Results 11 to 20 of about 150,542 (166)

Development of a new platform technology for plant Cytochrome P450 fusions [PDF]

, 2012
To date more than 15000 Cytochromes P450 have been identified and named so far, with one third belonging to the plant kingdom. This is a key biochemical resource, providing a wealth of biocatalysts covering a diverse range of chemistries ...
Schückel, Julia
core   +6 more sources

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

Melatonin Activation by Human Cytochrome P450 Enzymes: A Comparison between Different Isozymes

Molecules, 2023
Cytochrome P450 enzymes in the human body play a pivotal role in both the biosynthesis and the degradation of the hormone melatonin. Melatonin plays a key role in circadian rhythms in the body, but its concentration is also linked to mood fluctuations as
Thirakorn Mokkawes, Tamar De Visser, Yuanxin Cao, Sam P. De Visser   +3 more
doaj   +1 more source

Generation of reactive oxygen species by polyenylpyrroles derivatives causes DNA damage leading to G2/M arrest and apoptosis in human oral squamous cell carcinoma cells. [PDF]

PLoS ONE, 2013
Oral squamous cell carcinoma (OSCC) accounts for 5.8% of all malignancies in Taiwan and the incidence of OSCC is on the rise. OSCC is also a common malignancy worldwide and the five-year survival rate remains poor. Therefore, new and effective treatments
Kuo-Feng Hua, Pei-Chun Liao, Zhanxiong Fang, Feng-Ling Yang, Yu-Liang Yang, Yi-Lin Chen, Yi-Chich Chiu, May-Lan Liu, Yulin Lam, Shih-Hsiung Wu   +9 more
doaj   +1 more source

LPS inhibits arginase-1 expression in macrophages by up-regulating activity of cytochrome P450 1A1 epoxidase

陆军军医大学学报, 2023
Objective To explore the regulative effect and mechanism of cytochrome P450 1A1 (CYP1A1) on regulating lipopolysaccharide (LPS)-induced arginase-1 (Arg-1) expression in macrophages. Methods After mouse macrophage-like cell line RAW264.7 (RAW) was treated
TIAN Lixing, ZHU Junyu, WAN Linghui, LIANG Huaping   +3 more
doaj   +1 more source

NADH:Cytochrome b5 Reductase and Cytochrome b5 Can Act as Sole Electron Donors to Human Cytochrome P450 1A1-Mediated Oxidation and DNA Adduct Formation by Benzo[a]pyrene. [PDF]

Chem Res Toxicol, 2016
Benzo[a]pyrene (BaP) is a human carcinogen that covalently binds to DNA after activation by cytochrome P450 (P450). Here, we investigated whether NADH:cytochrome b5 reductase (CBR) in the presence of cytochrome b5 can act as sole electron donor to human ...
Stiborová M, Indra R, Moserová M, Frei E, Schmeiser HH, Kopka K, Phillips DH, Arlt VM.   +7 more
europepmc   +3 more sources

Inhibitory and inductive effects of 4- or 5-methyl-2-mercaptobenzimidazole, thyrotoxic and hepatotoxic rubber antioxidants, on several forms of cytochrome P450 in primary cultured rat and human hepatocytes

Toxicology Reports, 2020
Effects of 4-methyl-2-mercaptobenzimidazole (4-MeMBI) and 5-methyl-2- mercaptobenzimidazole (5-MeMBI) on cytochrome P450 (CYP) activity were examined in primary cultured rat hepatocytes.
Atsuko Miyajima, Yukie Kuroda, Kazue Sakemi-Hoshikawa, Makoto Usami, Katsuyoshi Mitsunaga, Tomohiko Irie, Yasuo Ohno, Momoko Sunouchi   +7 more
doaj   +1 more source

Expression of cord blood cytochrome P450 1A1 gene according to the air pollution level of the maternal residence area [PDF]

Journal of Research in Medical Sciences, 2014
Background: This study aimed to compare the cytochrome P450 1A1 (CYP1A1) gene expression in the cord blood of infants born from mothers living in low- and high-air polluted areas.
Roya Kelishadi, Abotaleb Mohammadi-Berenjegani, Shaghayegh Haghjooy Javanmard, Mohamadreza Modaresi, Parinaz Poursafa, Marjan Mansourian   +5 more
doaj   +1 more source

Lycopene alleviates aflatoxin B1 induced liver damage through inhibiting cytochrome 450 isozymes and improving detoxification and antioxidant systems in broiler chickens

Italian Journal of Animal Science, 2022
The effects of lycopene on liver damage in Aflatoxin B1 (AFB1)-challenged broilers were investigated. A total of 240 Arbour Acres Broilers in five groups were fed basal diet (control), basal diet with 100 μg/kg AFB1 (AFB1), AFB1 diet with 100, 200, and ...
Xiaoli Wan, Haoran Ji, Huimin Ma, Zhengfeng Yang, Ning Li, Xiaoshuai Chen, Yuanjing Chen, Haiming Yang, Zhiyue Wang   +8 more
doaj   +1 more source

Endocrine-disrupting metabolic activation of 2-nitrofluorene catalyzed by human cytochrome P450 1A1: A QM/MM approach

Environment International, 2022
Nitropolycyclic aromatic hydrocarbons (NPAHs) present one of the most important airborne pollutants. Recent studies have shown that one of the most abundant NPAHs, 2-Nitrofluorene (NF), was supposed to be converted to endocrine-disrupting metabolites by ...
Junhua Zhou, Xin Zhang, Yanwei Li, Shanshan Feng, Qingzhu Zhang, Wenxing Wang   +5 more
doaj   +1 more source