Results 1 to 10 of about 1,002 (150)

Genotype of Null Polymorphisms in Genes GSTM1, GSTT1, CYP1A1, and CYP1A1*2A (rs4646903 T>C)/CYP1A1*2C (rs1048943 A>G) in Patients with Larynx Cancer in Southeast Spain [PDF]

Cancers, 2020
Background: some types of cancer have been associated with the presence of single nucleotide polymorphisms (SNPs) of some genes that encode enzymes: glutathione-S transferase (GST), whose alteration leads to loss of function and a lower capacity to eliminate toxic GSTM1 and GSTT1 null genotypes; SNPs causing loss of function of CYP1A1 or CYP1A1–2 ...
Juan Cabezas-Herrera, FRANCISCO Pastor Quirante, Fabio Camacho-Alonso   +2 more
exaly   +3 more sources

Discovery of a novel AhR–CYP1A1 axis activator for mitigating inflammatory diseases using an in situ functional imaging assay

Acta Pharmaceutica Sinica B
The aryl hydrocarbon receptor (AhR) plays a crucial role in regulating many physiological processes. Activating the AhR–CYP1A1 axis has emerged as a novel therapeutic strategy against various inflammatory diseases.
Mengru Sun, Yufan Fan, Hairong Zeng
exaly   +3 more sources

Inhibition of CYP1A1 Alleviates Colchicine-Induced Hepatotoxicity

Toxins
Colchicine, a natural compound extracted from Colchicum autumnale, is a phytotoxin, but interestingly, it also has multiple pharmacological activities.
Ruoyue Huang, Jingyi Duan, Wen Huang, Yan Cheng, Beiwei Zhu, Fei Li   +5 more
doaj   +3 more sources

LPS inhibits arginase-1 expression in macrophages by up-regulating activity of cytochrome P450 1A1 epoxidase

陆军军医大学学报, 2023
Objective To explore the regulative effect and mechanism of cytochrome P450 1A1 (CYP1A1) on regulating lipopolysaccharide (LPS)-induced arginase-1 (Arg-1) expression in macrophages. Methods After mouse macrophage-like cell line RAW264.7 (RAW) was treated
TIAN Lixing, ZHU Junyu, WAN Linghui, LIANG Huaping   +3 more
doaj   +1 more source

Genetic polymorphism of carcinogen metabolic enzymes in oral submucous fibrosis

Journal of Indian Academy of Oral Medicine and Radiology, 2022
Background: Biotransformation plays a crucial role in carcinogen activity. Genetic polymorphisms in xenobiotic-metabolizing enzymes crucial to a carcinogen and drug metabolism lead to variations in their activity. These enzymes increase cancer risk by an
Sunu Ramachandran, Anita Balan, C Tinky Bose, Prabha Balaram, V Nityasri   +4 more
doaj   +1 more source

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

Defining the Contribution of CYP1A1 and CYP1A2 to Drug Metabolism Using Humanized CYP1A1/1A2 and Cyp1a1/Cyp1a2 Knockout Mice [PDF]

Drug Metabolism and Disposition, 2019
Cytochrome P450s CYP1A1 and CYP1A2 can metabolize a broad range of foreign compounds and drugs. However, these enzymes have significantly overlapping substrate specificities. To establish their relative contribution to drug metabolism in vivo, we used a combination of mice humanized for CYP1A1 and CYP1A2 together with mice nulled at the Cyp1a1 and ...
Y. Kapelyukh, C.J. Henderson, N. Scheer, A. Rode, C.R. Wolf   +4 more
openaire   +3 more sources

Genetic Variants of CYP11B2 and CYP1A1 Among the North-Indian Punjabi Females with Polycystic Ovary Syndrome

Korean Journal of Clinical Laboratory Science, 2022
Polycystic ovary syndrome (PCOS) is a complex endocrinopathy in women of reproductive age. The genetics of PCOS is heterogeneous with the involvement of number of genes in the steroid synthesis pathway.
Ratneev Kaur, Mandeep Kaur, Sukhjashanpreet Singh, Tajinder Kaur, Anupam Kaur   +4 more
doaj   +1 more source

Induction of pulmonary CYP1A1 by nicotine [PDF]

Xenobiotica, 1998
1. We have examined the catalytic activities (7-ethoxyresorufin O-deethylase [EROD] and 7-methoxyresorufin O-demethylase [MROD]), protein levels (Western blot analysis) and mRNA levels (Northern blot analysis) of cytochrome P4501A (CYP1A1 and CYP1A2) in the lung, liver and kidney following a single 2.5 mg/kg (15.4 micromol/kg) subcutaneous dose of ...
M M, Iba, H, Scholl, J, Fung, P E, Thomas, J, Alam   +4 more
openaire   +3 more sources

Association of CYP1A1*2A Polymorphism with Idiopathic Non-Obstructive Azoospermia in A South Indian Cohort [PDF]

International Journal of Fertility and Sterility, 2017
Background: Infertility is the inability of a couple to conceive after one and a half years of unprotected sex. Male infertility, which accounts for almost half of infertility cases, is considered as a major problem all over the world.
Shalaka S Ramgir, Nishu Sekar, Divya Jindam., Abilash V.G.   +3 more
doaj   +1 more source