Results 71 to 80 of about 5,995 (180)

Изоформа CYP1A2, как составная часть суперсемейства цитохрома P450 [PDF]

, 2014
The role of cytochrome P450 isoforms CYP1A2 and in the metabolism of caffeine is described. Caffeine pharmacokinetics data in humans and laboratory animals are presented.
Y. G. Novickaya, А. О. Виглинская, V. P. Zherdev, A. A. Litvin, Владимир Павлович Жердев, A. O. Viglinskaya, А. А. Литвин, Я. Г. Новицкая   +7 more
core  

Factors Associated With Long‐Term Survivors With Epidermal Growth Factor Receptor Positive Non‐Small Cell Lung Cancer Treated With First or Second‐Generation Tyrosine Kinase Inhibitors: A Canadian Multi‐Center Cohort

Asia-Pacific Journal of Clinical Oncology, EarlyView.
In a multi‐center Canadian cohort of 577 patients with advanced epidermal growth factor receptor‐mutated non‐small cell lung cancer treated with first/second‐generation TKIs, Asian ancestry and female sex predicted longer survival, while the L858R mutation predicted shorter survival.
Heather Halperin, Amanda J. W. Gibson, Ali Hussein, Mike Sung, Pascale Tomasini, Michelle Dean, Jennifer H. Law, Cheryl Ho, Vishal Navani, Natasha B. Leighl, Desiree Hao   +10 more
wiley   +1 more source

CpG site degeneration triggered by the loss of functional constraint created a highly polymorphic macaque drug-metabolizing gene, CYP1A2

BMC Evolutionary Biology, 2011
Background Elucidating the pattern of evolutionary changes in drug-metabolizing genes is an important subject not only for evolutionary but for biomedical research.
Osada Naoki, Uno Yasuhiro
doaj   +1 more source

Differential Roles for IL‐4Rα and IL‐13Rα1 in Immune Cell Infiltration and Epithelial Remodeling in Experimental Eosinophilic Gastritis

Allergy, EarlyView.
This study described the development of an experimental model for eosinophilic gastritis (EoG). Experimental EoG recapitulates histopathological features of human disease. including foveolar elongation, fibrosis, eosinophilia, mastocytosis and shared transcriptional programs.
Anish Dsilva, Shraddha Sharma, Shireen Barakey, Ariel Wagner, Alice Keisar, Tali Bar‐on, Michal Itan, Ariel Munitz   +7 more
wiley   +1 more source

Polimorfismos genéticos CYP1A2*1C, CYP1A2*1D en pacientes con esquizofrenia del Hospital del Salvador de Valparaíso

, 2017
Los polimorfismos genéticos para la isoenzima CYP1A2 (alelos CYP2A1*1C, CYP2A1*1F y CYP2A1*1D) tienen demostrada implicancia clínica sobre la farmacocinética de algunos fármacos, incluidos algunos de uso habitual en psiquiatría. Por esto, cobra
Ayala Parada, Nicolás
core   +1 more source

Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption.

PLoS Genetics, 2011
We report the first genome-wide association study of habitual caffeine intake. We included 47,341 individuals of European descent based on five population-based studies within the United States.
Marilyn C Cornelis, Keri L Monda, Kai Yu, Nina Paynter, Elizabeth M Azzato, Siiri N Bennett, Sonja I Berndt, Eric Boerwinkle, Stephen Chanock, Nilanjan Chatterjee, David Couper, Gary Curhan, Gerardo Heiss, Frank B Hu, David J Hunter, Kevin Jacobs, Majken K Jensen, Peter Kraft, Maria Teresa Landi, Jennifer A Nettleton, Mark P Purdue, Preetha Rajaraman, Eric B Rimm, Lynda M Rose, Nathaniel Rothman, Debra Silverman, Rachael Stolzenberg-Solomon, Amy Subar, Meredith Yeager, Daniel I Chasman, Rob M van Dam, Neil E Caporaso   +31 more
doaj   +1 more source

Biomarker Discovery for Cytochrome P450 1A2 Activity Assessment in Rats, Based on Metabolomics

Metabolites, 2019
Cytochrome P450 1A2 (CYP1A2) is one of the major CYP450 enzymes (CYPs) in the liver, and participates in the biotransformation of various xenobiotics and endogenous signaling molecules.
Xiao Pu, Yiqiao Gao, Ruiting Li, Wei Li, Yuan Tian, Zunjian Zhang, Fengguo Xu   +6 more
doaj   +1 more source

Frequencies of CYP1A2 Single Nucleotide Polymorphism in Indonesian and Its Effect on Blood Pressure [PDF]

, 2018
BACKGROUND:  The association between caffeine with blood pressure (BP) still remains controversial. Caffeine is mainly metabolized by cytochrome-P450 (CYP)1A2 enzyme.
Santoso, Anwar, Sandra, Ferry, Andi Wijaya, Wijaya, Andi, Sugiono, Erizal, Ferry Sandra, Yusuf, Irawan, Anwar Santoso, Ilham Jaya Patellongi, Patellongi, Ilham Jaya, Erizal Sugiono, Irawan Yusuf   +11 more
core   +1 more source

Methyl 4‐O‐Demethylbarbatate Destabilises HIF‐1α and Enhances Temozolomide Sensitivity in Glioma Cells

Cell Proliferation, EarlyView.
The lichen‐derived metabolite methyl 4‐O‐demethylbarbatate (Me‐4‐O‐DBA) suppresses glioma stemness, motility, and metabolic plasticity through inhibition of HIF‐1α signaling and synergistically enhances temozolomide activity, highlighting a potential strategy to target stemness‐driven therapeutic resistance in glioma.
Rui Zhou, Mücahit Varlı, Rundong Liu, Jieun Yu, Hyung‐Ho Ha, Jae‐Seoun Hur, Sang Kyum Kim, Hahyun Park, Hangun Kim   +8 more
wiley   +1 more source

EVALUATING THE EFFECT OF THE CYP1A2 rs762551 GENE POLYMORPHISM ON ARROWHEAD AGILITY DRILL TEST PERFORMANCE IN PHYSICALLY ACTIVE YOUNG MEN

Spormetre Beden Eğitimi ve Spor Bilimleri Dergisi
The purpose of this study is to determine the different results and genotype distributions associated with the effect of CYP1A2 rs762551 gene polymorphisms on the development rates of arrowhead agility drill test performance after six weeks of training ...
Selin Yıldırım Tuncer, Mesut Cerit, Murat Anilir, Tolga Polat, Esra Yildiz   +4 more
doaj   +1 more source