Results 51 to 60 of about 15,644 (193)

A comprehensive meta-analysis and a case–control study give insights into genetic susceptibility of lung cancer and subgroups

Scientific Reports, 2021
Reports of genetic association of polymorphisms with lung cancer in the Indian subcontinent are often conflicting. To summarise and replicate published evidence for association with lung cancer and its subgroups. We performed a meta-analysis of candidate
Debmalya Sengupta, Souradeep Banerjee, Pramiti Mukhopadhyay, Ritabrata Mitra, Tamohan Chaudhuri, Abhijit Sarkar, Gautam Bhattacharjee, Somsubhra Nath, Susanta Roychoudhury, Samsiddhi Bhattacharjee, Mainak Sengupta   +10 more
doaj   +1 more source

CYP1A1 and Cnr nitroreductase bioactivated niclosamide in vitro [PDF]

Mutagenesis, 2013
Abstract Niclosamide produces genotoxic effects, such as point mutations in Salmonella sp., sperm-head abnormalities in mice and clastogenic effects in human lymphocytes in vitro and in vivo. As cytochrome P450 could be involved in the bioactivation of niclosamide, we investigated which subfamily was involved.
Evelyn, Beristain-Castillo, Mariano, Martínez-Vázquez, Rafael, Camacho-Carranza, Javier J, Espinosa-Aguirre   +3 more
openaire   +2 more sources

Daytime Restricted Feeding Modifies the Temporal Expression of CYP1A1 and Attenuated Damage Induced by Benzo[a]pyrene in Rat Liver When Administered before CYP1A1 Acrophase

Toxics, 2021
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that heterodimerizes with the AhR nuclear translocator (ARNT) to modulate CYP1A1 expression, a gene involved in the biotransformation of benzo[a]pyrene (BaP).
Oscar Samuel Ávila-Rosales, Mauricio Díaz-Muñoz, Rafael Camacho-Carranza, Elvia Coballase-Urrutia, José Pedraza-Chaverri, Jorge Omar García-Rebollar, Jesús Javier Espinosa-Aguirre   +6 more
doaj   +1 more source

CYP1A1, Cigarette Smoking, and Colon and Rectal Cancer [PDF]

American Journal of Epidemiology, 2004
Cytochrome P-450 (CYP) is involved in the activation and metabolism of polycyclic aromatic hydrocarbons in tobacco products. The authors evaluated the association of two polymorphisms in the CYP1A1 gene--the noncoding Msp I polymorphism in the 3'-untranslated region and the Ile462Val polymorphism in exon 7--with colon and rectal cancer.
Martha L, Slattery, W, Samowtiz, K, Ma, M, Murtaugh, C, Sweeney, T R, Levin, S, Neuhausen   +6 more
openaire   +2 more sources

Environmental Pesticide Exposure in the Etiology of Pediatric Brain Tumors and Leukemia: A Scoping Review of Epidemiological Studies

International Journal of Cancer, EarlyView.
ABSTRACT Pediatric cancer is a significant cause of morbidity and mortality in children. The etiologies of pediatric cancer are largely unknown, but environmental pesticide exposures are likely to contribute. Chronic low‐dose exposure to pesticide mixtures through drinking water is a growing concern in agricultural communities.
Grace N. VanDeSteeg, Alyssa R. Russum, Matthew R. Sandbulte, Eleanor G. Rogan, Martha G. Rhoades   +4 more
wiley   +1 more source

The Impact of Genetic Polymorphisms on Genotoxicity (DNA Damage) Among Children Exposed to Environmental Mutagens: A Systematic Review

Journal of Applied Toxicology, EarlyView.
ABSTRACT Children, as a particularly vulnerable group, are more susceptible to these mutagens due to their developing immune systems, higher physiological vulnerability, and increased exposure through behaviors like outdoor play and hand‐to‐mouth activities. This review aims to investigate the relationship between these environmental exposures, genetic
Thiago Guedes Pinto, Daniel Vitor de Souza, Gabriel Carvalhal de Aguiar, Ana Claudia Muniz Renno, Patricia Ramos Cury, Jean Nunes dos Santos, Rogerio Aparecido Dedivitis, Daniel Araki Ribeiro   +7 more
wiley   +1 more source

Kaempferol Protects Intestinal Health in Chinese Forest Musk Deer Possibly by Regulating Intestinal Microbiota and Inhibiting the NF‐κB/NLRP3 Signaling Pathway

Integrative Zoology, EarlyView.
Kaempferol modulates the tryptophan metabolism pathway by increasing the abundances of Christensenellaceae R7 group, Bacteroides, and Blautia and reducing that of Rikenellaceae RC9 gut group, thereby significantly increasing the levels of ILA and IAA. This process inhibits the activation of NF‐κB/NLRP3 signaling pathway, reduces pro‐inflammatory factor
Xiangyu Liu, Zhanjun Ren, Xiuzhu Sun, Shuhui Wang   +3 more
wiley   +1 more source

POLYMORPHISMS OF THE CYP1A1, CYP1A2, CYP19, AND SULT1A1 GENES ARE NOT ASSOCIATED WITH INFERTILITY IN WOMEN WITH GENITAL ENDOMETRIOSIS

Фундаментальная и клиническая медицина, 2018
Aim. To estimate whether CYP1A1, CYP1A2, CYP19, SULT1A1 gene polymorphisms are associated with genital endometriosis in infertile women. Materials and Methods.
LARISA N. Danilova, VITALIY O. Chervov, NATALIA V. Artymuk, LYUDMILA A. Gordeeva   +3 more
doaj  

Serotonin is an endogenous regulator of intestinal CYP1A1 via AhR

Scientific Reports, 2018
Aryl hydrocarbon receptor (AhR) is a nuclear receptor that controls xenobiotic detoxification via induction of cytochrome P450 1A1 (CYP1A1) and regulates immune responses in the intestine.
Christopher Manzella, Megha Singhal, Waddah A. Alrefai, Seema Saksena, Pradeep K. Dudeja, Ravinder K. Gill   +5 more
doaj   +1 more source

Factors Associated With Long‐Term Survivors With Epidermal Growth Factor Receptor Positive Non‐Small Cell Lung Cancer Treated With First or Second‐Generation Tyrosine Kinase Inhibitors: A Canadian Multi‐Center Cohort

Asia-Pacific Journal of Clinical Oncology, EarlyView.
In a multi‐center Canadian cohort of 577 patients with advanced epidermal growth factor receptor‐mutated non‐small cell lung cancer treated with first/second‐generation TKIs, Asian ancestry and female sex predicted longer survival, while the L858R mutation predicted shorter survival.
Heather Halperin, Amanda J. W. Gibson, Ali Hussein, Mike Sung, Pascale Tomasini, Michelle Dean, Jennifer H. Law, Cheryl Ho, Vishal Navani, Natasha B. Leighl, Desiree Hao   +10 more
wiley   +1 more source