Results 21 to 30 of about 34,953 (257)

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

Genetic Variants of CYP11B2 and CYP1A1 Among the North-Indian Punjabi Females with Polycystic Ovary Syndrome

Korean Journal of Clinical Laboratory Science, 2022
Polycystic ovary syndrome (PCOS) is a complex endocrinopathy in women of reproductive age. The genetics of PCOS is heterogeneous with the involvement of number of genes in the steroid synthesis pathway.
Ratneev Kaur, Mandeep Kaur, Sukhjashanpreet Singh, Tajinder Kaur, Anupam Kaur   +4 more
doaj   +1 more source

How the AHR Became Important in Intestinal Homeostasis—A Diurnal FICZ/AHR/CYP1A1 Feedback Controls Both Immunity and Immunopathology

International Journal of Molecular Sciences, 2020
Ever since the 1970s, when profound immunosuppression caused by exogenous dioxin-like compounds was first observed, the involvement of the aryl hydrocarbon receptor (AHR) in immunomodulation has been the focus of considerable research interest.
A. Rannug
semanticscholar   +1 more source

CYP1A1 Enzymatic Activity Influences Skin Inflammation Via Regulation of the AHR Pathway

Journal of Investigative Dermatology, 2020
The AHR is an environmental sensor and transcription factor activated by a variety of man-made and natural ligands, which has recently emerged as a critical regulator of homeostasis at barrier organs such as the skin.
Mariela Kyoreva, Ying Li, Mariyah Hoosenally, J. Hardman-Smart, Kirsten Morrison, I. Tosi, Mauro Tolaini, G. Barinaga, B. Stockinger, U. Mrowietz, F. Nestle, Catherine H. Smith, J. Barker, P. di Meglio   +13 more
semanticscholar   +1 more source

Induction of pulmonary CYP1A1 by nicotine [PDF]

Xenobiotica, 1998
1. We have examined the catalytic activities (7-ethoxyresorufin O-deethylase [EROD] and 7-methoxyresorufin O-demethylase [MROD]), protein levels (Western blot analysis) and mRNA levels (Northern blot analysis) of cytochrome P4501A (CYP1A1 and CYP1A2) in the lung, liver and kidney following a single 2.5 mg/kg (15.4 micromol/kg) subcutaneous dose of ...
M M, Iba, H, Scholl, J, Fung, P E, Thomas, J, Alam   +4 more
openaire   +3 more sources

Association of CYP1A1*2A Polymorphism with Idiopathic Non-Obstructive Azoospermia in A South Indian Cohort [PDF]

International Journal of Fertility and Sterility, 2017
Background: Infertility is the inability of a couple to conceive after one and a half years of unprotected sex. Male infertility, which accounts for almost half of infertility cases, is considered as a major problem all over the world.
Shalaka S Ramgir, Nishu Sekar, Divya Jindam., Abilash V.G.   +3 more
doaj   +1 more source

Potential of Inactivated Bifidobacterium Strain in Attenuating Benzo(A)Pyrene Exposure-Induced Damage in Colon Epithelial Cells In Vitro

Toxics, 2020
Long-term exposure to benzo(a)pyrene (BaP) poses a serious genotoxic threat to human beings. This in vitro study investigated the potential of inactivated Bifidobacterium animalis subsp.
Mengfan Xu, Lili Fu, Junwen Zhang, Tao Wang, Junfeng Fan, Baoqing Zhu, Piotr Dziugan, Bolin Zhang, Hongfei Zhao   +8 more
doaj   +1 more source

Polycyclic Aromatic Hydrocarbon (PAH)-Induced Pulmonary Carcinogenesis in Cytochrome P450 (CYP) 1A1- and 1A2-null Mice: Roles of CYP1A1 and CYP1A2.

Toxicological Sciences, 2020
In 2019, lung cancer was estimated to be the leading cause of cancer deaths in humans. Polycyclic aromatic hydrocarbons (PAHs) are known to increase the risk of lung cancer.
Grady Gastelum, Wei-Wu Jiang, Li-Hua Wang, Guo-Dong Zhou, Roshan Borkar, N. Putluri, B. Moorthy   +6 more
semanticscholar   +1 more source

Cytochrome P450 1A1 enhances inflammatory responses and impedes phagocytosis of bacteria in macrophages during sepsis

Cell Communication and Signaling, 2020
The hydroxylase cytochrome P450 1A1 (CYP1A1) is regulated by the inflammation-limiting aryl hydrocarbon receptor (AhR), but CYP1A1 immune functions remain unclear.
Li-Xing Tian, Xin Tang, Jun-Yu Zhu, Li Luo, Xiao-Yuan Ma, Shao-Wen Cheng, Wei Zhang, Wan-Qi Tang, Wei Ma, Xue Yang, Chuan-Zhu Lv, Hua-Ping Liang   +11 more
doaj   +1 more source

SNP genes of immune response mediators and predisposition to development of socially significant diseases

Медицинская иммунология, 2022
Allele typing of single-nucleotide polymorphisms (SNPs) may be used in predictive medicine and to determine targets for the most effective treatment strategies for various diseases.
E. A. Tatarkova, A. R. Tuguz, D. S. Shumilov, D. V. Muzhenya, K. A. Rudenko, I. V. Smolkov   +5 more
doaj   +1 more source