Results 101 to 110 of about 1,002 (150)

Study of the correlation between CYP1A1 gene promoter methylation and smoking in gastric cancer patients

Fiyz̤, 2019
Background: Gastric cancer is one of the main causes of cancer related deaths particularly in northern parts of Iran. It has been recently attributed to the increased application of agricultural pesticides in these areas.
Leili Sadeghi-Amiri , Ali Barzegar , Novin Nikbakhsh-Zati, Pooyan Mehraban   +3 more
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CYP1A1 wt Allele [PDF]

, 2020
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CYP1A1*2 and CYP1A1*3 Polymorphisms cosegregate in the Indian Population

Anthropologischer Anzeiger, 2002
Several ethnic groups have been genotyped for polymorphisms at the CYP1A1 gene locus that encodes the enzyme that catalyzes the initial step in the metabolism of polycyclic aromatic hydrocarbons. Two of the CYP1A1 polymorphisms, namely, CYP1A1*2 and CYP1A1*3 are reported to cosegregate among the Japanese and to a lesser extent in Caucasians, but not in
Aparna, Kotekar, Rajani, Bhisey
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Human CYP1A1 inhibition by flavonoids

Toxicology in Vitro, 2020
Cytochrome P4501A1 (CYP1A1) is involved in the metabolism of several genotoxic/carcinogenic environmental xenobiotics including polycyclic aromatic hydrocarbons (PAHs) like benzo[a]pyrene. Several authors had proposed CYP1A inhibition as a plausible strategy for cancer chemoprevention.
Rebeca, Santes-Palacios, Ana L, Marroquín-Pérez, Sandra L, Hernández-Ojeda, Rafael, Camacho-Carranza, Tzipe, Govezensky, J Javier, Espinosa-Aguirre   +5 more
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Dietary Ellagic Acid Inhibits the Enzymatic Activity of CYP1A1 without Altering Hepatic Concentrations of CYP1A1 or CYP1A1 mRNA

Biochemical and Biophysical Research Communications, 1994
The anticarcinogen ellagic acid significantly reduces the incidence of polycyclic aromatic hydrocarbon induced carcinomas, in association with significant reductions in benzo[a]pyrene hydroxylase activity and CO reducible hepatic cytochrome P450. This suggested that ellagic acid reduced hepatic concentrations of CYP1A1, but these changes occurred ...
D H, Barch, L M, Rundhaugen, P E, Thomas, P, Kardos, N S, Pillay   +4 more
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CYP1A1, smoking and venous thromboembolism

Thrombosis and Haemostasis, 2010
SummarySince CYP1A1 enzyme is involved in metabolism of tobacco carcinogens, the CYP1A1 gene may be of relevance to smoking-induced differences in the risks of venous thromboembolism (VTE). We conducted a case-control study to investigate genetic polymorphisms in CYP1A1 that might modify the risk of developing VTE.
Jin, Zhu, Wen-Jie, Zheng, Fan-Cui, Kong, Wei-Juan, Zhang, He-Yao, Wang, Chen, Wang   +5 more
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The CYP1A1 gene and cancer susceptibility

Critical Reviews in Oncology/Hematology, 1993
A close correlation between cigarette smoking associated lung cancer incidence and an Msp I restriction fragment length polymorphism (RFLP) of the human P-450 1A1 (CYP1A1) gene was found in a Japanese population in terms of genotype frequency and cigarette dose.
K, Kawajiri, K, Nakachi, K, Imai, J, Watanabe, S, Hayashi   +4 more
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Effect of troglitazone on CYP1A1 induction

Toxicology, 2008
Several peroxisome proliferators enhance CYP1A1 activity, but the mechanisms involved in this enhancement remain unknown. In this study, we examined the effect of troglitazone, a peroxisome proliferator-activated receptor-gamma (PPAR-gamma) agonist, on CYP1A1 gene expression and explored the mechanisms involved in these effects.
Hyung Gyun, Kim, Eun Hee, Han, Hye Gwang, Jeong   +2 more
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Regulation of CYP1A1 expression

The FASEB Journal, 1992
CYP1A1 is considered to be involved mainly in oxidative metabolism of exogenous chemicals and drugs. Synthesis of this hemoprotein is induced in livers, lungs, and other tissues of experimental animals by the administration of these chemicals.
Y, Fujii-Kuriyama, H, Imataka, K, Sogawa, K, Yasumoto, Y, Kikuchi   +4 more
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Variation in induced CYP1A1 levels: relationship to CYP1A1, Ah receptor and GSTM1 polymorphisms

Pharmacogenetics, 2000
The genotypic basis of interindividual variation in levels of induced CYP1A1 activity has been investigated by screening both the CYP1A1 gene and the Ah receptor gene (AhR) for both previously described and novel polymorphisms. A 103-fold level of interindividual variation in induced CYPlA1 activity [ethoxyresorufin O-deethylase (EROD)] was observed in
J, Smart, A K, Daly
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