Results 61 to 70 of about 13,799 (198)
Journal of Applied Toxicology, Volume 46, Issue 12, Page 4396-4408, December 2026.ABSTRACT Children, as a particularly vulnerable group, are more susceptible to these mutagens due to their developing immune systems, higher physiological vulnerability, and increased exposure through behaviors like outdoor play and hand‐to‐mouth activities. This review aims to investigate the relationship between these environmental exposures, genetic
Thiago Guedes Pinto +7 more
wiley +1 more source
Pharmacogenomics of dolutegravir: A scoping review of evidence, gaps and clinical implications
British Journal of Clinical Pharmacology, Volume 92, Issue 11, Page 3716-3732, November 2026.Dolutegravir underpins modern first‐ and second‐line HIV treatment regimens; however, interindividual variability in its disposition and tolerability presents challenges for optimal use. This scoping review mapped current evidence on the pharmacogenomics of dolutegravir, focusing on pharmacokinetics and pharmacodynamics, and methodological limitations ...
Ronald Kiguba +2 more
wiley +1 more source
Гетерологическая экспрессия, выделение и физико-химические свойства рекомбинантного цитохрома CYP1B1 человека [PDF]
, 2016 In order to study the catalytic properties of CYP1B1 toward a number of steroid compounds, we have developed an effective system of heterologous expression of hemoprotein in E.coli and isolated the preparation of recombinant CYP1B1 «soluble» form in a ...
А. Я. Лущик +7 more
core
CYP1B1 is Polymorphic in Cynomolgus and Rhesus Macaques
Journal of Veterinary Medical Science, 2011 Cytochrome P450 (CYP) 1B1 is involved in the metabolic activation of various procarcinogens, and some CYP1B1 genetic variants alter CYP1B1-dependent procarcinogen metabolism. Cynomolgus and rhesus macaques are frequently used in toxicity tests due to their evolutionary closeness to humans. In this study, we attempted to identify CYP1B1 genetic variants
UNO, Yasuhiro +2 more
openaire +3 more sources
Mitochondrial targeting of mouse NQO1 and CYP1B1 proteins [PDF]
Biochemical and Biophysical Research Communications, 2013 Four dioxin-inducible enzymes--NAD(P)H: quinone oxidoreductase-1 (NQO1) and three cytochromes P450 (CYP1A1, CYP1A2 & CYP1B1)--are implicated in both detoxication and metabolic activation of various endobiotics and xenobiotics. NQO1 is generally regarded as a cytosolic enzyme; whereas CYP1 proteins are located primarily in endoplasmic reticulum (ER ...
Hongbin, Dong +6 more
openaire +2 more sources
Discovery of 2-phenylethyl chromones as potent and selective CYP1B1 inhibitors
Journal of Enzyme Inhibition and Medicinal ChemistryCytochrome P4501B1 (CYP1B1), overexpressed in solid tumours but minimally in healthy tissues, is a promising anticancer target linked to chemoresistance.
Wenming Chen +5 more
doaj +1 more source
Journal of Neurochemistry, Volume 170, Issue 11, November 2026.Using skin fibroblasts from people with Huntington's disease, we compared selective inhibition of the two forms of the protein kinase GSK‐3. Inhibiting either GSK‐3α or GSK‐3β reduced a signaling pathway involved in cell growth and metabolism.
Yarine Lugassy +4 more
wiley +1 more source
CYP1B1 upregulates Sp1 expression.
, 2016 (A-D) Sp1 mRNA levels were measured in MCF-7 cells by (A) RT-PCR following CYP1B1 overexpression, (B) qRT-PCR following CYP1B1 overexpression, (C) RT-PCR following CYP1B1 knockdown, (D) qRT-PCR following CYP1B1 knockdown.
Hyoung-Seok Baek (3178263) +5 more
core +1 more source
Journal of Advanced Research, 2019 The aim of the present study was to evaluate the expression levels of the aryl hydrocarbon receptor (AHR) and its target gene CYP1B1 and to correlate their expression with Wnt5a/b-β-catenin, the CD44+/CD24(−/low) cancer stem cell (CSC) subset and factors
Hossam T. Mohamed +8 more
doaj +1 more source
Cancer Medicine, Volume 15, Issue 10, October 2026.ABSTRACT Spatial heterogeneity in the colorectal cancer (CRC) tumor microenvironment (TME) is closely related to stromal organization and may influence treatment‐related features. In this study, we integrated single‐cell RNA sequencing and spatial transcriptomic data from CRC tissues to examine cancer‐associated fibroblast (CAF)‐dominant spatial ...
Yuan‐jie Liu +5 more
wiley +1 more source