Results 161 to 170 of about 13,799 (198)

CYP1B1 gene in endometrial cancer

Molecular and Cellular Endocrinology, 2003
Metabolic activation of estradiol has been shown to be a key factor in endometrial carcinogenesis. 4-hydroxy estrogens (CYP1B1 metabolites) received particular attention because of their causative role in malignant transformation of various organs including endometrium. CYP1B1 displays the highest level of expression in endometrium. 4-hydroxy estrogens
Masahiro, Sasaki, Masanori, Kaneuchi, Seiichiro, Fujimoto, Yuichiro, Tanaka, Rajvir, Dahiya   +4 more
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CYP1B1 and hormone-induced cancer

Cancer Letters, 2012
Cancers in hormone-responsive tissues (e.g., breast, ovary, endometrium, prostate) occur at high incidence rates worldwide. However, their genetic basis remains poorly understood. Studies to date suggest that endogenous/exogenous oestrogen and environmental carcinogens may play a role in development and/or progression of hormone-induced cancers via ...
Ketan, Gajjar, Pierre L, Martin-Hirsch, Francis L, Martin   +2 more
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Enhanced expression of CYP1B1 in Escherichia coli

Toxicology, 2000
Conditions for the optimal expression of the human CYP1B1 hemoprotein in Escherichia coli have been investigated. CYP1B1 cDNA was prepared from a retinal cDNA template and used to generate cDNA fragments with modified 5'-sequences reported to allow enhanced expression in E. coli DH5alpha.
I, Jansson, I, Stoilov, M, Sarfarazi, J B, Schenkman   +3 more
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CYP1B1: A Unique Gene with Unique Characteristics

Current Drug Metabolism, 2015
CYP1B1, a recently described dioxin inducible oxidoreductase, is a member of the cytochrome P450 superfamily involved in the metabolism of estradiol, retinol, benzo[a]pyrene, tamoxifen, melatonin, sterols etc. It plays important roles in numerous physiological processes and is expressed at mRNA level in many tissues and anatomical compartments.
Muneeb A, Faiq, Rima, Dada, Reetika, Sharma, Daman, Saluja, Tanuj, Dada   +4 more
openaire   +2 more sources

CYP1B1: A Promising Target in Cancer Drug Discovery

Anti-Cancer Agents in Medicinal Chemistry, 2023
Abstract: CYP1B1 plays an essential role in cancer's pathogenesis since it activates procarcinogens. Significantly, this enzyme catalyzes the hydroxylation of 17β-estradiol, leading to carcinogenic metabolites involved in carcinogenesis and cancer progression.
Marciéli Fabris, Mariana Luiza Silva, Kaio Maciel de Santiago-Silva, Marcelle de Lima Ferreira Bispo, Priscila Goes Camargo   +4 more
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CYP1B1 and predisposition to breast cancer in Poland

Breast Cancer Research and Treatment, 2007
The CYP1B1 gene is a polymorphic member of the P450 gene family and is considered to be a candidate gene for cancers of various types.We inquired whether four SNPs in the CYP1B1 gene, alone or in combination, might be associated with breast cancer risk in Poland.We genotyped 2017 cases of breast cancer and 876 controls, for four SNPs in the CYP1B1 gene.
Joanna, Matyjasik, Cezary, Cybulski, Bartlomiej, Masojć, Anna, Jakubowska, Pablo, Serrano-Fernandez, Bohdan, Górski, Tadeusz, Debniak, Tomasz, Huzarski, Tomasz, Byrski, Jacek, Gronwald, Elzbieta, Złowocka, Steven Alexander, Narod, Rodney, Scott, Jan, Lubinski   +13 more
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No Effect of CYP1B1 Val432Leu Polymorphism on CYP1B1 Messenger RNA Levels in an Organochlorine-Exposed Population in Slovakia

Cancer Epidemiology, Biomarkers & Prevention, 2005
Cytochrome P450 1B1 (CYP1B1) is a phase I enzyme involved in the metabolic activation of many polycyclic aromatic hydrocarbons. It is also involved in the hydroxylation of estradiol to 4-hydroxyestradiol, a potentially genotoxic metabolite that is suggested to play a role in carcinogenesis ...
van Duursen, M.B.M., Fernández Cantón, R., Kočan, T., Sanderson, J.T., Kieviet, K., van den Berg, M.   +5 more
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CYP1B1 Cytopathy: Uncommon Phenotype of a Homozygous CYP1B1 Deletion as Internal Corneal Ulcer of Von Hippel

Cornea, 2017
Purpose: To report a mutation of CYP1B1 in a newborn with a rare phenotype without the classic features of anterior segment dysgenesis or congenital glaucoma. Methods: The newborn presented with diffuse corneal edema and bilaterally elevated intraocular pressure (IOP ...
Valeria, Oliva-Biénzobas, Alejandro, Navas, Mirena, C Astiazarán, Oscar Francisco, Chacón-Camacho, Jose, A Bermúdez-Magner, Mariana, Takane, Enrique, Graue-Hernández, Juan Carlos, Zenteno   +7 more
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Discovery of Highly Selective CYP1B1 Inhibitors

Journal of Medicinal Chemistry
Tumor-drug resistance remains a critical challenge in pharmaceutical research. Recent studies have identified CYP1B1 as a potential target mediating paclitaxel resistance. In this study, we employed structure-based drug design to synthesize a series of thiazoleamide derivatives, leading to the identification of multiple potent and selective CYP1B1 ...
Ting Wang, Haoyu Zhang, Dihan Tan, Ningyi Qin, Bohou Song, Pengfei Song, Yang Liu, Dongmei Zhao, Gang Xing, Maosheng Cheng   +9 more
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Increase of human CYP1B1 activities by acidic phospholipids and kinetic deuterium isotope effects on CYP1B1 substrate oxidation

The Journal of Biochemistry, 2012
The effect of phospholipids on the kinetic parameters of three substrates, 7-ethoxy-4 -(trifluoromethyl)coumarin (7-EFC), 7-ethoxycoumarin (7-EC) and 17β-estradiol (E(2)), of human CYP1B1 was studied. In general, anionic phospholipids, phosphatidic acid and cardiolipin increased catalytic efficiency by increasing k(cat) values or decreasing K(m) values.
Hyun-Hee, Jang, So-Young, Kim, Ji-Yeon, Kang, Seon Ha, Park, Sang Hoon, Ryu, Taeho, Ahn, Chul-Ho, Yun   +6 more
openaire   +2 more sources