Results 41 to 50 of about 13,799 (198)
Cyp1b1 -/- LSEC are more migratory.
, 2018 (A) Confluent monolayers of Cyp1b1+/+ and Cyp1b1-/- LSEC were wounded and wound closure was monitored and photographed for 72 h. Please note that a significant area of wound remained uncovered in Cyp1b1+/+ LSEC, while Cyp1b1-/- cells migrated and covered
Juliana Falero-Perez (5905103) +5 more
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Characterization of a Transgenic Mouse for Human Cytochrome P450 1B1 (CYP1B1) [PDF]
Cytochrome P450 1B1 (Cyp1B1) is a xenobiotic metabolizing enzyme, responsible for polycyclic aromatic hydrocarbon (PAH) oxidative metabolism. CYP1B1 metabolically activates several species of environmentally relevant procarcinogenic PAHs to reactive ...
You, Hyekyoung Hannah
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The genetics associated with Primary Congenital Glaucoma
Advancements in Life Sciences, 2020 Glaucoma is a progressive optic neuropathy; increased intraocular pressure (IOP) is a modifiable risk factor for primary congenital glaucoma (PCG). Increase IOP causes retinal and optic nerve compression and leads to gradual and irreversible loss of ...
Ali Imran +6 more
doaj
Cyp1b1 -/- LSEC are less adherent to ECM proteins.
, 2018 (A) The adhesion of Cyp1b1+/+ and Cyp1b1 -/- cells to various ECM proteins including fibronectin, vitronectin, collagen I and Collagen IV was determined as detailed in Methods.
Juliana Falero-Perez (5905103) +5 more
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PLoS ONE, 2020 Astrocytes (AC) are the most abundant cells in the central nervous system. In the retina, astrocytes play important roles in the development and integrity of the retinal neurovasculature. Astrocytes dysfunction contributes to pathogenesis of a variety of
Juliana Falero-Perez +2 more
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Lipidomics Reveals a Link between CYP1B1 and SCD1 in Promoting Obesity
, 2015 Cytochrome P450 1B1 (CYP1B1) is involved in the metabolism of xenobiotic compounds and endogenous metabolites. Disruption of Cyp1b1 in mice results in suppression of high-fat diet (HFD)-induced obesity and an extensive change in hepatic energy regulation
Ting Wang (16292) +7 more
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Development of an In Vitro Model to Screen CYP1B1-Targeted Anticancer Prodrugs [PDF]
, 2016 This article has been accepted for publication in the Journal of Biomolecular Screening.Cytochrome P450 1B1 (CYP1B1) is an anticancer therapeutic target due to its overexpression in a number of steroid hormone–related cancers.
Wang, Zhiying +4 more
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Advanced Science, EarlyView.Guided by pharmacophore modeling and molecular docking, aryl hydrocarbon receptor (AHR)‐responsive carbon dots were synthesized. They bind directly to AHR and expand gut‐resident regulatory T (Treg) cells. Treg‐derived C‐C motif chemokine ligand 1 (CCL1) enhances macrophage efferocytosis, creating a pro‐regenetative niche that promotes colonic mucosal ...
Zilu Zhu +6 more
wiley +1 more source
Goniodysgenesis variability and activity of CYP1B1 genotypes in primary congenital glaucoma. [PDF]
PLoS ONE, 2017 Mutations in the CYP1B1 gene are currently the main known genetic cause of primary congenital glaucoma (PCG), a leading cause of blindness in children.
María T García-Antón +9 more
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Российский офтальмологический журнал, 2022 Purpose. Description of a clinical case of a patient with congenital glaucoma and mutations in the CYP1B1 gene, taking into account the analysis of literature data.Material and methods.
L. A. Katargina +4 more
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