Results 141 to 150 of about 15,644 (193)

N-nitrosodimethylamine induces cytochrome P450 activation but not epithelial remodeling in well-differentiated human airway epithelial cells. [PDF]

Cell Biol Toxicol
Khan F, Solan ME, Kim HJ, Wright C, Park JA.   +4 more
europepmc   +1 more source

New insights on the role of some biometals in mancozeb induced hematological and hepatorenal toxicity in rats and the protective effect of naringin. [PDF]

Biometals
Elbagwry SS, Hassanen EI, Azouz RA, Ibrahim MA, Doghaim R.   +4 more
europepmc   +1 more source

E-cigarette exposure impairs skeletal muscle mitochondrial function in male mice. [PDF]

Physiol Rep
Mazirka P, Choi J, Alvarez S, Jahuey P, O'Malley KA, Robinson ST, Scali ST, Ryan TE, Berceli SA, Kim K.   +9 more
europepmc   +1 more source

Indole-3-aldehyde Preserves Gingival Epithelial Barrier Structure and Function Via AhR/Nrf2 Signaling Pathway. [PDF]

Inflammation
Wu L, Wu S, Deng Y, Li J, Zhang C, Wang Y, Zhao C, Gao L.   +7 more
europepmc   +1 more source

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CYP1A1*2 and CYP1A1*3 Polymorphisms cosegregate in the Indian Population

Anthropologischer Anzeiger, 2002
Several ethnic groups have been genotyped for polymorphisms at the CYP1A1 gene locus that encodes the enzyme that catalyzes the initial step in the metabolism of polycyclic aromatic hydrocarbons. Two of the CYP1A1 polymorphisms, namely, CYP1A1*2 and CYP1A1*3 are reported to cosegregate among the Japanese and to a lesser extent in Caucasians, but not in
Aparna, Kotekar, Rajani, Bhisey
openaire   +2 more sources

Human CYP1A1 inhibition by flavonoids

Toxicology in Vitro, 2020
Cytochrome P4501A1 (CYP1A1) is involved in the metabolism of several genotoxic/carcinogenic environmental xenobiotics including polycyclic aromatic hydrocarbons (PAHs) like benzo[a]pyrene. Several authors had proposed CYP1A inhibition as a plausible strategy for cancer chemoprevention.
Rebeca, Santes-Palacios, Ana L, Marroquín-Pérez, Sandra L, Hernández-Ojeda, Rafael, Camacho-Carranza, Tzipe, Govezensky, J Javier, Espinosa-Aguirre   +5 more
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Dietary Ellagic Acid Inhibits the Enzymatic Activity of CYP1A1 without Altering Hepatic Concentrations of CYP1A1 or CYP1A1 mRNA

Biochemical and Biophysical Research Communications, 1994
The anticarcinogen ellagic acid significantly reduces the incidence of polycyclic aromatic hydrocarbon induced carcinomas, in association with significant reductions in benzo[a]pyrene hydroxylase activity and CO reducible hepatic cytochrome P450. This suggested that ellagic acid reduced hepatic concentrations of CYP1A1, but these changes occurred ...
D H, Barch, L M, Rundhaugen, P E, Thomas, P, Kardos, N S, Pillay   +4 more
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CYP1A1, smoking and venous thromboembolism

Thrombosis and Haemostasis, 2010
SummarySince CYP1A1 enzyme is involved in metabolism of tobacco carcinogens, the CYP1A1 gene may be of relevance to smoking-induced differences in the risks of venous thromboembolism (VTE). We conducted a case-control study to investigate genetic polymorphisms in CYP1A1 that might modify the risk of developing VTE.
Jin, Zhu, Wen-Jie, Zheng, Fan-Cui, Kong, Wei-Juan, Zhang, He-Yao, Wang, Chen, Wang   +5 more
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The CYP1A1 gene and cancer susceptibility

Critical Reviews in Oncology/Hematology, 1993
A close correlation between cigarette smoking associated lung cancer incidence and an Msp I restriction fragment length polymorphism (RFLP) of the human P-450 1A1 (CYP1A1) gene was found in a Japanese population in terms of genotype frequency and cigarette dose.
K, Kawajiri, K, Nakachi, K, Imai, J, Watanabe, S, Hayashi   +4 more
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Regulation of CYP1A1 expression

The FASEB Journal, 1992
CYP1A1 is considered to be involved mainly in oxidative metabolism of exogenous chemicals and drugs. Synthesis of this hemoprotein is induced in livers, lungs, and other tissues of experimental animals by the administration of these chemicals.
Y, Fujii-Kuriyama, H, Imataka, K, Sogawa, K, Yasumoto, Y, Kikuchi   +4 more
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