Results 1 to 10 of about 12,119 (136)

AhR Regulates the Expression of Human Cytochrome P450 1A1 (CYP1A1) by Recruiting Sp1

FEBS Journal, 2019
Cytochrome P450 1A1 (CYP1A1) is abundant in the kidney, liver, and intestine and is involved in the phase I metabolism of numerous endogenous and exogenous compounds.
Jikai Wen, Yiqun Deng, Xiaoxuan Chen
exaly   +2 more sources

Serotonin is an endogenous regulator of intestinal CYP1A1 via AhR

Scientific Reports, 2018
Aryl hydrocarbon receptor (AhR) is a nuclear receptor that controls xenobiotic detoxification via induction of cytochrome P450 1A1 (CYP1A1) and regulates immune responses in the intestine.
Christopher Manzella, Megha Singhal, Waddah A. Alrefai, Seema Saksena, Pradeep K. Dudeja, Ravinder K. Gill   +5 more
doaj   +2 more sources

CYP1A1 methylation mediates the effect of smoking and occupational polycyclic aromatic hydrocarbons co-exposure on oxidative DNA damage among Chinese coke-oven workers

Environmental Health, 2019
Background Multiple factors, including co-exposure between lifestyle and environmental risks, are important in susceptibility to oxidative DNA damage. However, the underlying mechanism is not fully understood.
Yanli Liu, Xuejing Li, Bin Zhang, Ye Fu, Aimin Yang, Hongjie Zhang, Huitao Zhang, Yingying Niu, Jisheng Nie, Jin Yang   +9 more
doaj   +2 more sources

Berberine Activates Aryl Hydrocarbon Receptor but Suppresses CYP1A1 Induction through miR-21-3p Stimulation in MCF-7 Breast Cancer Cells

Molecules, 2017
Berberine and the methylenedioxy ring-opening derivatives palmatine and jatrorrhizine are active ingredients in immunomodulatory plants, such as goldenseal.
Sheng-Nan Lo, Chun-Wei Wang, Yueh-Shieh Chen, Chiung-Chiao Huang, Tian-Shung Wu, Lih-Ann Li, I-Jung Lee, Yune-Fang Ueng   +7 more
doaj   +2 more sources

Discovery of a Novel AhR–CYP1A1 Axis Activator for Mitigating Inflammatory Diseases Using an in Situ Functional Imaging Assay

Acta Pharmaceutica Sinica B
The aryl hydrocarbon receptor (AhR) plays a crucial role in regulating many physiological processes. Activating the AhR–CYP1A1 axis has emerged as a novel therapeutic strategy against various inflammatory diseases.
Mengru Sun, Yufan Fan, Bei Zhao
exaly   +3 more sources

PM2.5 leads to adverse pregnancy outcomes by inducing trophoblast oxidative stress and mitochondrial apoptosis via KLF9/CYP1A1 transcriptional axis

eLife, 2023
Epidemiological studies have demonstrated that fine particulate matter (PM2.5) is associated with adverse obstetric and postnatal metabolic health outcomes, but the mechanism remains unclear.
Shu-Xian Li, Ling-Bing Li, Chang-Qing Zhang, Huaxuan Fu, Shuping Yu, Mei-Juan Zhou, Jun-Hong Guo, Zhenya Fang, Anna Li, Man Zhao, Mei-Hua Zhang, Xie-Tong Wang   +11 more
semanticscholar   +1 more source

Pharmacological blockage of the AHR-CYP1A1 axis: a call for in vivo evidence

Journal of molecular medicine, 2021
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that can be activated by structurally diverse compounds arising from the environment and the microbiota and host metabolism.
N. Coelho, A. Pimpão, M. Correia, T. Rodrigues, E. Monteiro, J. Morello, S. Pereira   +6 more
semanticscholar   +1 more source

The genotoxicity potential of luteolin is enhanced by CYP1A1 and CYP1A2 in human lymphoblastoid TK6 cells

Toxicology Letters, 2021
Luteolin (5,7,3′,4′-tetrahydroxyflavone) belongs to the flavone subclass of flavonoids. Luteolin and its glycosides are present in many botanical families, including edible plants, fruits, and vegetables.
Xi-Lin Li, Xiaobo He, Si Chen, Yuan Le, M. Bryant, Lei Guo, K. Witt, Nan Mei   +7 more
semanticscholar   +1 more source

LPS inhibits arginase-1 expression in macrophages by up-regulating activity of cytochrome P450 1A1 epoxidase

陆军军医大学学报, 2023
Objective To explore the regulative effect and mechanism of cytochrome P450 1A1 (CYP1A1) on regulating lipopolysaccharide (LPS)-induced arginase-1 (Arg-1) expression in macrophages. Methods After mouse macrophage-like cell line RAW264.7 (RAW) was treated
TIAN Lixing, ZHU Junyu, WAN Linghui, LIANG Huaping   +3 more
doaj   +1 more source

Genetic polymorphism of carcinogen metabolic enzymes in oral submucous fibrosis

Journal of Indian Academy of Oral Medicine and Radiology, 2022
Background: Biotransformation plays a crucial role in carcinogen activity. Genetic polymorphisms in xenobiotic-metabolizing enzymes crucial to a carcinogen and drug metabolism lead to variations in their activity. These enzymes increase cancer risk by an
Sunu Ramachandran, Anita Balan, C Tinky Bose, Prabha Balaram, V Nityasri   +4 more
doaj   +1 more source