Results 81 to 90 of about 15,644 (193)

Cytochrome P450 1a (CYP1A)‐Knockout Javanese Medaka Fish Exhibit Diabetic Traits and Reduced Reproductive Capacity

The FASEB Journal, Volume 40, Issue 12, 30 June 2026.
Analyses of cytochrome P450 1a (CYP1A)‐knockout (KO) Javanese medaka (Oryzias javanicus) revealed that CYP1A is involved in glucose regulation and reproduction. In the KO fish, significant increases in hepatic transcripts of insulin, glucagon, and somatostatin genes, as well as elevated blood glucose, liver mass, and liver triglyceride levels ...
Suhaila Rusni, Yuki Yoshioka, Hilda Mardiana Pratiwi, Toshiyuki Takagi, Muhammad Rahmad Royan, Yuya Hojo, Seiichi Uno, Shinji Kanda, Yusuke Takehana, Masato Kinoshita, Koji Inoue   +10 more
wiley   +1 more source

Synthesis of Aromatic Aldehydes by CH Formylation of Aromatics with Silyl Formates Prepared from CO2 and Hydrosilanes

Advanced Synthesis &Catalysis, Volume 368, Issue 12, 17 June 2026.
A new method has been developed for the C–H formylation of aromatic compounds using silyl formates synthesized from CO2 and hydrosilanes. This is the first report on the direct C–H formylation of aromatics with silyl formates. The formylation reactions were promoted by BBr3 or BCl3. The reaction mechanism has been clarified by DFT calculations. Despite
Natsumi Nitta, Kei Hirokawa, So Saibara, Bikash Dev Nath, Kazuto Takaishi, Tadashi Ema   +5 more
wiley   +1 more source

A Modeling Investigation of the CYP1A Drug Interactions of Riluzole

Clinical and Translational Science
Cytochrome‐P‐450 (CYP)1A2 has been considered the major enzyme metabolizing riluzole since its approval. However, the inhibitor that was used in the original experiments, α‐naphthoflavone, is also a potent inhibitor of CYP1A1.
Paul Malik, Paola Mian, Jinsy Andrews, Matthew Rosebraugh, Senda Ajroud‐Driss   +4 more
doaj   +1 more source

CYP1A1 Gene and GSTM1 Gene Polymorphism and the Combined Effects and Risk of Lung Cancer: A meta-analysis

Chinese Journal of Lung Cancer, 2011
Background and objective Cytochrome P450A1 (CYP1A1) gene and glutathione S-transferase M1 (GSTM1) gene both have single nucleotide polymorphisms and effects on lung cancer. Currently, however, the risk of lung cancer due to the CYP1A1 and GSTM1 genes has
Cheng LI, Zhihua YIN, Baosen ZHOU
doaj   +1 more source

Novel Nonsynonymous Polymorphisms of the CYP1A1 Gene in Japanese

Drug Metabolism and Pharmacokinetics, 2003
We found five novel nonsynonymous polymorphisms of the human CYP1A1 gene from Japanese individuals. The five single nucleotide polymorphisms (SNP) in exon 7 (2346_2347 ins T, 2414T>A, 2461C>T, 2500C>T and 2546C>G causing premature stop codon, Ile(448)Asn, Arg(464)Cys, and Arg(477)Trp and Pro(492)Arg, respectively) were as follows:SNP, 030212Saito001 ...
SAITO, Tetsuya, EGASHIRA, Mari, KIYOTANI, Kazuma, FUJIEDA, Masaki, YAMAZAKI, Hiroshi, KIYOHARA, Chikako, KUNITOH, Hideo, KAMATAKI, Tetsuya   +7 more
openaire   +2 more sources

RETRACTED ARTICLE: In silico analysis of human CYP1A1 protein and microplastics interaction

Discover Chemistry
Microplastics (MPs) are ubiquitous environmental pollutants, raising significant concerns about their potential impacts on human health. Cytochrome P450 1A1 (CYP1A1) plays a crucial role in the biotransformation and detoxification of xenobiotics ...
Faijunnesa Rashid, Mustafizur Rahman, Mukul Chandra Sarker, Israt Jahan Tonny, Md. Arman Khan, Muhammad Ataullah   +5 more
doaj   +1 more source

CYP1A1 Variability In Human Populations

Collegium antropologicum, 2019
The human cytochrome P4501A1 (CYP1A1) enzyme plays an important role in the metabolism of xenobiotics and endogenous substrates. Because polymorphisms within the CYP1A1 gene have been shown to be associated with various cancer risks and with the predicting clinical efficacy of some chemotherapies in different populations, most studies focus on their ...
Martinez-Labarga C., Scano G., Lelli R., Peacock B., Ricci L., Primativo G., Contini I., Biondi G., Crawford M. H., Hafez H. S., Novelletto A., Rudan P., De Stefano G., Rickards O.   +13 more
openaire   +2 more sources

Chk2 deletion rescues bone loss and cellular senescence induced by Bmi1 deficiency via regulation of Cyp1a1

Journal of Orthopaedic Translation
Background/objective: Bone homeostasis, maintained by a balance between osteoblastic bone formation and osteoclastic bone resorption, is disrupted in osteoporosis, leading to reduced bone mass and increased fracture risk.
Yining Liu, Xiaolei Ji, Jinge Zhang, Jinhong Lu, Boyang Liu, Haijian Sun, Dengshun Miao   +6 more
doaj   +1 more source

The Association of CYP1A1 rs1048943 Polymorphism

The International Journal of Comprehensive Health, Medicine, & Dentistry
Breast cancer remains the most prevalent malignancy in women worldwide and its etiology involves genetic and environmental components. Among these genetic components, the CYP1A1 rs1048943 (Ile462Val) polymorphism has been shown to play a modifying role in breast cancer susceptibility based on its contribution to the metabolism of carcinogens and ...
openaire   +1 more source

Fulvic acid exhibits antitumor effects in ovarian cancer cells by upregulating cytochrome P450 family 1 subfamily A member 1 expression

Discover Oncology
Objective Fulvic acid (FA), a humic substance, has various applications in agricultural (animal husbandry) and pharmaceutical industries. However, to the best of our knowledge, its antitumor effects remain unclear.
Min Chen, Ming Cheng, Chenchen Shao, Wenwen Liang, Yi Tang, Fangjun Ding   +5 more
doaj   +1 more source