Results 171 to 180 of about 13,799 (198)

Influence of the Cyp1B1 L432V Gene Polymorphism and Exposure to Tobacco Smoke on Cyp1B1 mRNA Expression in Human Leukocytes

Drug Metabolism and Disposition, 2009
Cytochrome P450 1B1 (CYP1B1), a phase I enzyme, is involved in the activation of a broad spectrum of procarcinogens. An association of the Cyp1B1 L432V polymorphism with diverse types of cancer, as well as an impact on the catalytic activity of the enzyme, has been described.
Simone, Helmig, Bahar, Hadzaad, Juliane, Döhrel, Joachim, Schneider   +3 more
openaire   +2 more sources

Constitutive expression and induction of CYP1B1 mRNA in the mouse

Journal of Biochemical and Molecular Toxicology, 1999
Previous studies appeared to indicate that CYP1B1 was not constitutively expressed in mouse liver. In our laboratory, we demonstrated using aromatic hydrocarbon-responsive receptor knock-out (AHR-(-)/-) mice that both piperonyl butoxide (PBO) and acenaphtyhlene (ACN) are AHR-independent inducers of murine CYP1A2 and CYP1B1 mRNA.
D Y, Ryu, E, Hodgson
openaire   +2 more sources

Selective inhibition of methoxyflavonoids on human CYP1B1 activity

Bioorganic & Medicinal Chemistry, 2010
Cytochrome P450 (CYP) 1B1 catalyzes 17beta-estradiol (E(2)) to predominantly carcinogenic 4-hydroxy-E(2), whereas CYP1A1 and 1A2 convert E(2) to non-carcinogenic 2-hydroxy-E(2). Hence, selective inhibition of CYP1B1 is recognized to be beneficial for the prevention of E(2) related breast cancer.
Hitomi, Takemura, Toshimasa, Itoh, Keiko, Yamamoto, Hiroyuki, Sakakibara, Kayoko, Shimoi   +4 more
openaire   +2 more sources

Biphenyl urea derivatives as selective CYP1B1 inhibitors

Organic & Biomolecular Chemistry, 2016
Herein, we report the discovery of ‘biphenyl ureas’ as selective CYP1B1 inhibitors.
Siddique, Mohd Usman Mohd, Sonawane, Vinay, Horley, Neill, Williams, Ibidapo Steven, Joshi, Prashant, Bharate, Sandip B., Jayaprakash, Venkatesan, Sinha, Barij N., Chaudhuri, Bhabatosh, McCann, Glen J. P.   +9 more
openaire   +2 more sources

CYP1B1 expression in human lung.

Drug metabolism and disposition: the biological fate of chemicals, 2001
Cytochrome P450 1B1 is a recently recognized phase I bioactivating enzyme with high affinity for both inhaled tobacco carcinogens and 17beta-estradiol. We evaluated the human lung expression of this multifunctional member of the P450 superfamily across 16 individuals.
S D, Spivack, G J, Hurteau, A A, Reilly, K M, Aldous, X, Ding, L S, Kaminsky   +5 more
openaire   +1 more source

CYP1B1

1998
Tak W. Mak, Josef Penninger, John Roder, Janet Rossant, Mary Saunders   +4 more
openaire   +1 more source

Synthesis and Structure-Activity Relationship Studies of α-Naphthoflavone Derivatives as CYP1B1 Inhibitors

European Journal of Medicinal Chemistry, 2020
Zengtao Wang, Qingqing Meng, Jia-Hua Cui
exaly  

Design and Synthesis of α-Naphthoflavone Chimera Derivatives Able to Eliminate Cytochrome P450 (CYP)1B1-Mediated Drug Resistance via Targeted CYP1B1 Degradation

European Journal of Medicinal Chemistry, 2020
Jiliang Hu, Wen Zhou, Ling-Li Wang
exaly  

A New Class of CYP1B1 Inhibitors Derived From Bentranil

Bioorganic and Medicinal Chemistry Letters, 2023
Fengyuan Yang, Jianhua Jia, Huang Xinyue
exaly  

Gene symbol: CYP1B1.

Human genetics, 2007
Kunal, Ray, Moulinath, Acharya, Suddhasil, Mookherjee   +2 more
openaire   +5 more sources