Results 61 to 70 of about 5,995 (180)

Metabolism of ropinirole is mediated by several canine CYP enzymes

Veterinary Medicine and Science, 2023
Background Ropinirole has been shown to provoke vomiting in dogs by activating the dopamine D2‐like receptors in the chemoreceptor trigger zone. In humans, ropinirole is metabolized primarily by CYP1A2.
Tuomas Tervahauta, Päivi Uutela, Mikko Koskinen   +2 more
doaj   +1 more source

Association between CYP1A2 polymorphisms and clozapine-induced adverse reactions in patients with schizophrenia

, 2012
We investigated the relationships between common polymorphisms in CYP1A2 (CYP1A2*1C and *1F), CYP1A2-mRNA levels in circulating lymphocytes and clozapine(CLZ)-induced adverse drug reactions (ADRs) in 34 patients. Patients with ADRs had a higher frequency
MARINO, FRANCA, FERRARI, MARCO, POLONI, NICOLA, Bolla, Emilio, BORTOLASO, PAOLA, COSENTINO, MARCO, CALLEGARI, CAMILLA, VENDER, SIMONE, LECCHINI, SERGIO   +8 more
core   +1 more source

Current status and future perspectives of platelet function‐guided precision antiplatelet therapy for patients with cerebral infarction

Neuroprotection, EarlyView.
Antiplatelet agents target the cyclooxygenase‐1 (COX‐1)/thromboxane A2 (TXA2) and adenosine diphosphate (ADP)‐P2Y12 (cytochrome P450 2C19 [CYP2C19]‐metabolized) platelet activation pathways, resulting in either drug resistance or over‐inhibition. The individualized therapeutic window balances ischemic risk (triggered by high on‐treatment platelet ...
Guoliang Zhu, Xiaoling Chen, Xinyi Huang, Quandan Tan, Qing Cao, Yali Yang, Yapeng Lin, Jie Yang   +7 more
wiley   +1 more source

Impact of smoking, smoking cessation, and genetic polymorphisms on CYP1A2 activity and inducibility

, 2011
Cytochrome P4501A2 (CYP1A2) is involved in the metabolism of several drugs and is induced by smoking. We aimed to determine the interindividual change in CYP1A2 activity after smoking cessation and to relate it to CYP1A2 genetic polymorphisms.
M Puhl, Puhl, M, Cornuz, J, Oneda, Beatrice; https://orcid.org/, B Oneda, J Cornuz, C B Eap, Dobrinas, M, Eap, C B, Kohler Serra, M, M Dobrinas, M Kohler Serra, Eap CB, Kohler Serra, M., Oneda, B., Eap, C.B., Puhl, M., Dobrinas, M., Cornuz, J., Dobrinas M, Kohler Serra M, Puhl M, Cornuz J, Oneda B   +23 more
core   +1 more source

Bioactive Natural Products in Cardiovascular Disease: Focus on Thrombotic Events

Phytotherapy Research, EarlyView.
An overview of the role of natural products (NP) in cardiovascular disease prevention, highlighting key mechanisms of action: including antiplatelet, antithrombotic, anti‐inflammatory, and antioxidant effects. Additionally, it illustrates the integration of diet–drug interactions, nutritional epigenetics, and the role of artificial intelligence in ...
Maria Nektaria Magkoulia, Despoina Pantazi   +1 more
wiley   +1 more source

Heteromeric Complex Formation between CYP2E1 and CYP1A2:  Evidence for the Involvement of Electrostatic Interactions^†

, 2016
Mixed reconstituted systems containing CYP2B4, CYP1A2, and NADPH−cytochrome P450 reductase were previously shown to exhibit a dramatic inhibition of 7-pentoxyresorufin O-dealkylation (PROD) when compared to simple reconstituted systems containing ...
Wayne L. Backes (2398465), Dongmei Cheng (384931), Rusty W. Kelley (2514142)   +2 more
core   +2 more sources

Association between CYP1A2 and CYP1B1 polymorphisms and colorectal cancer risk: a meta-analysis. [PDF]

PLoS ONE, 2014
BACKGROUND: The previous published data on the association between CYP1A2*F (rs762551), CYP1B1 Leu432Val (rs1056836), Asn453Ser (rs180040), and Arg48Gly (rs10012) polymorphisms and colorectal cancer risk remained controversial.
Xiao-Feng He, Jie Wei, Zhi-Zhong Liu, Jian-Jun Xie, Wei Wang, Ya-Ping Du, Yu Chen, Hui-Qiang Si, Qing Liu, Li-Xia Wu, Wu Wei   +10 more
doaj   +1 more source

Glutathione S-transferase M1 and T1, CYP1A2-2467T/delT polymorphisms and non small-cell lung cancer risk in Tunisian sample [PDF]

, 2012
The present study investigated the impact of metabolic gene polymorphisms in modulating lung cancer risk susceptibility. Gene polymorphisms encoding Cytochrome 1A2 (CYP1A2) and Glutathione-S-transferases (GSTT1 and GSTM1) are involved in the ...
B’chir Fatma, Aida, T, Saguem, S, Taieb Aida, J. Arnaud Maurice, Maurice, JA, Fatma, B, Saad Saguem   +7 more
core   +1 more source

Pharmacokinetic and Pharmacodynamic Interactions Between Anti‐Asthma Drugs and Medicinal Plants: A Comprehensive Review

Phytotherapy Research, EarlyView.
ABSTRACT Asthma affects 260–300 million people worldwide. About 20%–35% of patients use medicinal plants with their asthma medication, often without telling their clinicians. Disclosure rates are low; up to 42% of asthma outpatients use herbal products, with no records in their charts.
Emine Kocyigit, Aylin Bülbül, Betul Kocaadam‐Bozkurt, Osman Bozkurt, Duygu Ağagündüz, Raffaele Capasso   +5 more
wiley   +1 more source

Multi‐Target Pharmacological Mechanisms of Salvia miltiorrhiza Bunge in Metabolic Syndrome and Cardiovascular Diseases: A Comprehensive Review Based on the Theory of “Same Treatment for Different Diseases”

Phytotherapy Research, EarlyView.
Salvia miltiorrhiza Bunge in metabolic syndrome and cardiovascular diseases: multi‐target actions on shared signaling pathways. ABSTRACT Metabolic syndrome (MetS) represents a clinical disorder characterized by the clustering of conditions including obesity, elevated blood sugar levels, and high lipid levels, which are intricately linked to the onset ...
Zhiyi Jia, Kaiyi Wu, Jiaying Qi, Nana Huang, Yusheng Liu, Xiumei Gao, Rong Sun   +6 more
wiley   +1 more source