Results 21 to 30 of about 13,799 (198)
Frontiers in Cell and Developmental Biology, 2021 Mutations in the cytochrome P450-1B1 (Cyp1b1) gene is a common genetic predisposition associated with various human glaucomas, most prominently in primary congenital glaucoma (PCG).
Naseem Amirmokhtari +6 more
doaj +1 more source
CYP1B1 as a therapeutic target in cardio-oncology [PDF]
Clinical Science, 2020 Abstract Cardiovascular complications have been frequently reported in cancer patients and survivors, mainly because of various cardiotoxic cancer treatments. Despite the known cardiovascular toxic effects of these treatments, they are still clinically used because of their effectiveness as anti-cancer agents.
Alexa N. Carrera +2 more
openaire +2 more sources
CYP1B1 inhibits ferroptosis and induces anti-PD-1 resistance by degrading ACSL4 in colorectal cancer
Cell Death and Disease, 2023 Immune checkpoint blockade (ICB) is a promising treatment strategy for colorectal cancer (CRC) patients. However, most CRC patients do not response well to ICB therapy. Increasing evidence indicates that ferroptosis plays a critical role in immunotherapy.
Congcong Chen +9 more
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Anti-cancer drug interaction with cytochrome P450 CYP1B1. [PDF]
, 2003 One mechanism potentially amenable to chemotherapeutic intervention involves cytochrome P450 CYP1B1. Our research has established the concept of over-expression of individual forms of cytochrome P450 - in particular CYP1B1 - in a range of solid tumours ...
Melvin, William T. +2 more
core +6 more sources
Cytochrome P450 1B1 Overexpression in Cervical Cancers: Cross-sectional Study
Interactive Journal of Medical Research, 2021 BackgroundCurrent standard treatments for patients with recurrent cervical cancer are not very effective and are associated with severe toxicity.
Fatemah O F O Alshammari +4 more
doaj +1 more source
CYP1B1 mRNA inducibility due to benzo(a)pyrene is modified by the CYP1B1 L432V gene polymorphism [PDF]
Mutagenesis, 2014 Benzo(a)pyrene (BaP), a primary component of tobacco smoke, is activated by cytochrome P450 1B1 (CYP1B1). Smokers homozygous for the C-allele (*1/*1) at the CYP1B1 Leu432Val polymorphism have shown increased CYP1B1 expression, compared to smokers homozygous for the G-allele *3/*3.
Simone, Helmig +3 more
openaire +2 more sources
Biology of Sex Differences, 2020 Background Previously, we showed that 6β-hydroxytestosterone (6β-OHT), a cytochrome P450 1B1 (CYP1B1)-derived metabolite of testosterone, contributes to angiotensin II (Ang II)-induced hypertension in male mice.
Ajeeth K. Pingili +5 more
doaj +1 more source
Cytochrome P450 1B1 Is Critical for Neointimal Growth in Wire‐Injured Carotid Artery of Male Mice
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018 Background We have reported that cytochrome P450 1B1 (CYP1B1), expressed in cardiovascular tissues, contributes to angiotensin II–induced vascular smooth muscle cell (VSMC) migration and proliferation and development of hypertension in various ...
Kamalika Mukherjee +7 more
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CYP1B1 gene: Implications in glaucoma and cancer [PDF]
Journal of Cancer, 2020 Glaucoma is a serious disease that can lead to irreversible loss of vision. Patients with primary congenital glaucoma may have elevated intraocular pressure. Hypertension causes damages to intraocular structures and affects the Schlemm's canal, collector channels, trabecular meshwork, and optic nerve's molecular structures.
Alsubait, Arwa +4 more
openaire +2 more sources
Cytochrome P450 1B1 and primary congenital glaucoma
Journal of Ophthalmic & Vision Research, 2015 Cytochrome P450 1B1 (Cyp1b1) belongs to the CYP450 superfamily of heme-binding mono-oxygenases which catalyze oxidation of various endogenous and exogenous substrates.
Yun Zhao +2 more
doaj +1 more source