Results 31 to 40 of about 13,799 (198)
PLoS ONE, 2013 BackgroundThere are unpredictable inter-individual differences in sensitivity to psoralen-UVA (PUVA) photochemotherapy, used to treat skin diseases including psoriasis. Psoralens are metabolised by cytochrome P450 enzymes (P450), and we hypothesised that
Yusuf Y Deeni +4 more
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Redox Biology, 2023 Oxygen supplementation is life saving for premature infants and for COVID-19 patients but can induce long-term pulmonary injury by triggering inflammation, with xenobiotic-metabolizing CYP enzymes playing a critical role.
Sandra L. Grimm +9 more
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Cells, 2023 Cisplatin is one of the most effective chemotherapeutic agents strongly associated with nephrotoxicity. Tubular adult renal progenitor cells (tARPC) can regenerate functional tubules and participate in the repair processes after cisplatin exposition ...
Rossana Franzin +14 more
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Profiling of CYP4Z1 and CYP1B1 expression in bladder cancers [PDF]
Scientific Reports, 2020 Abstract Bladder cancer is the tenth most common cancer worldwide, where its burden remains a challenge and needs new novel therapies. Several reports indicate expression of CYP4Z1 and CYP1B1 in many tumours. Their expressions are associated with a poor prognosis, and therefore proposed as promising biomarkers or ...
Yousef M. Al-saraireh +7 more
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A novel methodology for enhanced and consistent heterologous expression of unmodified human cytochrome P450 1B1 (CYP1B1). [PDF]
PLoS ONE, 2014 Cytochrome P450 1B1 (CYP1B1) is a universal cancer marker and is implicated in many other disorders. Mutations in CYP1B1 are also associated with childhood blindness due to primary congenital glaucoma (PCG).
Muneeb A Faiq +4 more
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Cytochrome P450 1B1: A Key Regulator of Ocular Iron Homeostasis and Oxidative Stress
Cells, 2022 Cytochrome P450 (CYP) 1B1 belongs to the superfamily of heme-containing monooxygenases. Unlike other CYP enzymes, which are highly expressed in the liver, CYP1B1 is predominantly found in extrahepatic tissues, such as the brain, and ocular tissues ...
Yong-Seok Song +5 more
doaj +1 more source
Stem Cells International, 2016 7,12-Dimethylbenz(a)anthracene (DMBA) rapidly suppresses hematopoietic progenitors, measured as colony forming units (CFU), in mouse bone marrow (BM) leading to mature cell losses as replenishment fails.
Catherine M. Rondelli +4 more
doaj +1 more source
Fluids and Barriers of the CNS, 2011 Background AhR activates the transcription of several target genes including CYP1B1. Recently, we showed CYP1B1 as the major cytochrome P450 (CYP) enzyme expressed in human brain microvessels.
Jacob Aude +7 more
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Comparative Computational Studies on Selective CytochromeP450 1B1 Inhibitors [PDF]
International Journal Bioautomation, 2020 Selective inhibitors of CYP isoforms gaining importance in the treatment of cancers caused by hormonal imbalance. Metabolites of estradiol and polyaromatic hydrocarbons generated due to CYP1B1 activity were reported to be oncogenic.
Mohd Usman Mohd Siddique +3 more
doaj +1 more source
Primary congenital glaucoma and the involvement of CYP1B1
Middle East African Journal of Ophthalmology, 2011 Primary congenital glaucoma (PCG) is an autosomal recessive disorder in children due to the abnormal development of the trabecular meshwork and the anterior chamber angle. With an onset at birth to early infancy, PCG is highly prevalent in inbred populations and consanguinity is strongly associated with the disease.
Kaur, Kiranpreet +2 more
openaire +3 more sources