Results 131 to 140 of about 34,953 (257)
A Modeling Investigation of the CYP1A Drug Interactions of Riluzole
Clinical and Translational ScienceCytochrome‐P‐450 (CYP)1A2 has been considered the major enzyme metabolizing riluzole since its approval. However, the inhibitor that was used in the original experiments, α‐naphthoflavone, is also a potent inhibitor of CYP1A1.
Paul Malik +4 more
doaj +1 more source
Chinese Journal of Lung Cancer, 2011 Background and objective Cytochrome P450A1 (CYP1A1) gene and glutathione S-transferase M1 (GSTM1) gene both have single nucleotide polymorphisms and effects on lung cancer. Currently, however, the risk of lung cancer due to the CYP1A1 and GSTM1 genes has
Cheng LI, Zhihua YIN, Baosen ZHOU
doaj +1 more source
, 2005 In adult mice the cytochrome P450 Cyp1a1 gene is not constitutively expressed but is highly inducible by foreign compounds acting through the aryl hydrocarbon (Ah) receptor.
Davidson, Duncan +5 more
core +1 more source
Journal of Orthopaedic TranslationBackground/objective: Bone homeostasis, maintained by a balance between osteoblastic bone formation and osteoclastic bone resorption, is disrupted in osteoporosis, leading to reduced bone mass and increased fracture risk.
Yining Liu +6 more
doaj +1 more source
DETERMINING IF BURNT FOOD CAN INDUCE CYP1A1 EXPRESSION IN MOUSE HEPATOCYTES**
, 2021 Benzo[a]pyrene (B[a]P) is a polycyclic aromatic hydrocarbon found in cigarette smoke and burnt meats. B[a]P is a ligand of the aryl hydrocarbon receptor, which binds to the promoter region of the cyp1a1 gene, causing expression of the CYP1A1 enzyme ...
Hiller, Carley E. +1 more
core
The Association of CYP1A1 rs1048943 Polymorphism
The International Journal of Comprehensive Health, Medicine, & DentistryBreast cancer remains the most prevalent malignancy in women worldwide and its etiology involves genetic and environmental components. Among these genetic components, the CYP1A1 rs1048943 (Ile462Val) polymorphism has been shown to play a modifying role in breast cancer susceptibility based on its contribution to the metabolism of carcinogens and ...
openaire +1 more source
CYP1A1 enzymatic activity influences skin inflammation via regulation of the AHR pathway.
, 2021 The Aryl hydrocarbon Receptor (AHR) is an environmental sensor and transcription factor activated by a variety of man-made and natural ligands, which has recently emerged as critical regulator of homeostasis at barrier organs such as the skin. Activation
Jonathan Hardman-Smart (10877817) +13 more
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Discover OncologyObjective Fulvic acid (FA), a humic substance, has various applications in agricultural (animal husbandry) and pharmaceutical industries. However, to the best of our knowledge, its antitumor effects remain unclear.
Min Chen +5 more
doaj +1 more source
CYP1A1 Gene: A Cancer Risk Modifier [PDF]
, 2011 CYP1A1gene is an important target in cancer, due to its role in metabolic bioactivation of polycyclic aromatic hydrocarbons (PAHs),to electrophilic intermediates referred to bay region epoxides, to ultimate carcinogens and capable of causing oncogenic ...
เริ่มรักสกุล, ปภิมล +3 more
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