Results 51 to 60 of about 13,799 (198)

Gut Microbiota‐Derived Indole‐3‐Acetaldehyde Contributes to the Disease‐Alleviating Effects of Kurarinone in Experimental Autoimmune Encephalomyelitis

Advanced Science, EarlyView.
Kurarinone ameliorates EAE via the gut microbiota‐indole‐3‐acetaldehyde‐AhR axis. Kurarinone reshapes gut microbiota and increases Akkermansia muciniphila, which promotes intestinal indole‐3‐acetaldehyde production. Indole‐3‐acetaldehyde crosses the intestinal barrier, activates AhR in CD4+ T cells, upregulates SOCS1/3, inhibits JAK2 and STAT3/4 ...
Xinyan Han, Jiaqi Ding, Zonghao Pan, Weitai He, Xue Kang, Cong Zhao, Yi Li, Di Wu, Hongzeng Li, Kaixi Ren, Jiaji Lin, Jun Guo   +11 more
wiley   +1 more source

Expression profiling of CYP1B1 in oral squamous cell carcinoma: counterintuitive downregulation in tumors. [PDF]

PLoS ONE, 2011
Oral Squamous Cell Carcinoma (OSCC) has a very flagitious treatment regime. A prodrug approach is thought to aid in targeting chemotherapy. CYP1B1, a member of cytochrome P450 family, has been implicated in chemical carcinogenesis. There exists a general
Shalmali Pradhan, M N Nagashri, K S Gopinath, Arun Kumar   +3 more
doaj   +1 more source

Adenosine—A Regulator of Human Testicular Peritubular Cells

Andrology, EarlyView.
ABSTRACT Background Extracellular purines, in particular ATP and adenosine, are regulators of physiological and pathophysiological processes throughout the human body. Roles in the human testis are emerging and include actions on peritubular cells, which form the wall of seminiferous tubules.
Lina Scholz, Annika Liebich, Youli Stepanov, Jan B. Stöckl, Mirko Peitzsch, Michaela Schneider, Julia Schneider, Nicole Kreitmair, Matthias Trottmann, Frank‐Michael Köhn, Jovica Ninkovic, Thomas Fröhlich, Artur Mayerhofer   +12 more
wiley   +1 more source

Trans‐resveratrol alleviates inflammation and improves skin barrier function via aryl hydrocarbon receptor pathway in human reconstructed epidermis

International Journal of Cosmetic Science, EarlyView.
In a cytokine‐challenged human epidermal model, trans‐resveratrol reduces inflammation (IL‐1α) and oxidative stress markers (CYP1A1, CYP1B1), while modulating the expression of barrier‐related genes (LOR, OCLN) and differentiation‐associated CASP14. This supports its role as a multifunctional active for sensitive and compromised skin.
Irini M. Dijkhoff, Sandeep Keshavan, Regina G. Daré, Alke Petri‐Fink, Marc Eeman, Agnès Tessier, Barbara Rothen‐Rutishauser   +6 more
wiley   +1 more source

The importance of CYP1B1 polymorphism in obesity

Medicine
Obesity is a multifactorial disease, commonly observed both worldwide and in our country, triggered by environmental and genetic factors, adversely affecting all physiological functions of the body, and leading to an increase in body fat mass.
Murat Cilekar, Fatma Ozlem Kargin Solmaz, Nilay Isite   +2 more
openaire   +2 more sources

Cyp1b1 directs Srebp-mediated cholesterol and retinoid synthesis in perinatal liver; Association with retinoic acid activity during fetal development.

PLoS ONE, 2020
BackgroundCytochrome P450 1b1 (Cyp1b1) deletion and dietary retinol deficiency during pregnancy (GVAD) affect perinatal liver functions regulated by Srebp.
Meghan Maguire, Michele Campaigne Larsen, Chad M Vezina, Loredana Quadro, Youn-Kyung Kim, Sherry A Tanumihardjo, Colin R Jefcoate   +6 more
doaj   +1 more source

Expression profile of CYP1A1 and CYP1B1 enzymes in colon and bladder tumors. [PDF]

PLoS ONE, 2013
BACKGROUND: The cytochrome P450 CYP1A1 and CYP1B1 enzymes are involved in carcinogenesis via activation of pro-carcinogenic compounds to carcinogenic metabolites.
Vasilis P Androutsopoulos, Ioannis Spyrou, Achilles Ploumidis, Alexandros Eystathios Papalampros, Michalis Kyriakakis, Demetrios Delakas, Demetrios A Spandidos, Aristidis M Tsatsakis   +7 more
doaj   +1 more source

Epigenetic Regulation in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
The aim of this narrative literature review was to identify epigenetic marks associated with periodontitis and to place them in a biological context. The literature was reviewed based on pre‐defined criteria. Cell type specific chromatin and mRNA modifications were included.
Henrik Dommisch, Arne Sönke Schäfer, Denica Kuzmanova, Dominique S. Michaud   +3 more
wiley   +1 more source

CYP1B1 Knockout in a Bovine Hepatocyte-like Cell Line (BFH12) Unveils Its Role in Liver Homeostasis and Aflatoxin B1-Induced Hepatotoxicity

Toxins
CYP1B1 is a key enzyme involved in xenobiotic and endogenous metabolism, yet its physiological role in bovine liver homeostasis remains unclear. In this study, we generated a CYP1B1 knockout (CYP1B1KO) bovine hepatocyte-like cell line to indirectly ...
Silvia Iori, Ludovica Montanucci, Caterina D’Onofrio, Maija Lahtela-Kakkonen, Lorena Lucatello, Anisa Bardhi, Andrea Barbarossa, Francesca Capolongo, Anna Zaghini, Marianna Pauletto, Mauro Dacasto, Mery Giantin   +11 more
doaj   +1 more source

TNFSF14/LIGHT responses in intestinal and oesophageal fibroblasts are differentially modulated by hydroxylase inhibitors

The Journal of Physiology, EarlyView.
Abstract figure legend LIGHT is a mutual mediator of intestinal and oesophageal fibroblast inflammation with common as well as tissue‐specific effects. Hydroxylase inhibitors can selectively suppress inflammatory factors in both cell types, albeit targeting different signalling pathways.
Cian M. Ohlendieck, Carlos Matellan, Cristina Bauset, Bella Raphael, Mary Nwaezeigwe, Emer Flynn, Kevin Okamoto, Desmond Winter, Colm Collins, Katie Doogan, Seán T. Martin, Glen Doherty, Seema S. Aceves, Mario C. Manresa   +13 more
wiley   +1 more source