Cytochrome P450 1A1 is essential for the microbial metabolite, Urolithin A-mediated protection against colitis [PDF]
Frontiers in Immunology, 2022 BackgroundCytochrome P450 Family 1 Subfamily A Member 1 (CYP1A1) pathway, which is regulated by aryl hydrocarbon receptor (AhR) plays an important role in chemical carcinogenesis and xenobiotic metabolism.
Venkatakrishna Jala +2 more
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An electron transfer competent structural ensemble of membrane-bound cytochrome P450 1A1 and cytochrome P450 oxidoreductase [PDF]
Communications Biology, 2021 Mukherjee, Nandekar and Wade investigate the structural arrangement of the complex between membrane-bound cytochrome P450 1A1 and NADPH-cytochrome P450 reductase.
Goutam Mukherjee +2 more
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Cytochrome P450 1A1 enhances inflammatory responses and impedes phagocytosis of bacteria in macrophages during sepsis [PDF]
Cell Communication and Signaling, 2020 The hydroxylase cytochrome P450 1A1 (CYP1A1) is regulated by the inflammation-limiting aryl hydrocarbon receptor (AhR), but CYP1A1 immune functions remain unclear.
Li-Xing Tian +11 more
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Knockout of cytochrome P450 1A1 enhances lipopolysaccharide‐induced acute lung injury in mice by targeting NF‐κB activation [PDF]
FEBS Open Bio, 2020 Acute lung injury (ALI) is accompanied by overactivation of multiple pro‐inflammatory factors. Cytochrome P450 1A1 (CYP1A1) has been shown to aggravate lung injury in response to hyperoxia. However, the relationship between CYP1A1 and lipopolysaccharide (
Li‐xing Tian +8 more
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Correction to: Cytochrome P450 1A1 enhances inflammatory responses and impedes phagocytosis of bacteria in macrophages during sepsis [PDF]
Cell Communication and Signaling, 2020 An amendment to this paper has been published and can be accessed via the original article.
Li-Xing Tian +11 more
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Combination effect of cytochrome P450 1A1 gene polymorphisms on uterine leiomyoma: A case-control study [PDF]
Biomolecules & Biomedicine, 2016 Uterine leiomyoma (UL) is an estrogen-dependent neoplasm of the uterus, and estrogen metabolizing enzymes affect its progression. This study aimed to evaluate the association between two single-nucleotide polymorphisms of cytochrome P450 1A1 (CYP1A1 ...
Saeedeh Salimi +7 more
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Cytochrome P450 1A1/2, 2B6 and 3A4 HepaRG Cell-Based Biosensors to Monitor Hepatocyte Differentiation, Drug Metabolism and Toxicity [PDF]
Sensors, 2019 Human hepatoma HepaRG cells express most drug metabolizing enzymes and constitute a pertinent in vitro alternative cell system to primary cultures of human hepatocytes in order to determine drug metabolism and evaluate the toxicity of xenobiotics.
Manuel Vlach +10 more
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Phytochemical profiling, antioxidant properties, and anticancer activity of Pourouma cecropiifolia Mart. from the Ecuadorian Amazon [PDF]
npj Science of FoodSome fruits are used as promising anticancer agents due to their antioxidant and antimutagenic properties. This work explores the potential of the fruit of Pourouma cecropiifolia Mart. as a source of compounds with anticancer activity.
Carlos Méndez-Durazno +10 more
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NUST Journal of Natural Sciences, 2021 Cytochrome P450 enzyme family plays significant roles in carcinogenesis and xenobiotic detoxification. CYP1A1 is the P450 family 1 enzyme preferably expressed extrahepatically and participates extensively in monooxygenase activity which can either ...
Rehan Zafar +3 more
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Human Cytochrome P450 1A1 Structure and Utility in Understanding Drug and Xenobiotic Metabolism [PDF]
Journal of Biological Chemistry, 2013 Emily Scott, Grazyna D Szklarz
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