Results 101 to 110 of about 34,953 (257)
Biochemical characterization of variants of canine CYP1A1 using heterologous expression
, 2017 Cytochrome P450 1A1 (CYP1A1) is a heme-containing mono-oxygenase involved in metabolism of environmental contaminants. Two variants of dog CYP1A1 with a single residue difference were identified and designated Sap1 and Sap2.
S H Lee +15 more
core +1 more source
Pharmacogenomics of dolutegravir: A scoping review of evidence, gaps and clinical implications
British Journal of Clinical Pharmacology, Volume 92, Issue 11, Page 3716-3732, November 2026.Dolutegravir underpins modern first‐ and second‐line HIV treatment regimens; however, interindividual variability in its disposition and tolerability presents challenges for optimal use. This scoping review mapped current evidence on the pharmacogenomics of dolutegravir, focusing on pharmacokinetics and pharmacodynamics, and methodological limitations ...
Ronald Kiguba +2 more
wiley +1 more source
Cytosolic persistence of mouse brain CYP1A1 in chronic heme deficiency [PDF]
, 2017 Previous work has demonstrated that the function of extrahepatic cytochrome P450 CYP1A1 is dependent on the availability of heme. CYP1A1 is involved in the activation of polyaromatic hydrocarbons.
Lindberg, Raija L.P. +3 more
core
Protective role of CYP1A1*2A in the development of multiple myeloma
, 2008 We had previously reported the association of the NQO1*2/*2 polymorphism with a decreased risk for multiple myeloma (MM) in Koreans (odds ratio, OR, 0.24; 95% confidence interval, CI, 0.01-0.68).
Lee, Dong Soon +9 more
core +1 more source
Furanoflavones pongapin and lanceolatin B blocks the cell cycle and induce senescence in CYP1A1-overexpressing breast cancer cells [PDF]
, 2018 © 2018 Elsevier Ltd Expression of cytochrome P450-1A1 (CYP1A1) is suppressed under physiologic conditions but is induced (a) by polycyclic aromatic hydrocarbons (PAHs) which can be metabolized by CYP1A1 to carcinogens, and (b) in majority of breast ...
Bharate, Sandip B. +5 more
core +1 more source
Journal of Pharmacy and Bioallied SciencesBackground: Genetic polymorphisms are common and contribute significantly to human illnesses. Aim: This study was carried out to evaluate the importance of genetic variations in the genes expressing cancer-metabolizing enzymes (CYP1A1 and GSTM1) in ...
Devina Pradhan +6 more
doaj +1 more source
Antioxidants, 2020 Benzo[a]pyrene (BaP), a major environmental pollutant, activates aryl hydrocarbon receptor (AHR), induces its cytoplasmic-to-nuclear translocation and upregulates the production of cytochrome P450 1A1 (CYP1A1), a xenobiotic metabolizing enzyme which ...
Yuka Tanaka +3 more
doaj +1 more source
Archives of Toxicology, 2014 The tumour suppressor gene TP53 is mutated in more than 50 % of human tumours, making it one of the most important cancer genes. We have investigated the role of TP53 in cytochrome P450 (CYP)-mediated metabolic activation of three polycyclic aromatic ...
Laura E. Wohak +7 more
semanticscholar +1 more source
Chemistry–Methods, Volume 6, Issue 11, November 2026.Formation of H2 and O2 directly from water by Synechocystis with photosystem II. Under anaerobic conditions, a fraction of the photosynthetically derived electrons can be directed toward H2 evolution. Pseudomonas serves as the primary O2 sink by consuming O2 through citrate supported respiration. This interaction maintains anaerobic conditions required
Kang Lyu +4 more
wiley +1 more source
, 2011 Background: Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy. The U.S. Surveillance Epidemiology and End Results (SEER) registry reports that Hispanic children have the highest incidence of ALL, however, it is unclear if this is
Ryan M. Swinney +6 more
core +1 more source