Results 11 to 20 of about 13,799 (198)

Investigation of CYP1B1*3 and CYP1B1*4 polymorphisms in a Turkish population [PDF]

HEALTH SCIENCES QUARTERLY, 2022
CYP1B1 is a P450 enzyme involved in activating pro-carcinogens to carcinogens as well as estrogen metabolism. In order to examine the effect of CYP1B1 on cancer metabolism, it should be compared with healthy individuals and whether the polymorphism ...
Solmaz Kargın, Fatma Özlem, Ada, Ahmet Oğuz, Merve Becit Kızılkaya, Becit Kızılkaya, Merve, Ahmet Oğuz Ada, Fatma Özlem Solmaz Kargın, Kargın Solmaz, Fatma Özlem, Jale Akgöl, Akgöl, Jale   +8 more
core   +3 more sources

CYP1B1 Detection

Current Protocols in Toxicology, 2012
This unit describes procedures for measuring CYP1B1 gene expression by reverse transcription real-time PCR (qRT-PCR), CYP1B1 protein levels by western blotting, and CYP1B1 enzyme activity through conversion of 7-ethoxyresorufin substrate.
Mukesh Verma, Brinda Mahadevan, Andreas Luch, Rao L. Divi, Divi,R.L., Luch,A., Verma,M., Mahadevan,B.   +7 more
core   +3 more sources

Proteasomal degradation of human CYP1B1: effect of the Asn453Ser polymorphism on the post-translational regulation of CYP1B1 expression

Molecular Pharmacology, 2005
Allelic variations in CYP1B1 are reported modulate the incidence of several types of cancer. To provide a mechanistic basis for this association, we investigated the impact of nonsilent allelic changes on the intracellular levels and post-translational ...
Bandiera, Silvio, Friedberg, Thomas, Ko, Yun, Harth, Volker, Weidlich, Simone, Broede, Peter   +5 more
core   +4 more sources

Specificity Determinants of CYP1B1 Estradiol Hydroxylation [PDF]

Molecular Pharmacology, 2013
Cytochrome P450 (P450)-catalyzed oxidation of the aromatic ring of estradiol can result in 2- or 4-hydroxylation. Which of these products is formed is biologically important, as the 4-hydroxylated metabolite is carcinogenic, whereas the 2-hydrox-ylated ...
Nishida, Clinton R, Clinton R Nishida, Clinton R. Nishida, Paul R. Ortiz De Montellano, Everett, Steven, de Montellano, Paul R Ortiz, Paul R Ortiz De Montellano, Steven Everett   +7 more
core   +6 more sources

Insights into CYP1B1-Related Ocular Diseases Through Genetics and Animal Studies

Life
The CYP1B1 gene encodes a cytochrome p450 monooxygenase enzyme, and over 150 variants have been associated with a spectrum of eye diseases, including primary congenital glaucoma, anterior segment dysgenesis, juvenile open-angle glaucoma, and primary open-
Elizabeth M. Bolton, Andy Drackley, Antionette L. Williams, Brenda L. Bohnsack   +3 more
doaj   +2 more sources

Analysis of CYP1B1 sequence alterations in patients with primary open-angle glaucoma of Saudi origin

Clinical Ophthalmology, 2018
Khaled K Abu-Amero, Tahira Sultan, Saleh A Al-Obeidan, Altaf A Kondkar Glaucoma Research Chair, Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia Abstract: Cytochrome P450 Family 1 Subfamily B Member 1 (CYP1B1;
Abu-Amero KK, Sultan T, Al-Obeidan SA, Kondkar AA   +3 more
doaj   +1 more source

CYP1B1-AS1 regulates CYP1B1 to promote Coxiella burnetii pathogenesis by inhibiting ROS and host cell death

Nature Communications
Coxiella burnetii (Cb), the causative agent of Q fever, replicates within host macrophages by modulating immune responses through poorly understood mechanisms.
Aryashree Arunima, Seyednami Niyakan, Samantha M. Butler, Sabrina D. Clark, Anna Pinson, Doyoung Kwak, Elizabeth Di Russo Case, Xiaoning Qian, Paul de Figueiredo, Erin J. van Schaik, James E. Samuel   +10 more
doaj   +5 more sources

Cytochrome P450 CYP1B1 in breast cancer. [PDF]

, 1998
This poster gives an overview of recent research into cytochrome P450 CYP1B1, which has previously been shown to present increased expression in several types of human cancer.
Miller, I.D., Payne, S., McFadyen, M.C.E., Melvin, W.T., Murray, G.I., Buchan, S.   +5 more
core   +6 more sources

Cyp1b1 expression impacts the angiogenic and inflammatory properties of liver sinusoidal endothelial cells. [PDF]

PLoS ONE, 2018
Cytochrome P450 1B1 (CYP1B1) is a member of the cytochrome p450 family of enzymes that catalyze mono-oxygenase reactions. Although constitutive Cyp1b1 expression is limited in hepatocytes, its expression and function in liver sinusoidal endothelial cells
Juliana Falero-Perez, Yong-Seok Song, Yun Zhao, Leandro Teixeira, Christine M Sorenson, Nader Sheibani   +5 more
doaj   +1 more source

Carrier Status for p.Gly61Glu and p.Arg368His CYP1B1 Mutations Causing Primary Congenital Glaucoma in Iran

Journal of Ophthalmic & Vision Research, 2021
Purpose: To estimate carrier frequencies of CYP1B1 mutations p.Gly61Glu and p.Arg368His, respectively, in Talesh and the east of Guilan province in Iran with a maximum error of 2%.
Ali Heshmati, Peyman Taghizadeh, Hamid Ahmadieh, Mehdi Yaseri, Fatemeh Suri, Mahsa Alizadeh, Marjan Dadashzadeh, Hajar Khatami, Monireh Moradkhah Navi, Parisa Zamanparvar, Hassan Behboudi, Elahe Elahi   +11 more
doaj   +1 more source