Results 21 to 30 of about 1,002 (150)

Signal integration by the CYP1A1 promoter -- a quantitative study [PDF]

Nucleic Acids Research, 2015
Genes involved in detoxification of foreign compounds exhibit complex spatiotemporal expression patterns in liver. Cytochrome P450 1A1 (CYP1A1), for example, is restricted to the pericentral region of liver lobules in response to the interplay between aryl hydrocarbon receptor (AhR) and Wnt/β-catenin signaling pathways. However, the mechanisms by which
Schulthess, P., Löffler, A., Vetter, S., Kreft, L., Schwarz, M., Braeuning, A., Blüthgen, N.   +6 more
openaire   +4 more sources

Modulation of CYP1A1 and CYP1A2 hepatic enzymes after oral administration of Chios mastic gum to male Wistar rats. [PDF]

PLoS ONE, 2014
Chios mastic gum (CMG), a resin derived from Pistacia lentiscus var. chia, is known since ancient times for its pharmacological activities. CYP1A1 and CYP1A2 enzymes are among the most involved in the biotransformation of chemicals and the metabolic ...
Efrosini S Katsanou, Katerina Kyriakopoulou, Christina Emmanouil, Nikolas Fokialakis, Alexios-Leandros Skaltsounis, Kyriaki Machera   +5 more
doaj   +1 more source

The Host CYP1A1-Microbiota Metabolic Axis Promotes Gut Barrier Disruption in Methicillin-Resistant Staphylococcus aureus-Induced Abdominal Sepsis

Frontiers in Microbiology, 2022
BackgroundHost-microbiota crosstalk has been implicated in multiple host metabolic pathway axes that regulate intestinal barrier function. Although constitutive cytochrome P4501A1 (CYP1A1) expression perturbs the microbiome-derived autoregulatory loop ...
Xiaoyuan Ma, Huaijian Jin, Huaijian Jin, Xiang Chu, Weihong Dai, Wanqi Tang, Junyu Zhu, Fangjie Wang, Xue Yang, Wei Li, Guodong Liu, Guodong Liu, Xia Yang, Huaping Liang   +13 more
doaj   +1 more source

Sp1, Instead of AhR, Regulates the Basal Transcription of Porcine CYP1A1 at the Proximal Promoter

Frontiers in Pharmacology, 2018
Pigs are commonly used as an animal model to evaluate the toxic effects of exogenous compounds. Cytochrome P450 1A1 (CYP1A1) metabolizes numerous exogenous compounds and is abundantly expressed in the liver, kidneys, and intestines.
Xuan Xie, Xuan Xie, Jun Jiang, Jun Jiang, Wenchu Ye, Wenchu Ye, Ruohong Chen, Ruohong Chen, Yiqun Deng, Yiqun Deng, Jikai Wen, Jikai Wen   +11 more
doaj   +1 more source

Expression and Sequence of CYP1A1 in the Camel

Journal of Veterinary Medical Science, 2010
In this study, we determined a partial sequence of CYP1A1 in the camel and its phylogenetic position. The deduced amino acid sequence of camel CYP1A1 showed the highest identity 94% with those of sheep and cattle CYP1A1. In a phylogenetic analysis, the camel CYP1A1 isoform was located beside sheep and cattle CYP1A1.
DARWISH, Wageh Sobhy, MORSHDY, Alaa Eldin, IKENAKA, Yoshinori, IBRAHIM, Zein Shaban, FUJITA, Shoichi, ISHIZUKA, Mayumi   +5 more
openaire   +3 more sources

Inhibition of CYP1A1 by pharmaceutical drugs, omeprazol and ketoconazole as a mechanism for activation of aryl hydrocarbon receptor (AHR) [PDF]

Trends in Pharmaceutical Sciences, 2017
Omeprazole (OMP) and ketoconazole (KTZ) have been shown to activate the AHR signaling pathway in spite of the fact that they bind to the receptor with low or no affinity.
Ali Ghaffarian-Bahraman, Nilofar Sadeghimanesh, Mona Mirzaei, Amin-Reza Akbarizadeh, Mahmoud Omidi, Hamidreza Mohammadi, Mohammad-Reza Arabnezhad, Keivan Mobini, Afshin Mohammadi-Bardbori   +8 more
doaj  

Interaction between maternal passive smoking during pregnancy and CYP1A1 and GSTs polymorphisms on spontaneous preterm delivery. [PDF]

PLoS ONE, 2012
OBJECTIVE: The present study aimed to examine the association between maternal passive smoking during pregnancy and the risk of spontaneous PTD and to explore the potential interaction of the single or joint gene polymorphism of CYP1A1 and GSTs with ...
Yi-Juan Luo, Xiao-Zhong Wen, Peng Ding, Yan-Hui He, Chuan-Bo Xie, Tao Liu, Jian-Miao Lin, Shi-Xin Yuan, Xiao-Ling Guo, De-Qin Jia, Li-Hua Chen, Bao-Zhen Huang, Wei-Qing Chen   +12 more
doaj   +1 more source

Interaction between CYP1A1 gene polymorphism and environment factors on risk of endometrial cancer

Environmental Health and Preventive Medicine
Background: The purpose of this study was to investigate the impact of single nucleotide polymorphisms (SNPs) of the CYP1A1 gene and the gene-environment interaction on the susceptibility to endometrial cancer in Chinese women.
Jian Xu, Cheng Tan
doaj   +1 more source

Polymorphisms of CYP1A1, CYP1A2, CYP19, and SULT1A1 genes in women with early miscarriage

Фундаментальная и клиническая медицина, 2019
Aim. To determine the frequency of the polymorphisms within the genes encoding estrogen metabolism enzymes: CYP1A1 (rs4646903), CYP1A2 (rs762551), CYP19 (rs700519) and SULT1A1 (rs9282861) in women with early miscarriage.Materials and Methods.
I. N. Noskova, N. V. Artymuk, L. F. Gulyaeva   +2 more
doaj   +1 more source

Expression profiles of CYP1A1 and CYP1B1 enzymes in Non-small Cell Lung Cancer of Turkish Patients

Сибирский онкологический журнал
Background. The cytochrome P450 enzymes CYP1A1 and CYP1B1 are involved in the metabolism of carcinogens and have been linked to various cancers, including lung cancer, primarily through their overexpression in tumor tissues. Aim of study.
H. Bayram, O. Dirican, P. Kaygın, K. Başak, A. A. Husseini, M. Atlı, F. Ç. Kazancı, S. Oğuztüzün   +7 more
doaj   +1 more source