Results 111 to 120 of about 34,953 (257)

Impact of Cyp1A1 and Comt Genotypes on Breast Cancer Risk in Mexican Women: A Pilot Study

The International Journal of Biological Markers, 2010
Background Data suggest that estrogen-metabolizing genes may be involved in breast cancer carcinogenesis. Objective The aim of this study was to determine the association of CYP1A1 and COMT polymorphisms with this disease.
Mónica Moreno-Galván, Norma Estela Herrera-González, Vera Robles-Pérez, Julio C. Velasco-Rodríguez, Roberto Tapia-Conyer, Elsa Sarti PhD   +5 more
doaj   +1 more source

Mechanistic Insights Into How Acupuncture Modulates Host Immunity via the Gut Microbiota‐Macrophage Axis

Immunity, Inflammation and Disease, Volume 14, Issue 11, November 2026.
Electroacupuncture at specific acupoints (e.g., ST36, ST25) activates somato‑vagal neural circuits via PROKR2‑expressing sensory fibers. This top‑down signal restructures the gut microenvironment by enriching beneficial symbionts (e.g., Akkermansia muciniphila) and strengthening the intestinal barrier.
Tao Yang, Mei Li, Xiaowen Wu
wiley   +1 more source

High Frequency of CYP1A1*2C Allele in Brazilian Populations

, 2011
The genetic variability of the CYP1A1 I462V polymorphism (CYP1A1*2C) was investigated in four Brazilian populations: three groups of African descent and one group of European descent.
Hutz, Mara H., Papadópolis, Lidia G., Kvitko, Katia, Gaspar, Pedro A., Weimer, Tania A.   +4 more
core   +1 more source

Expression Profile of CYP1A1 and CYP1B1 Enzymes in Colon and Bladder Tumors

PLoS ONE, 2013
Background The cytochrome P450 CYP1A1 and CYP1B1 enzymes are involved in carcinogenesis via activation of pro-carcinogenic compounds to carcinogenic metabolites.
V. Androutsopoulos, Ioannis Spyrou, A. Ploumidis, A. Papalampros, Michalis Kyriakakis, D. Delakas, D. Spandidos, A. Tsatsakis   +7 more
semanticscholar   +1 more source

Polymorphism of the CYP1A1*2A gene and susceptibility to lung cancer in a Brazilian population O polimorfismo do gene CYP1A1*2A e a suscetibilidade ao câncer de pulmão na população brasileira

Jornal Brasileiro de Pneumologia, 2009
OBJECTIVE: To estimate and compare the frequency of CYP1A1*2A gene polymorphisms in a Brazilian population and determine the possible contribution of these genetic variations to lung cancer risk.
Helen Naemi Honma, Eduardo Mello De Capitani, Aristóteles de Souza Barbeiro, Daniel Botelho Costa, André Morcillo, Lair Zambon   +5 more
doaj   +1 more source

Pelargonidin activates the AhR and induces CYP1A1 in primary human hepatocytes and human cancer cell lines HepG2 and LS174T

Toxicology Letters, 2013
We examined the effects of anthocyanidins (cyanidin, delphinidin, malvidin, peonidin, petunidin, pelargonidin) on the aryl hydrocarbon receptor (AhR) – CYP1A1 signaling pathway in human hepatocytes, hepatic HepG2 and intestinal LS174T cancer cells.
Alzbeta Kamenickova, E. Anzenbacherová, P. Pávek, A. Soshilov, M. Denison, P. Anzenbacher, Z. Dvořák   +6 more
semanticscholar   +1 more source

Iodized Garlic Extract Regulates Stress Responses in Epidermal Keratinocytes via the Transcription Factor Nrf2

Journal of Cosmetic Dermatology, Volume 25, Issue 11, November 2026.
ABSTRACT Objective Garlic exerts protective effects against skin stress, including oxidative damage and trauma. Iodized garlic extract (IGEx) is a cosmetic ingredient developed through iodination of garlic odor components to achieve odor reduction. Although IGEx is expected to exhibit skin stress protection properties similar to garlic, the molecular ...
Yuki Miyauchi, Natsumi Iwasaki, Liangjing Xie, Satoshi Yano, Taichi Hara   +4 more
wiley   +1 more source

Novel Nonsynonymous Polymorphisms of the CYP1A1 Gene in Japanese

Drug Metabolism and Pharmacokinetics, 2003
We found five novel nonsynonymous polymorphisms of the human CYP1A1 gene from Japanese individuals. The five single nucleotide polymorphisms (SNP) in exon 7 (2346_2347 ins T, 2414T>A, 2461C>T, 2500C>T and 2546C>G causing premature stop codon, Ile(448)Asn, Arg(464)Cys, and Arg(477)Trp and Pro(492)Arg, respectively) were as follows:SNP, 030212Saito001 ...
SAITO, Tetsuya, EGASHIRA, Mari, KIYOTANI, Kazuma, FUJIEDA, Masaki, YAMAZAKI, Hiroshi, KIYOHARA, Chikako, KUNITOH, Hideo, KAMATAKI, Tetsuya   +7 more
openaire   +2 more sources

Epigenetic modifications control CYP1A1 Inducibility in human and rat keratinocytes [PDF]

Serially passaged rat keratinocytes exhibit dramatically attenuated induction of Cyp1a1 by aryl hydrocarbon receptor ligands such as TCDD. However, the sensitivity to induction can be restored by protein synthesis inhibition.
Rice, Robert H, Ehrlich, Allison K, Lin, Lo-Wei   +2 more
core   +1 more source

Riluzole‐Derived Benzo[d]thiazoles as CK1δ Inhibitors for Amyotrophic Lateral Sclerosis‐Related Neurodegeneration

ChemMedChem, Volume 21, Issue 20, 28 October 2026.
Riluzole metabolism guided the design of benzo[d]thiazole inhibitors of casein kinase 1 delta (CK1δ), a kinase linked to amyotrophic lateral sclerosis (ALS). Docking supported ATP site recognition by the hydroxylamine metabolite and hydrazine analogues, leading to compounds showing improved potency and retained predicted blood brain barrier ...
Simone Adorinni, Ilenia Grieco, Stefano Morasso, Michelle Fornasier, Gianluca Novello, Veronica Salmaso, Loreto Martínez‐González, Eleonora Cescon, Davide Bassani, Giovanni Adriano Bassan, Teresa Gianferrara, Filippo Prencipe, Veronika Kost, Tatiana Da Ros, Paola Storici, Ana Martinez, Giampiero Spalluto, Stefano Moro, Stephanie Federico   +18 more
wiley   +1 more source