Results 71 to 80 of about 34,953 (257)

Application of the CRISPR Cas-9 technique to obtain a hepatic bovine in vitro model (BFH12) deleted of the CYP1A1 and CYP3A28 genes

, 2022
reservedBovine is one of the most relevant veterinary species and one of the most essential sources of food in the industrialized world. Being cattle one of the most prevalent species in the food sector -used for meat products, milk and cheese- interest ...
D'ONOFRIO, CATERINA
core  

Novel Pathways of Ponatinib Disposition Catalyzed By CYP1A1 Involving Generation of Potentially Toxic Metabolites

Journal of Pharmacology and Experimental Therapeutics, 2017
Ponatinib, a pan-BCR-ABL tyrosine kinase inhibitor for the treatment of chronic myeloid leukemia (CML), causes severe side effects including vascular occlusions, pancreatitis, and liver toxicity, although the underlying mechanisms remain unclear ...
D. Lin, Rumen V. Kostov, J. Huang, C. Henderson, C. Wolf   +4 more
semanticscholar   +1 more source

Bisphenol A and Its Analogs: Toxicity Analysis in Mouse and Rat Liver—A Review

Journal of Applied Toxicology, EarlyView.
ABSTRACT Bisphenol A (BPA) and its analogs are widely recognized for their use in industry and plastic manufacturing. Consequently, humans and animals are continually exposed to various substances in their daily lives. This review evaluates the hepatic toxicity of BPA and its analogs in mice and rats, with particular emphasis on molecular mechanisms ...
Sevda Bagdatli, Muhammed Canik, Gizem Gencay, Nurbanu Zengin, Tarık Dinc, Nazan Deniz Yön   +5 more
wiley   +1 more source

Effect of Glutathione S‐Transferase and Metallothionein Polymorphisms on Mercury Levels and End‐Stage Renal Disease (ESRD) in Colombian Patients

Environmental Toxicology, EarlyView.
ABSTRACT Epidemiological studies have demonstrated a link between chronic kidney disease (CKD) and environmental mercury (Hg) exposure. Colombia has a well‐documented history of artisanal and small‐scale gold mining, where Hg exposure affects miners and nearby riverside and urban populations. This study aimed to evaluate the effects of polymorphisms in
Diana M. Narváez, Juliana Lago, Carlos Trillos, Marcela Varona, Leonardo Briceño, Ruth Marien Palma, Sonia M. Díaz, Gilma Hernández, Eliana M. Téllez, Juan Sebastián Aguilar, Daniela Castellanos, Xavier Martínez, Estefanía Zapata, Alix Rocio Barrios, Ignacio Villanueva, Michael R. Fonseca, Helena Groot   +16 more
wiley   +1 more source

Synergistic Association of CYP1A1 Polymorphisms with Increased Susceptibility to Squamous Cell Lung Cancer in North Indian Smokers

The International Journal of Biological Markers, 2016
Objectives Studies in different populations have shown that polymorphisms within the CYP1A1 gene play an important role in determining individual susceptibility to lung cancer.
Yashila Girdhar, Navneet Singh, Digambar Behera, Siddharth Sharma PhD   +3 more
doaj   +1 more source

Skatole (3-Methylindole) Is a Partial Aryl Hydrocarbon Receptor Agonist and Induces CYP1A1/2 and CYP1B1 Expression in Primary Human Hepatocytes

PLoS ONE, 2016
Skatole (3-methylindole) is a product of bacterial fermentation of tryptophan in the intestine. A significant amount of skatole can also be inhaled during cigarette smoking.
M. K. Rasmussen, P. Balaguer, B. Ekstrand, Martine Daujat-Chavanieu, Sabine Gerbal-Chaloin   +4 more
semanticscholar   +1 more source

Kaempferol Protects Intestinal Health in Chinese Forest Musk Deer Possibly by Regulating Intestinal Microbiota and Inhibiting the NF‐κB/NLRP3 Signaling Pathway

Integrative Zoology, EarlyView.
Kaempferol modulates the tryptophan metabolism pathway by increasing the abundances of Christensenellaceae R7 group, Bacteroides, and Blautia and reducing that of Rikenellaceae RC9 gut group, thereby significantly increasing the levels of ILA and IAA. This process inhibits the activation of NF‐κB/NLRP3 signaling pathway, reduces pro‐inflammatory factor
Xiangyu Liu, Zhanjun Ren, Xiuzhu Sun, Shuhui Wang   +3 more
wiley   +1 more source

TLR2 Controls Intestinal Carcinogen Detoxication by CYP1A1

PLoS ONE, 2012
Intestinal cytochrome P450 subclass 1A1 (CYP1A1) contributes to a metabolic "shield" protecting the host from ingested carcinogens such as polycyclic aromatic hydrocarbons (PAH). The expression of CYP1 (including CYP1A2 and CYP1B1) is considered to depend solely on a heterodimeric transcription factor consisting of the arylhydrocarbon receptor (AHR ...
Do, Khoa Nguyen, Fink, Lisbeth Nielsen, Jensen, Thomas Elbenhardt, Gautier, Laurent, Parlesak, Alexandr   +4 more
openaire   +6 more sources

CYP1A1 gene polymorphism and risk of epithelial ovarian neoplasm

, 2002
Objective. Gene-environment interactions have been the focus of a number of recent studies of the occurrence of human cancers, and an association between the risk and the CYP1A1*3 polymorphism has been noticed for several cancers.
Aktas, D, Guney, I, Yuce, K, Tuncbilek, E, Alikasifoglu, M, Ayhan, A   +5 more
core   +1 more source

Functional role and tobacco smoking effects on methylation of CYP1A1 gene in prostate cancer

OncoTarget, 2016
Cytochrome P450 (CYP) 1A1 is a phase I enzyme that can activate various compounds into reactive forms and thus, may contribute to carcinogenesis. In this study, we investigated the expression, methylation status, and functional role of CYP1A1 on prostate
Yozo Mitsui, I. Chang, Taku Kato, Yutaka Hashimoto, S. Yamamura, S. Fukuhara, Darryn K. Wong, Marisa Shiina, Mitsuho Imai-Sumida, S. Majid, Sharanjot Saini, H. Shiina, K. Nakajima, G. Deng, R. Dahiya, Yuichiro Tanaka   +15 more
semanticscholar   +1 more source