copy number variation and CYP1A2 protein content and enzyme activity in canine liver

Frontiers in Veterinary Science
Cytochrome P450 (CYP) 1A2 plays a key role in the metabolism of various drugs in dogs. However, the impact of genetic variation on differences in CYP1A2 metabolism among dogs remains unclear.
Francisco Gonzales Zamora, Hannah Bigelow, Hong Yang, Tania Perez Jimenez   +3 more
doaj   +1 more source

丹皮酚在人肝微粒体中主要经CYP1A2代谢

, 2009
Paeonol, the primary active component of a traditional Chinese medicine Moutan Cortex, has a wide range of pharmacological activities. As compared to the extensive research of the pharmacological activities of paeonol, few studies have dealed with its ...
杨凌, Yang, 刘慧鑫, L
core  

Quinoxaline–Triazole Hybrids: Exploring the Impact of Substituent Architecture on Cytotoxic Potency and Receptor Interaction

Chemistry &Biodiversity, Volume 23, Issue 11, November 2026.
A series of title compounds was synthesized, with 6e and 6k exhibiting the lowest IC50 values against MCF‐7, HeLa, and HepG2 cancer cell lines. Molecular docking and dynamics revealed strong binding to the adenosine A1 receptor (ΔG = –9.02 and –9.24 kcal/mol).
Bangar Reddy Vancha, Mandapalli Sreeshitha, Shaik Farheen Banu, Kamala Prasad Vasikarla, Satyanarayana Swamy Vyshnava, Mukhriddin Makhkamov, Parthiban Marimuthu, Jamoliddin Razzokov, Aminul Islam, Peddiahgari Vasu Govardhana Reddy   +9 more
wiley   +1 more source

DEVELOPMENT AND VALIDATION OF SIMULTANEOUS ASSAY OF SUBSTRATES-MARKERS OF MAIN CYTOCHROME P450 ISOFORMS AND THEIR METABOLITES USING HPLC-MS/MS

Разработка и регистрация лекарственных средств, 2019
Simultaneous quantification method of assaying main CYP isoforms substrates-markers and their metabolites in urine using HPLC-MS/MS was developed to determine activity of following isoforms: caffeine/paraxanthine for CYP1A2, losartane/E-3174 for CYP2C9 ...
E. A. Egorenkov, V. V. Smirnov
doaj  

Development of Novel Furan–Chalcone Derivatives as Targeting Bacterial DNA Gyrase and Topoisomerase IV: Design, Synthesis, and In Silico Studies

Chemistry &Biodiversity, Volume 23, Issue 11, November 2026.
Furan–chalcone derivatives (Na1–Na8) were successfully designed, synthesized, and biologically evaluated using integrated experimental and computational approaches. ABSTRACT A series of novel furan–chalcone derivatives (Na1–Na8) were synthesized and evaluated for their antimicrobial, antioxidant, DNA gyrase inhibitory, and computational properties ...
Nagaraj N Durgadasheemi, Vishal CS
wiley   +1 more source