Results 91 to 100 of about 5,995 (180)

Integrated assessment of rifampicin‐mediated induction of transporters and drug‐metabolizing enzymes in a long‐term human liver tissue chip system

Clinical Pharmacology &Therapeutics, Volume 120, Issue 5, Page 1368-1378, November 2026.
Rifampicin is a prototypical clinical inducer used in drug–drug interaction (DDI) studies. However, the clinical relevance and predictability of rifampicin‐mediated hepatic transporter induction remain poorly defined. Conventional hepatocyte culture models fail to capture clinically relevant regulation of transporters and drug‐metabolizing enzymes ...
Mattie E. Hartauer, Raeanne M. Lanphier, Shivam Ohri, Jessica Snyder, Jacqueline B. Tiley, John K. Fallon, Henry Ho, Murat Cirit, Shiny Amala Priya Rajan, Kim L. R. Brouwer   +9 more
wiley   +1 more source

Impact of N-Acetylation on DNA Damage and Oxidative Stress Responses in Mammalian Cells and Human Hepatocytes Treated with Hydralazine

Biomolecules
Hydralazine is widely used to treat hypertension during pregnancy and has epigenetic effects in cancer therapy. Cryoplatable human hepatocytes showed concentration-dependent increase in DNA damage response (linear trend p = 0.0069) following 24 h ...
Mariam R. Habil, Makayla A. Stephens, Alexandra A. Cass, Elise M. Mittlestat, Darbie Kwon, Alexandra Ellison, J. Calvin Kouokam, David W. Hein   +7 more
doaj   +1 more source

Advances in New Approach Methodologies at FDA's Division of Applied Regulatory Science

Clinical Pharmacology &Therapeutics, Volume 120, Issue 5, Page 1250-1254, November 2026.
New Approach Methodologies (NAMs) represent a paradigm shift in drug development and regulatory science, offering human‐relevant alternatives to traditional preclinical models. This mini‐review highlights recent advances in NAM development, validation, and regulatory application from FDA's Division of Applied Regulatory Science (DARS).
Ksenia Blinova, Kimberly Chiu, Anik Chaturbedi, Jahan Cooper, Tromondae K. Feaster, Paula L. Hyland, Lidiya Stavitskaya, Wendy W. Wu, Jeffry Florian, Rodney Rouse   +9 more
wiley   +1 more source

CYP1A2 polymorphism does not modulate caffeine's effects on sprint performance or its metabolites during a soccer match simulation [PDF]

, 2017
The effectiveness of caffeine supplementation on exercise performance varies between individuals. Cytochrome P450 1A2 (CYP1A2) is an important enzyme that controls the primary catabolism of caffeine to paraxanthine, theobromine and theophylline, which ...
C.K. Chan, Devlin, B., B. Devlin, M. Kingsley, Belski, R., R. Belski, Kingsley, M., M. Leveritt, M., Kingsley, Chan, C.K., Leveritt, M.   +10 more
core   +1 more source

Beneficial Role of Natural Polyphenols Against Epilepsy: Greasing the Wheels of Pharmacotherapy Research for Epilepsy

Food Frontiers, Volume 7, Issue 6, November 2026.
ABSTRACT Epilepsy is the most disabling neurological disease that affects all economic classes, age groups, regions, and races. Although many antiseizure drugs are approved for epilepsy treatment, they fail to work in about 30%–40% of patients. Thus, there is a great need to identify better pharmacological agents to treat epilepsy.
Janakiraman Pillai Udaiyappan, Rengasamy Balakrishnan, Manivasagam Muthukumaran Tamilarasan, Subasri Pandian   +3 more
wiley   +1 more source

Tropoxine in the effective dose does not affect on activity of CYP2С9 and CYP1А2 isoforms of cytochrome P450 in rats

Фармакокинетика и Фармакодинамика, 2017
Effects of tropoxine on activity of isoforms CYP2С9 and CYP2С9 of cytochrome P450 using marker drugs losartane and caffeine were studied. Tropoxine in the effective dose (30 mg/kg) after 4-days intraperitoneal administration (3 times per day) in rats did
V. P. Zherdev, G. B. Kolyvanov, A. A. Litvin, O. G. Grybakina, P. O. Bochkov, R. V. Shevchenko   +5 more
doaj  

Physical interaction between CYP1A2 and CYP2B4 causes a disruption of inhibitory CYP1A2 complexes (LB592)

The FASEB Journal, 2014
Previous reports showed that CYP1A2 and CYP2B4 can affect each other’s activity when present in the same vesicles with subsaturating NADPH‐P450 reductase (CPR). Specifically, systems containing both P450s exhibited increased CYP1A2 and decreased CYP2B4 activities when compared with those containing each P450 alone.
John Connick, James Reed, Wayne Backes
openaire   +1 more source

Smokeless Tobacco‐Associated Nitrosamines Impact on Aryl Hydrocarbon Receptor: In Silico and In Vitro Study

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 11, November 2026.
Schematic representation of STE (smokeless tobacco extract) impact on AhR and AhR‐related genes. TSNAs present in STE induce AhR that results in to AhR conformational changes and translocation to the nucleus. Inside the nucleus, AhR heterodimerizes with Arnt and binds to XRE region of genome.
Mohammad Sajid, Ved Vrat Verma, Varun Rawat, Sonal Srivastava, Pragya Sharma, Mausumi Bharadwaj   +5 more
wiley   +1 more source

A 6-year retrospective study of olanzapine plasma concentration inpatients with schizophrenia CYP1A2 polymorphisms in real-life settings

Heliyon
Aim: to investigate the potential influence of CYP1A2 polymorphisms on olanzapine plasma concentration of inpatients with schizophrenia in real-life settings.
Yan Zhang, Lisha Sun, Yanli Su, Hui Wang
doaj   +1 more source

INDUCTION OF CYP1A2 WITH AROMATIC AMINES

Drug Metabolism and Pharmacokinetics, 1995
Male F344 rats were treated with a chemical (aniline, nitrobenzene, 2-methoxy-p-phenylenediamine, 2-methoxy-4-nitroaniline or 2-methoxy-4-nitroazobenzene) produced by the azo-reduction and/or N-oxidation of 2-methoxy-4-aminoazobenzene, a selective inducer of CYP1A2, and effects of their chemicals on CYP1A induction in the liver were examined at the ...
DEGAWA, Masakuni, NAKAYAMA, Masafumi, FUKUDA, Katsuyuki, SENZAKI, Kouji, YAMAZOE, Yasushi   +4 more
openaire   +2 more sources