Results 91 to 100 of about 13,799 (198)
Cell Proliferation, Volume 59, Issue 10, October 2026.During development, the oxygen‐sensitive transcription factor Zeb2 restrains astrocyte proliferation and maturation to ensure balanced retinal angiogenesis. In disease, it promotes the neurotoxic A1 astrocyte phenotype and inflammation, thereby promoting reparative revascularization over pathological neovascularization.
Jing Liu +5 more
wiley +1 more source
CYP1B1 mutants cause upregulation of MYOC in HTM cells.
, 2012 A: Increased MYOC expression with mutant CYP1B1. Western blot analysis of mutant CYP1B1 and myocilin showed increased expression of MYOC in the presence of mutant CYP1B1 clones with reduced (
Moulinath Acharya (47511) +4 more
core +1 more source
CYP1B1*4 influences 8-MOP metabolism.
, 2013 aIC50 for 8-MOP against CYP1B1-dependent EROD activity determined using E. coli membranes co-expressing human individual CYP1B1 alleles and CPR as described in Materials and Methods. Data represents the mean ± SD of triplicate determinations.
C. Roland Wolf (293805) +4 more
core +1 more source
Neoplasia: An International Journal for Oncology ResearchClear cell renal cell carcinoma (ccRCC) is strongly aetiologically associated with von Hippel‒Lindau (VHL) tumour suppressor gene mutations, which result in constitutive activation of hypoxia-inducible factors and pathological angiogenesis.
Ke Ma +9 more
doaj +1 more source
, 2010 Studies investigating possible associations between cytochrome P4501B1 (CYP1B1) polymorphisms and breast cancer risk have been inconsistent. We set out to ascertain whether there might be an association between polymorphisms in exon 2 (codon 119, G→T ...
Chunlian Liu +5 more
core
Expression of cytochrome P450 CYP1B1 in breast cancer
FEBS Letters, 1995 The expression of CYP1B1 has been identified in breast cancer using the reverse transcriptase‐polymerase chain reaction and immunoblotting. CYP1B1 mRNA was expressed in the majority of breast tumours and immunoblotting of breast tumours identified a single protein band of molecular weight 60 kDa corresponding to the predicted molecular weight of human ...
McKay, Judith A. +7 more
openaire +2 more sources
Mutations of the CYP1B1 gene in congenital anterior staphylomas
Clinical Ophthalmology, 2014 Here, we present two patients with congenital anterior staphyloma, with mutations in the CYP1B1 gene.We reviewed the medical records, including the genetic analysis.Two unrelated patients presented with congenital anterior staphylomas. Both patients showed mutations in the CYP1B1 gene. The first patient, the product of a consanguineous marriage, showed
Al Judaibi R +4 more
openaire +4 more sources
Dexfenfluramine and the oestrogen-metabolizing enzyme CYP1B1 in the development of pulmonary arterial hypertension [PDF]
, 2013 <p>Aims: Pulmonary arterial hypertension (PAH) occurs more frequently in women than men. Oestrogen and the oestrogen-metabolising enzyme cytochrome P450 1B1 (CYP1B1) play a role in the development of PAH.
White, K. +17 more
core +1 more source
Scheme for the novel mechanisms of CYP1B1 action.
, 2016 Scheme for CYP1B1-induced cell proliferation via activation of Wnt/β-catenin signaling and CYP1B1-induced celll migration and invasion through induction of EMT.
Hyoung-Seok Baek (3178263) +5 more
core +1 more source
, 1999 CYP1B1-null mice, created by targeted gene disruption in embryonic stem cells, were born at the expected frequency from heterozygous matings with no observable phenotype, thus establishing that CYP1B1 is not required for mouse development. CYP1B1 was not
Buters, JT;Sakai, S;Richter, T;Pineau, T;Alexander, DL;Savas, U;Doehmer, J;Ward, JM;Jefcoate, CR;Gonzalez, FJ
core +1 more source