Results 41 to 50 of about 34,953 (257)
PLoS ONE, 2021 BackgroundNine previous meta-analyses have been published to analyze the CYP1A1 T3801C and A2455G polymorphisms with BC risk. However, they did not assess the credibility of statistically significant associations.
Chen Yang, Xiao-Feng He
doaj +1 more source
Chemical Research in Toxicology, 2019 Cytochrome P450s (CYPs), a superfamily of enzymes, are involved in the biotransformation of endogenous and xenobiotic chemicals and mainly responsible for the metabolic clearance of widely prescribed drugs.
D. Lang, M. Radtke, Michaela Bairlein
semanticscholar +1 more source
Signal integration by the CYP1A1 promoter -- a quantitative study [PDF]
Nucleic Acids Research, 2015 Genes involved in detoxification of foreign compounds exhibit complex spatiotemporal expression patterns in liver. Cytochrome P450 1A1 (CYP1A1), for example, is restricted to the pericentral region of liver lobules in response to the interplay between aryl hydrocarbon receptor (AhR) and Wnt/β-catenin signaling pathways. However, the mechanisms by which
Schulthess, P. +6 more
openaire +4 more sources
Heteromeric Complex Formation Between Human Cytochrome P450 CYP1A1 and Heme Oxygenase-1
, 2021 P450 and heme oxygenase-1 (HO-1) receive their necessary electrons by interaction with the NADPH-cytochrome P450 reductase (POR). As the POR concentration is limiting when compared with P450 and HO-1, they must effectively compete for POR to function. In
Reed, James R. +3 more
core +1 more source
Frontiers in Microbiology, 2022 BackgroundHost-microbiota crosstalk has been implicated in multiple host metabolic pathway axes that regulate intestinal barrier function. Although constitutive cytochrome P4501A1 (CYP1A1) expression perturbs the microbiome-derived autoregulatory loop ...
Xiaoyuan Ma +13 more
doaj +1 more source
Expression and Sequence of CYP1A1 in the Camel
Journal of Veterinary Medical Science, 2010 In this study, we determined a partial sequence of CYP1A1 in the camel and its phylogenetic position. The deduced amino acid sequence of camel CYP1A1 showed the highest identity 94% with those of sheep and cattle CYP1A1. In a phylogenetic analysis, the camel CYP1A1 isoform was located beside sheep and cattle CYP1A1.
DARWISH, Wageh Sobhy +5 more
openaire +3 more sources
Modulation of CYP1A1 and CYP1A2 hepatic enzymes after oral administration of Chios mastic gum to male Wistar rats. [PDF]
PLoS ONE, 2014 Chios mastic gum (CMG), a resin derived from Pistacia lentiscus var. chia, is known since ancient times for its pharmacological activities. CYP1A1 and CYP1A2 enzymes are among the most involved in the biotransformation of chemicals and the metabolic ...
Efrosini S Katsanou +5 more
doaj +1 more source
Serotonin Modulates AhR Activation by Interfering with CYP1A1-Mediated Clearance of AhR Ligands
Cellular Physiology and Biochemistry, 2019 Background/Aims: Serotonin (5-hydroxytryptamine, 5-HT) is a neurotransmitter and hormone with important physiological functions in many organs, including the intestine.
Christopher R. Manzella +8 more
semanticscholar +1 more source
Inhibition of CYP1A1 by pharmaceutical drugs, omeprazol and ketoconazole as a mechanism for activation of aryl hydrocarbon receptor (AHR) [PDF]
Trends in Pharmaceutical Sciences, 2017 Omeprazole (OMP) and ketoconazole (KTZ) have been shown to activate the AHR signaling pathway in spite of the fact that they bind to the receptor with low or no affinity.
Ali Ghaffarian-Bahraman +8 more
doaj
Interaction between CYP1A1 gene polymorphism and environment factors on risk of endometrial cancer
Environmental Health and Preventive MedicineBackground: The purpose of this study was to investigate the impact of single nucleotide polymorphisms (SNPs) of the CYP1A1 gene and the gene-environment interaction on the susceptibility to endometrial cancer in Chinese women.
Jian Xu, Cheng Tan
doaj +1 more source