Smokeless Tobacco‐Associated Nitrosamines Impact on Aryl Hydrocarbon Receptor: In Silico and In Vitro Study [PDF]
Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 11, November 2026.Schematic representation of STE (smokeless tobacco extract) impact on AhR and AhR‐related genes. TSNAs present in STE induce AhR that results in to AhR conformational changes and translocation to the nucleus. Inside the nucleus, AhR heterodimerizes with Arnt and binds to XRE region of genome.
Mohammad Sajid +5 more
wiley +2 more sources
Integrated machine learning and multi-omics analysis identifies CYP1B1 as a candidate target of orientin in intervertebral disc degeneration-associated low back pain [PDF]
Frontiers in Pain ResearchObjectivesOrientin is a bioactive agent isolated from natural resources successfully applied for pain control. This study was to explore candidate hub gene of orientin to intervertebral disc degeneration (IDD) -associated low back pain.MethodsThis study ...
Hai-E Liu +3 more
doaj +2 more sources
Upregulation of CYP1B1-AS1 correlates with aggressive phenotypes and poor prognosis in thyroid cancer [PDF]
World Journal of Surgical OncologyBackground Aberrant expression of lncRNA CYP1B1-AS1 drives the pathogenesis of diverse cancers, with thyroid carcinoma (TC) being no exception. Aim This study was designed to clarify how CYP1B1-AS1 expression impacts prognostic outcomes in TC patients ...
Xun Li +4 more
doaj +2 more sources
Gut Microbiota‐Dependent Tryptophan Metabolism Drives the Therapeutic Effects of Baitouweng Tang in Colitis via the AhR Pathway [PDF]
Food Science &Nutrition, Volume 14, Issue 10, October 2026.Baitouweng Tang alleviates colitis symptoms in mice by regulating the structure and diversity of gut microbiota, increasing the content of gut microbiota‐related tryptophan metabolites, activating AhR, inhibiting the release of inflammatory mediators, and improving intestinal homeostasis.
Chun Niu +6 more
wiley +2 more sources
CYP1B1 is a potential target of kaempferol in renal fibrosis: a multi‑omics and single‑cell transcriptomics study [PDF]
Bioresources and BioprocessingBackground Renal fibrosis (RF) is a progressive and irreversible pathological process for which effective treatments are limited. This study explores the molecular targets and mechanisms through which kaempferol (Kae) ameliorates RF, with particular ...
Chenjie Huang, Xueli Shi, Ziyou Yan
doaj +2 more sources
Tissue-specific variability in protein expression of cytochrome P450 and glutathione S-transferase isoenzymes in non-small cell lung carcinoma [PDF]
Arhiv za Higijenu Rada i ToksikologijuEarlier tissue-based studies report heterogeneous CYP and GST protein expression in non-small cell lung cancer (NSCLC), but simultaneous assessment of phase I and II enzymes in paired tumour and peripheral normal tissues remains limited and their ...
Kılıç Murat +6 more
doaj +2 more sources
Protective Effects of Chia Seeds and Vitamin E Against Benzo[a]Pyrene‐Induced Toxicity in Male Mice: A Comparison of co‐Administration and Pre‐Treatment Strategies [PDF]
Food Science &Nutrition, Volume 14, Issue 10, October 2026.Benzo[a]pyrene (BaP), a polycyclic aromatic hydrocarbon found in tobacco smoke and grilled foods, induces DNA damage, oxidative stress, liver toxicity, and lipid metabolism disturbances. This study investigated the protective effects of chia seeds (10%, 20%, and 30% in the diet) and vitamin E (250 mg/kg) against BaP‐induced toxicity (20 mg/kg) in male ...
Mohammad Rezaei +1 more
wiley +2 more sources
CYP1B1- and CYP1A1-Template systems and their application to metabolism and inhibition [PDF]
Genes and EnvironmentPrediction of cytochrome P450 (CYP)-mediated metabolism is crucial for assessing the safety of chemicals. An in silico system to reproduce CYP1B1-mediated reactions has been developed by the reverse construction of ligand-accessible spaces from ligand ...
Yasushi Yamazoe +4 more
doaj +2 more sources
The role of CYP1B1 in oral squamous cell carcinoma: a systematic review and meta-analysis [PDF]
World Cancer Research Journal, 2023 Objective: CYP1B1 is crucial for the metabolism of tobacco-derived procarcinogens to reactive metabolites which is known to play a major role in the pathogenesis of oral squamous cell carcinoma (OSCC).
A. Bartake +5 more
doaj +1 more source
CYP1B1 Enhances Cell Proliferation and Metastasis through Induction of EMT and Activation of Wnt/β-Catenin Signaling via Sp1 Upregulation. [PDF]
PLoS ONE, 2016 Cytochrome P450 1B1 (CYP1B1) is a major E2 hydroxylase involved in the metabolism of potential carcinogens. CYP1B1 expression has been reported to be higher in tumors compared to normal tissues, especially in hormone-related cancers including breast ...
Yeo-Jung Kwon +5 more
doaj +1 more source