Results 71 to 80 of about 13,799 (198)

LncRNA CYP1B1-AS1 as a clinical biomarker exacerbates sepsis inflammatory response via targeting miR- 18a- 5p

BMC Immunology
Background Sepsis, characterized by high morbidity and mortality, necessitates the identification of novel diagnostic and prognostic biomarkers to enhance patient outcomes.
Lixia Xu, Jingpo Li, Li Li, Qiushuang Zhang, Qiuju Feng, Lijie Bai   +5 more
doaj   +1 more source

Effects of SNPs (CYP1B1*2 G355T, CYP1B1*3 C4326G, and CYP2E1*5 G-1293C), smoking, and drinking on susceptibility to laryngeal cancer among Han Chinese. [PDF]

PLoS ONE, 2014
PURPOSE: This study was conducted to explore the effects of genetic polymorphisms (CYP1B1*2 G355T, CYP1B1*3 C4326G, and CYP2E1*5 G-1293C) and environmental factors (smoking and drinking) on susceptibility to laryngeal cancer in a Han Chinese study group.
Jianhua Jin, Faming Lin, Shiyu Liao, Qiyu Bao, Liyan Ni   +4 more
doaj   +1 more source

Explore the Mechanism of Xiaoyaosan for Treatment of Bipolar Disorder Based on Network Pharmacology, Experimental Validation and Molecular Docking

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
This study evaluates Xiaoyaosan (XYS) for bipolar disorder (BD) using network pharmacology and experimental validation. Molecular docking reveals interactions between active XYS compounds and potential core targets. Animal experiments confirm XYS alleviates BD‐like behaviors in mice by suppressing core targets, elucidating its multi‐target mechanism ...
Man Chen, Nana Ding, Xingmin Qiu, Lan Li, Yali Guo, Rongyanqi Wang, Xiaowei Mo, Tan Zou, Shangzhen Yu, Xiaojuan Li, Jiaxu Chen   +10 more
wiley   +1 more source

Expression and Clinical Significance of Cytochrome 1B1 in Bone Sarcomas

Pharmaceuticals
Background/Objectives: Cytochrome 1B1 (CYP1B1) is overexpressed in several cancers, contributing to carcinogenesis, cancer progression, and chemoresistance. Despite its known oncogenic role, its expression in bone sarcomas remains unknown.
Belal Al-zu’bi, Fatemah OFO Alshammari, Randa AlQaisi, Jaber H. Jaradat, Marwan Herzallah, Mohannad Ja’Awin, Anas O. Satari, Yousef M. Al-saraireh, Mohammad Salem Hareedy   +8 more
doaj   +1 more source

Association of CYP1B1 codon 432 mutant allele in head and neck squamous cell cancer is reflected by somatic mutations of p53 in tumor tissue [PDF]

, 2001
Tobacco use is causally associated with head and neck squamous cell cancer (HNSCC). Here, we present the results of a case-control study that investigated the effects that the genetic variants of the cytochrome (CYP)1A1, CYP1B1, glutathione-S-transferase
Sachinidis, A, Vetter, H, Harth, Volker, Thier, R, Vetter, Hans, Fischer, HP, Herberhold, C, Bolt, HM, Ortiz-Pallardo, Maria Elena, Brüning, Thomas, Abel, Josef, Fischer, Hans-Peter, Ko, Yon, Antony, Christiane, Bröde, Peter, Abel, J, Bolt, Hermann-Maximilian, Thier, Ricarda, Herberhold, Claus, Ortiz-Pallardo, ME, Donat, S, Bruning, T, Brode, P, Ko, Y, Antony, C, Harth, V, Sachinidis, Agapios, Donat, Susanne   +27 more
core  

11-Hydroxyeicosatetraenoics induces cellular hypertrophy in an enantioselective manner

Frontiers in Pharmacology
BackgroundR/S enantiomers of 11-hydroxyeicosatertraenoic acid (11-HETE) are formed from arachidonic acid by enzymatic and non-enzymatic pathways. 11-HETE is predominately formed by the cytochrome P450 1B1 (CYP1B1).
Sara A. Helal, Sara A. Helal, Ahmed A. El-Sherbeni, Ayman O. S. El-Kadi   +3 more
doaj   +1 more source

Screening of West Siberian patients with primary congenital glaucoma for CYP1B1 gene mutations

Вавиловский журнал генетики и селекции, 2020
Primary congenital glaucoma (PСG) is a visual organ pathology that leads to progressive blindness and poor vision in children. Its main cause is an anomaly of the anterior chamber angle.
D. E. Ivanoshchuk, S. V. Mikhailova, O. G. Fenkova, E. V. Shakhtshneider, A. Z. Fursova, I. V. Bychkov, M. I. Voevoda   +6 more
doaj   +1 more source

Association between CYP1A2 and CYP1B1 polymorphisms and colorectal cancer risk: a meta-analysis. [PDF]

PLoS ONE, 2014
BACKGROUND: The previous published data on the association between CYP1A2*F (rs762551), CYP1B1 Leu432Val (rs1056836), Asn453Ser (rs180040), and Arg48Gly (rs10012) polymorphisms and colorectal cancer risk remained controversial.
Xiao-Feng He, Jie Wei, Zhi-Zhong Liu, Jian-Jun Xie, Wei Wang, Ya-Ping Du, Yu Chen, Hui-Qiang Si, Qing Liu, Li-Xia Wu, Wu Wei   +10 more
doaj   +1 more source

Enzyme Activities of CYP1A and CYP1B1 alleles

, 2014
Raw and relative enzyme activities of CYP1A and CYP1B1 ...
Mitani, Hiroshi, Kataoka, Hiroshi, Shigeki Nakagome (484043), Nakagome, Shigeki, Shoji Kawamura (78038), Hiroki Oota (58425), Katsumura, Takafumi, Takafumi Katsumura (841399), Tsunehiko Hanihara (3327600), Shoji Oda (136511), Hiroshi Mitani (24201), Kawamura, Shoji, Oota, Hiroki, Hanihara, Tsunehiko, Oda, Shoji, Hiroshi Kataoka (270804)   +15 more
core   +1 more source

Tobacco smoke induces CYP1B1 in the aerodigestive tract [PDF]

Carcinogenesis, 2004
Several members of the P450 family, including cytochrome P450 1B1 (CYP1B1), can convert tobacco smoke (TS) procarcinogens, including benzo[a]pyrene (B[a]P), to carcinogenic intermediates. In this study we investigated the effects of TS condensate and B[a]P on the expression of CYP1B1 in vitro and in vivo. CYP1B1 mRNA and protein were induced by both TS
Jeffrey L, Port, Kentaro, Yamaguchi, Baoheng, Du, Mariana, De Lorenzo, Mindy, Chang, Paul M, Heerdt, Levy, Kopelovich, Craig B, Marcus, Nasser K, Altorki, Kotha, Subbaramaiah, Andrew J, Dannenberg   +10 more
openaire   +2 more sources