Results 81 to 90 of about 34,953 (257)

Factors Associated With Long‐Term Survivors With Epidermal Growth Factor Receptor Positive Non‐Small Cell Lung Cancer Treated With First or Second‐Generation Tyrosine Kinase Inhibitors: A Canadian Multi‐Center Cohort

Asia-Pacific Journal of Clinical Oncology, EarlyView.
In a multi‐center Canadian cohort of 577 patients with advanced epidermal growth factor receptor‐mutated non‐small cell lung cancer treated with first/second‐generation TKIs, Asian ancestry and female sex predicted longer survival, while the L858R mutation predicted shorter survival.
Heather Halperin, Amanda J. W. Gibson, Ali Hussein, Mike Sung, Pascale Tomasini, Michelle Dean, Jennifer H. Law, Cheryl Ho, Vishal Navani, Natasha B. Leighl, Desiree Hao   +10 more
wiley   +1 more source

A comprehensive meta-analysis and a case–control study give insights into genetic susceptibility of lung cancer and subgroups

Scientific Reports, 2021
Reports of genetic association of polymorphisms with lung cancer in the Indian subcontinent are often conflicting. To summarise and replicate published evidence for association with lung cancer and its subgroups. We performed a meta-analysis of candidate
Debmalya Sengupta, Souradeep Banerjee, Pramiti Mukhopadhyay, Ritabrata Mitra, Tamohan Chaudhuri, Abhijit Sarkar, Gautam Bhattacharjee, Somsubhra Nath, Susanta Roychoudhury, Samsiddhi Bhattacharjee, Mainak Sengupta   +10 more
doaj   +1 more source

Daytime Restricted Feeding Modifies the Temporal Expression of CYP1A1 and Attenuated Damage Induced by Benzo[a]pyrene in Rat Liver When Administered before CYP1A1 Acrophase

Toxics, 2021
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that heterodimerizes with the AhR nuclear translocator (ARNT) to modulate CYP1A1 expression, a gene involved in the biotransformation of benzo[a]pyrene (BaP).
Oscar Samuel Ávila-Rosales, Mauricio Díaz-Muñoz, Rafael Camacho-Carranza, Elvia Coballase-Urrutia, José Pedraza-Chaverri, Jorge Omar García-Rebollar, Jesús Javier Espinosa-Aguirre   +6 more
doaj   +1 more source

Pulmonary Inflammation Impacts on CYP1A1-Mediated Respiratory Tract DNA Damage Induced by the Carcinogenic Air Pollutant Benzo[a]pyrene

Toxicological Sciences, 2015
Pulmonary inflammation can contribute to the development of lung cancer in humans. We investigated whether pulmonary inflammation alters the genotoxicity of polycyclic aromatic hydrocarbons (PAHs) in the lungs of mice and what mechanisms are involved. To
V. M. Arlt, A. Krais, R. Godschalk, Y. Riffo-Vasquez, Iveta Mrízová, C. Roufosse, C. Corbin, Q. Shi, E. Frei, M. Stiborová, F. V. van Schooten, D. Phillips, D. Spina   +12 more
semanticscholar   +1 more source

3‐Indoxyl Sulfate and O‐Acetylcarnitine Are Potential Novel Biomarkers for Early Diagnosis of Esophageal Cancer

Cancer Science, EarlyView.
Through comprehensive analysis of plasma and urine from patients with esophageal cancer and healthy controls, 3‐indoxyl sulfate and O‐acetylcarnitine were identified as metabolites significantly associated with esophageal cancer. These metabolites were elevated in patients and demonstrated promising diagnostic performance for early detection.
Kenji Hamada, Yohei Ozawa, Hiroshi Okamoto, Shinji Fukuda, Tomoyoshi Soga, Takaaki Abe, Hozumi Motohashi, Shohei Murakami, Takashi Kamei   +8 more
wiley   +1 more source

Association between cytochrome P450 1A1 (CYP1A1) gene polymorphisms and the risk of renal cell carcinoma: a meta-analysis

Scientific Reports, 2015
Cytochrome P450 1A1 (CYP1A1) usually metabolizes carcinogens to their inactive derivatives but occasionally converts the chemicals to more potent carcinogens.
Fan-Dong Meng, Ping Ma, Cheng-Guang Sui, Xin Tian, You-Hong Jiang   +4 more
semanticscholar   +1 more source

Bakuchiol: From structural mimicry to systems‐level skin biology

International Journal of Cosmetic Science, EarlyView.
Convergent outcomes, divergent mechanisms: bakuchiol vs. retinol. Bakuchiol exhibits functional convergence with retinol in improving extracellular matrix integrity, epidermal differentiation and barrier function, while operating through distinct mechanisms.
Ratan K. Chaudhuri
wiley   +1 more source

CYP1A1 and Cnr nitroreductase bioactivated niclosamide in vitro [PDF]

Mutagenesis, 2013
Abstract Niclosamide produces genotoxic effects, such as point mutations in Salmonella sp., sperm-head abnormalities in mice and clastogenic effects in human lymphocytes in vitro and in vivo. As cytochrome P450 could be involved in the bioactivation of niclosamide, we investigated which subfamily was involved.
Evelyn, Beristain-Castillo, Mariano, Martínez-Vázquez, Rafael, Camacho-Carranza, Javier J, Espinosa-Aguirre   +3 more
openaire   +2 more sources

Trans‐resveratrol alleviates inflammation and improves skin barrier function via aryl hydrocarbon receptor pathway in human reconstructed epidermis

International Journal of Cosmetic Science, EarlyView.
In a cytokine‐challenged human epidermal model, trans‐resveratrol reduces inflammation (IL‐1α) and oxidative stress markers (CYP1A1, CYP1B1), while modulating the expression of barrier‐related genes (LOR, OCLN) and differentiation‐associated CASP14. This supports its role as a multifunctional active for sensitive and compromised skin.
Irini M. Dijkhoff, Sandeep Keshavan, Regina G. Daré, Alke Petri‐Fink, Marc Eeman, Agnès Tessier, Barbara Rothen‐Rutishauser   +6 more
wiley   +1 more source

CYP1A1, Cigarette Smoking, and Colon and Rectal Cancer [PDF]

American Journal of Epidemiology, 2004
Cytochrome P-450 (CYP) is involved in the activation and metabolism of polycyclic aromatic hydrocarbons in tobacco products. The authors evaluated the association of two polymorphisms in the CYP1A1 gene--the noncoding Msp I polymorphism in the 3'-untranslated region and the Ile462Val polymorphism in exon 7--with colon and rectal cancer.
Martha L, Slattery, W, Samowtiz, K, Ma, M, Murtaugh, C, Sweeney, T R, Levin, S, Neuhausen   +6 more
openaire   +2 more sources